THE RATIONALE BEHIND WEAKLY TIED NETWORKING OF THE BANGLADESHI DIASPORA IN MALAYSIA

This paper is an exploration of the survival strategies of the Bangladeshi Diaspora in Malaysia. To cope with the realities, Bangladeshi migrants develop different forms of survival strategies. As a result intra and inter-ethnic strong and weak ties are formed in the receiving country. Empirical analysis depicts that respondents with weak ties have higher income mobility than those with strong ties. It also demonstrates that the Bangladeshi migrants of the study areas do not restrict themselves only to their close social networks; rather they develop distant networks for higher social mobility. Or in other words, though the ideal socio-cultural model emphasizes community cohesion (something that can be conceptualized as an example of a tightly structured social system), the actual behavior of the Bangladeshi migrants indicates a loosely or disintegrated social system. Migrant's embeddedness in the ongoing social relations and power structures regulates the nature and strength of these ties

Three new records of mysids (Crustacea: Mysidacea) from the northern Arabian Sea

This paper with the systematic study of three species of mysids, collected by R/V "Dr. Fridtjof Nansen", which are new to the northern Arabian Sea. The three species described and illustrated are: Siriella affinis Hansen, Afromysis macropsis Tattersal and Acanthomysis quadrispinosa Nouvel

Emergency management of stroke in the era of mechanical thrombectomy

Emergency management of stroke has been directed at the delivery of recombinant tissue plasminogen activator (tPA) in a timely fashion. Because of the many limitations attached to the delivery of tPA and the perceived benefits accrued to tPA, its use has been limited. Mechanical thrombectomy, a far superior therapy for the largest and most disabling strokes, large vessel occlusions (LVOs), has changed the way acute strokes are managed. Aside from the rush to deliver tPA, there is now a need to identify LVO and refer those patients with LVO to physicians and facilities capable of delivering urgent thrombectomy. Other parts of emergency department management of stroke are directed at identifying and mitigating risk factors for future strokes and at preventing further damage from occurring. We review here the most recent literature supporting these advances in stroke care and present a framework for understanding the role that emergency physicians play in acute stroke care

Production and quality assessment of fish pickles from mola (Amblypharyngodon mola) fish

Fish pickles (with olive and tamarind) were prepared from mola fish (Amblypharyngodon mola) and their nutritional and food quality were assessed. The quality of the pickle prepared with olive was excellent and the pickle prepared with tamarind was found good. Moisture content of the two pickle products were 43.85% (with tamarind) and 50.89% (with olive). The protein and lipid contents of tamarind added pickle were 19.13 and 35.64% respectively; pickle with olive contained less protein (13.16%) compared to tamarind added mola pickle. Lipid contents were almost same in both cases. Ash content of two pickles was also found similar (1.00%). The quality of mola pickles stored either in cool condition (4°C) with vinegar or at room temperature with Na-benzoate were found good for consumption up to 90 days of storage. All of the fish pickles preserved under different condition were found in acceptable condition up to 240 days storage and pickle with vinegar stored at 4°C was found good for consumption at the end of 240 days

Impact of the COVID-19 Pandemic on Learning: Assessing Cognitive, Affective, and Psychomotor Skills

The acquisition of cognitive, affective, and psychomotor skills is highly important for successful learning outcomes. This article aims to evaluate the Three-Domain Model (TDM) of learning (cognitive, affective, and psychomotor) during the COVID-19 online classes for tertiary students in Bangladesh. This current study aims at the psychometric evaluation and validation of tertiary students' learning loss during the pandemic. A survey questionnaire is administered using the Likert scale. The components of the questionnaire are based on the Three-Domain Model reflecting the cognitive, affective, and psychomotor skills of the students. The article informs of the learning loss due to the pandemic while suggesting the benefits of online classes. The major finding of the article is that learners lost their skills mainly related to the cognitive domain during the pandemic due to online classes. However, at the same time, their skills related to affective and psychomotor domains increased. Therefore, recommendations for minimizing learning loss are also provided to guide future empirical work in the post-pandemic era

A PRECISE RP-HPLC METHOD DEVELOPMENT FOR THE SIMULTANEOUS ESTIMATION OF DIAZEPAM AND PROPRANOLOL HYDROCHLORIDE IN TABLET DOSAGE FORM

A simple, precise, and accurate RP – HPLC method was developed and validated for the simultaneous estimation of Diazepam and Propranolol Hydrochloride in bulk and tablet dosage form. Isocratic elution at a flow rate of 1.0 mL/min was employed on BDS Hypersil C18 (250 X 4.6 I.D., 5µm particle size) at ambient temperature. The mobile phase consisted of mixed buffer (0.02M potassium dihydrogen ortho phosphate and 0.003M dipotassium hydrogen phosphate, pH adjusted to 3.0) and acetonitrile (40:60v/v). The UV detection wavelength was 222nm and 20µL of sample was injected. The retention times of Diazepam and Propranolol Hydrochloride were 2.031min and 5.597min respectively. The linearity was obtained in the range of 2 – 12 µg/mL for diazepam and 16 – 96 µg/mL for propranolol hydrochloride. The mean % recovery of diazepam and propranolol hydrochloride was found to be 99.92, 99.94 respectively. The % RSD for precision and accuracy of the method was found to be less than 1%. The method was validated as per the ICH guidelines. The method developed was found to be precise and accurate for the simultaneous estimation of diazepam and propranolol hydrochloride in tablet dosage form

3D Bioprinted cancer models: Revolutionizing personalized cancer therapy

After cardiovascular disease, cancer is the leading cause of death worldwide with devastating health and economic consequences, particularly in developing countries. Inter-patient variations in anti-cancer drug responses further limit the success of therapeutic interventions. Therefore, personalized medicines approach is key for this patient group involving molecular and genetic screening and appropriate stratification of patients to treatment regimen that they will respond to. However, the knowledge related to adequate risk stratification methods identifying patients who will respond to specific anti-cancer agents is still lacking in many cancer types. Recent advancements in three-dimensional (3D) bioprinting technology, have been extensively used to generate representative bioengineered tumor in vitro models, which recapitulate the human tumor tissues and microenvironment for high-throughput drug screening. Bioprinting process involves the precise deposition of multiple layers of different cell types in combination with biomaterials capable of generating 3D bioengineered tissues based on a computer-aided design. Bioprinted cancer models containing patient-derived cancer and stromal cells together with genetic material, extracellular matrix proteins and growth factors, represent a promising approach for personalized cancer therapy screening. Both natural and synthetic biopolymers have been utilized to support the proliferation of cells and biological material within the personalized tumor models/implants. These models can provide a physiologically pertinent cell–cell and cell–matrix interactions by mimicking the 3D heterogeneity of real tumors. Here, we reviewed the potential applications of 3D bioprinted tumor constructs as personalized in vitro models in anticancer drug screening and in the establishment of precision treatment regimens

Chronic Salt Loading and the Expression of Adenosine Receptor Subtypes

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Angiotensin II stimulation alters vasomotor response to adenosine in mouse mesenteric artery: role for A1 and A2B adenosine receptors.

BACKGROUND AND PURPOSE: Stimulation of the A1 adenosine receptor and angiotensin II receptor type-1 (AT1 receptor) causes vasoconstriction through activation of cytochrome P450 4A (CYP4A) and ERK1/2. Thus, we hypothesized that acute angiotensin II activation alters the vasomotor response induced by the non-selective adenosine receptor agonist, NECA, in mouse mesenteric arteries (MAs). EXPERIMENTAL APPROACH: We used a Danish Myo Technology wire myograph to measure muscle tension in isolated MAs from wild type (WT), A1 receptor and A2B receptor knockout (KO) mice. Western blots were performed to determine the expression of AT1 receptors and CYP4A. KEY RESULTS: Acute exposure (15 min) to angiotensin II attenuated the NECA-dependent vasodilatation and enhanced vasoconstriction. This vasoconstrictor effect of angiotensin II in NECA-treated MAs was abolished in A1 receptor KO mice and in WT mice treated with the A1 receptor antagonist DPCPX, CYP4A inhibitor HET0016 and ERK1/2 inhibitor PD98059. In MAs from A2B receptor KO mice, the vasoconstrictor effect of angiotensin II on the NECA-induced response was shown to be dependent on A1 receptors. Furthermore, in A2B receptor KO mice, the expression of AT1 receptors and CYP4A was increased and the angiotensin II-induced vasoconstriction enhanced. In addition, inhibition of KATP channels with glibenclamide significantly reduced NECA-induced vasodilatation in WT mice. CONCLUSIONS AND IMPLICATIONS: Acute angiotensin II stimulation enhanced A1 receptor-dependent vasoconstriction and inhibited A2B receptor-dependent vasodilatation, leading to a net vasoconstriction and altered vasomotor response to NECA in MAs. This interaction may be important in the regulation of BP