New targets for resolution of airway remodeling in obstructive lung diseases.

Airway remodeling (AR) is a progressive pathological feature of the obstructive lung diseases, including asthma and chronic obstructive pulmonary disease (COPD). The pathology manifests itself in the form of significant, progressive, and (to date) seemingly irreversible changes to distinct respiratory structural compartments. Consequently, AR correlates with disease severity and the gradual decline in pulmonary function associated with asthma and COPD. Although current asthma/COPD drugs manage airway contraction and inflammation, none of these effectively prevent or reverse features of AR. In this review, we provide a brief overview of the features and putative mechanisms affecting AR. We further discuss recently proposed strategies with promise for deterring or treating AR

Evolution of Primordial Black Hole Mass Spectrum in Brans-Dicke Theory

We investigate the evolution of primordial black hole mass spectrum by including both accretion of radiation and Hawking evaporation within Brans-Dicke cosmology in radiation, matter and vacuum-dominated eras. We also consider the effect of evaporation of primordial black holes on the expansion dynamics of the universe. The analytic solutions describing the energy density of the black holes in equilibrium with radiation are presented. We demonstrate that these solutions act as attractors for the system ensuring stability for both linear and nonlinear situations. We show, however, that inclusion of accretion of radiation delays the onset of this equilibrium in all radiation, matter and vacuum-dominated eras.Comment: 18 pages, one figur

Evolution of Primordial Black Holes in Loop Quantum Gravity

In this work, we study the evolution of Primordial Black Holes within the context of Loop Quantum Gravity. First we calculate the scale factor and energy density of the universe for different cosmic era and then taking these as inputs we study evolution of primordial black holes. From our estimation it is found that accretion of radiation does not affect evolution of primordial black holes in loop quantum gravity even though a larger number of primordial black holes may form in early universe in comparison with Einstein's or scalar-tensor theories.Comment: 8 pages, 1 figur