Human protein reference database—2006 update

Human Protein Reference Database (HPRD) () was developed to serve as a comprehensive collection of protein features, post-translational modifications (PTMs) and protein–protein interactions. Since the original report, this database has increased to >20 000 proteins entries and has become the largest database for literature-derived protein–protein interactions (>30 000) and PTMs (>8000) for human proteins. We have also introduced several new features in HPRD including: (i) protein isoforms, (ii) enhanced search options, (iii) linking of pathway annotations and (iv) integration of a novel browser, GenProt Viewer (), developed by us that allows integration of genomic and proteomic information. With the continued support and active participation by the biomedical community, we expect HPRD to become a unique source of curated information for the human proteome and spur biomedical discoveries based on integration of genomic, transcriptomic and proteomic data

Crystal engineering and magnetic properties of a 2D cyano-bridged NiIIFeII network formed through reduction of ferricyanide

[[abstract]]Reaction of potassium ferricyanide with a mixture of nickel(II) chloride hexahydrate and trans-1,2-diaminocyclohexane (L) produces both a ferrocyanide ([NiIIL2]2[FeII(CN)6] · 5H2O (1)) and a ferricyanide ([NiII(L)2]3[FeIII(CN)6]2 · 2H2O (2)) compound. Clearly, the formation of 1 is accompanied by the reduction of ferricyanide to ferrocyanide. Interestingly, the relative amounts of the formation of 1 and 2 depends on the nickel(II):diamine ratio and the volume of the reaction mixture. It has been established from spectrophotometric titration that trans-1,2-diaminocyclohexane is responsible for the reduction of [Fe(CN)6]3− to [Fe(CN)6]4−. The ferrocyanide analogue, 1, can also be prepared by mixing potassium ferrocyanide with the nickel(II)-diamine solution. Among the six cyanides of each hexacyanoferrate(II), four coordinate to four different nickel(II) centers to form cyano-bridged two-dimensional square grids. The remaining two cyanides form strong hydrogen bonds with two hydrogens of one water of crystallization to result in squares, which can be considered as appended to the two-dimensional grids. The hydrogen bonds involving the hydrogens of amine groups of one 2D grid and the oxygens forming the appended squares of another 2D grid generate the third dimension of the structure. Variable-temperature (2–300 K) magnetic susceptibility measurements reveal that the nickel(II) centers in 1 are practically non-correlated.[[notice]]補正完

Hydrated hexacyanometallate(III) salts of triaqua(18-crown-6)lanthanoid(III) and tetraaqua(18-crown-6) lanthanoid(III) cations containing nine- and ten-coordinate lanthanoids

Tetraaqua( 18- crown- 6) cerium( III) hexacyanoferrate( III) dihydrate, [ Ce( C12H24O6)( H2O)(4)][ Fe( CN)(6)]center dot 2H(2)O, and tetraaqua( 18- crown- 6) neodymium( III) hexacyanoferrate( III) dihydrate, [ Nd( C12H24O6)( H2O)(4)][ Fe( CN)(6)] center dot 2H(2)O, are isomorphous and isostructural in the C2/ c space group, where the cations, which contain ten- coordinate lanthanoid centres, lie across twofold rotation axes and the anions lie across inversion centres. In these compounds, an extensive series of O - H center dot center dot center dot O and O - H center dot center dot center dot N hydrogen bonds links the components into a continuous three- dimensional framework. Triaqua( 18- crown- 6) lanthanoid( III) hexacyanoferrate( III) dihydrate, [ Ln( C12H24O6)( H2O)(3)][ Fe( CN)(6)]center dot 2H(2)O, where Ln = Sm, Eu, Gd or Tb, are all isomorphous and isostructural in the P (1) over bar space group, as are triaqua( 18- crown- 6) gadolinium( III) hexacyanochromate( III) dihydrate, [ Gd( C12H24O6)( H2O)(3)][ Cr( CN)(6)] center dot 2H(2)O, and triaqua( 18- crown- 6) gadolinium( III) hexacyanocobaltate( III) dihydrate, [ Gd( C12H24O6)( H2O)(3)][ Co( CN)(6)] center dot 2H(2)O. In these compounds, there are two independent anions, both lying across inversion centres, and the lanthanoid centres exhibit nine- coordination; in the crystal structures, an extensive series of hydrogen bonds links the components into a three- dimensional framework.</p

Hydrated hexacyanometallate(III) salts of triaqua(18-crown-6)lanthanoid(III) and tetraaqua(18-crown-6) lanthanoid(III) cations containing nine- and ten-coordinate lanthanoids

Tetraaqua( 18- crown- 6) cerium( III) hexacyanoferrate( III) dihydrate, [ Ce( C12H24O6)( H2O)(4)][ Fe( CN)(6)]center dot 2H(2)O, and tetraaqua( 18- crown- 6) neodymium( III) hexacyanoferrate( III) dihydrate, [ Nd( C12H24O6)( H2O)(4)][ Fe( CN)(6)] center dot 2H(2)O, are isomorphous and isostructural in the C2/ c space group, where the cations, which contain ten- coordinate lanthanoid centres, lie across twofold rotation axes and the anions lie across inversion centres. In these compounds, an extensive series of O - H center dot center dot center dot O and O - H center dot center dot center dot N hydrogen bonds links the components into a continuous three- dimensional framework. Triaqua( 18- crown- 6) lanthanoid( III) hexacyanoferrate( III) dihydrate, [ Ln( C12H24O6)( H2O)(3)][ Fe( CN)(6)]center dot 2H(2)O, where Ln = Sm, Eu, Gd or Tb, are all isomorphous and isostructural in the P (1) over bar space group, as are triaqua( 18- crown- 6) gadolinium( III) hexacyanochromate( III) dihydrate, [ Gd( C12H24O6)( H2O)(3)][ Cr( CN)(6)] center dot 2H(2)O, and triaqua( 18- crown- 6) gadolinium( III) hexacyanocobaltate( III) dihydrate, [ Gd( C12H24O6)( H2O)(3)][ Co( CN)(6)] center dot 2H(2)O. In these compounds, there are two independent anions, both lying across inversion centres, and the lanthanoid centres exhibit nine- coordination; in the crystal structures, an extensive series of hydrogen bonds links the components into a three- dimensional framework.</p