Luxación acromio-clavicular posterior con fractura clavicular asociada

Se presenta un caso infrecuente de luxación acromio- clavicular posterior asociada a una fractura de tercio medio clavicular ipsilateral en un varón de 17 años. El diagnóstico se basa en la sospecha clínica y en las pruebas de imagen, siendo la TAC de particular utilidad. La reducción abierta y fijación coraco-clavicular con resección del extremo distal clavicular dio excelentes resultados. Se compara el tratamiento realizado con otros publicados, realizando una revisión de la literatura al respecto.An unusual case of combined posterior acromioclavicular joint dislocation and an ipsilateral fracture of the middle third of the clavicle in a 17-year-old male is presented. Diagnosis is based on clinical suspicion and imaging test, being CT scan particularly useful. Open reduction and coracoclavicular fixation with excision of the distal clavicle led to successful results. Treatment is compared with previous reports. A review of the literature is made

Fuzzy role-based access control

RBAC (Role-Based Access Control) is a widely used access control model, which reduces the maintenance cost of classical identity-based access control. However, despite the benefits of RBAC, there are environments in which RBAC can hardly be applied. We present FRBAC (Fuzzy Role-Based Access Control), a generalization of RBAC through fuzzy relations that extends the applicability of RBAC to environments where authorization-related information is vague. Moreover, FRBAC deals with environments where the actions that can be executed over the resources have a fractional meaning, as data lying in databases and risk-based access control

The Potential of Proteolytic Chimeras as Pharmacological Tools and Therapeutic Agents

The induction of protein degradation in a highly selective and efficient way by means of druggable molecules is known as targeted protein degradation (TPD). TPD emerged in the literature as a revolutionary idea: a heterobifunctional chimera with the capacity of creating an interaction between a protein of interest (POI) and a E3 ubiquitin ligase will induce a process of events in the POI, including ubiquitination, targeting to the proteasome, proteolysis and functional silencing, acting as a sort of degradative knockdown. With this programmed protein degradation, toxic and disease-causing proteins could be depleted from cells with potentially effective low drug doses. The proof-of-principle validation of this hypothesis in many studies has made the TPD strategy become a new attractive paradigm for the development of therapies for the treatment of multiple unmet diseases. Indeed, since the initial protacs (Proteolysis targeting chimeras) were posited in the 2000s, the TPD field has expanded extraordinarily, developing innovative chemistry and exploiting multiple degradation approaches. In this article, we review the breakthroughs and recent novel concepts in this highly active discipline

Osteocondritis de los sesamoideos del hallux: revisión de la literatura a propósito de un caso

La osteocondritis de los sesamoideos del hallux es una afección poco frecuente que puede afectar tanto al sesamoideo medial como al lateral. Presentamos un caso de osteocondritis del sesamoideo externo en una mujer de 27 años, con clínica de dolor de un año de evolución, que se resolvió satisfactoriamente con la excisión quirúrgica del mismo. Comparamos el tratamiento realizado con otros publicados, realizando una revisión de la literatura con respecto a sus causas, los métodos diagnósticos y los tratamientos empleados.Osteochondritis of the sesamoid bones is an unfrequent condition wich may affect both the medial and lateral hallux sesamoids. We report a case of osteochondritis of the external sesamoid in a 27 years old woman, with a one year clinical pain evolution, wich was satisfactory solved by carrying out its surgical excision. We compare the treatment carried out with others that have been published, reviewing the literature that refers to its causes, the diagnostic methods and treatment use

Skill development in experimental courses

Experimental courses offer a good opportunity to work with competences, promoting the incorporation of strategies oriented towards motivating students to actively involve in the learning process, promoting reflexive learning and developing generic skills. This study presents different ways of developing and evaluating some important general skills, settle on four specific objectives: 1. To increase student motivation using samples of potential interest to students and explaining real-live application of their samples analyses; 2. To assist students' self-regulation and learning autonomy by using the portfolio; 3. To promote group work through experiments in pairs and small-group discussions; 4. To develop communication skills through small-group discussions and oral presentations. Results show that the type of sample used and real-life application has important influence on motivation. The portfolio is a good tool to promote reflection and to evaluate both specific and generic skills in experimental courses, the dynamics of a laboratory course permit students to develop their group-work and communicative skills, and peer evaluations both improve students' communication skills and promote metacognitive reflection. Finally, the project demonstrates that it is possible to train students in general skills using the specific course content and that the incorporation of participatory methodologies encourages students to become actively involved in the teaching-learning process

Subunits Common to RNA Polymerases

RNA polymerases are heteromultimeric complexes responsible of RNA synthesis. In yeast, as in the other eukaryotes, these complexes contain five common subunits (Rpb5, Rpb6, Rpb8, Rpb10 and Rpb12) that must have similar functions in the three RNA polymerases. However, some of these proteins have been shown to also have specific roles. In the last few decades, substantial progress has been made to understand the role of these common subunits in transcription, but their participation in the activity of each enzyme remains unclear. This review gives a comprehensive overview of current knowledge on the five common subunits of eukaryotic RNA pol, placing attention not only on their common roles in the activity of the RNA pols but also on describing specific roles for some of the complexes

PSresin for the analysis of alpha-emitting radionuclides: Comparison of diphosphonic acid-based extractants

The analysis of radionuclides is complex, with high economic and time costs. For this reason, there is a need to develop new methods and strategies to reduce these costs. One important group in the analysis of radionuclides is the actinides, which are the main constituents assessed in the total gross alpha together with radium and radon test used to measure radioactivity in drinking water. Moreover, in nuclear dismantling processes, the possible spread of the released radionuclides has to be controlled, which is measured by many techniques, depending on the radionuclides, through scintillation. This work presents a new method to analyse actinides using plastic scintillation resins (PSresins) packed in a solid-phase extraction cartridge. The proposed method combines chemical separation and sample measurement into a single step, reducing the effort, time and reagents required for analysis as well as decreasing the amount of waste generated. The PSresins compared in this study contained three selective extractants based on Methylenediphosphonic acid with different radicals, which has a high affinity for tri-, tetra-, and hexavalent actinides in dilute acids. These extractants were immobilised on plastic scintillation microspheres at a ratio of 1/1:6, producing a retention and detection efficiency of 100% for 241Am, 230Th, Uranium and 238Pu. The retention and detection efficiency were 20% and 100%, respectively, for 210Po and low for 226Ra

Influencia de la temperatura de almacenamiento, encerado, preacondicionado y curado en la calidad del tangelo minneola

El tangelo Minneola (citrus paradisi Duncan x citrus reticulata Dancy), tiene buen tamaño y coloración naranja-rojiza. El objeto de este trabajo es el estudio de la efectividad de las bajas temperaturas (1º, 5º, 7º y 9º), encerado (5% polietileno + 5% resinas), preacondicionado (PA) a media temperatura y curado (Q) en la conservación dela calidad. La fruta fue almacenada dos años consecutivos durante 30 y 40 días más 7 días a 20%C simulando el periodo de almacenamiento y posterior comercialización. Se determinaron cambios en: peso, firmeza, color (IC), porcentaje de zumo, sólidos solubles (TSS), acidez (TA), atmósfera interna, volátiles en Zumo, sabor, comestibilidad y alteraciones fisiológicas. No se detectaron diferencias significativas en IC y porcentaje de zumo. TA disminuyó durante la conservación y la deformación ecuatorial incrementó correlacionándose con las pérdidas de humedad. Se observó un mayor porcentaje de etanol en frutos encerados. El menor contenido de este parámetro fue para los tratamientos de PA y Q. Respecto a las características organolépticas las puntuaciones iniciales fueron similares en ambas campañas. En 1999 estos valores se mantuvieron estables en comestibilidad y descendieron en sabor en mayor medida en los frutos encerados. En el 2000 el descenso se produjo en ambos parámetros llegándose a detectar malos sabores. En el año 99, el tangelo Minneola mostró susceptibilidad a los daños por frío (DF) incluso a 9"C. El encerado fue efectivo en la reducción de los mismos. En el 2000 no se observaron DF significativos en ninguno delos tratamientos. Parece que 5”C es la mejor temperatura de almacenamiento para conservar una calidad aceptable durante 40 días. La utilización de PA y Q para prevenir DF no afecta negativamente a los parámetros de calidad