Online Deaf Resources: Deaf Artists, Deaf and WW II, and Deaf Theatre

NTID, a college at RIT, has freely available Deaf related resources related to Deaf Art, Deaf History and Deaf Theatre. Discussion will center around how librarians can support the development of Deaf curricula through content related research, copyright awareness and more

Sculptures in the Air: ASL Poetry and Literature Collections at RIT/NTID Deaf Studies Archive, Rochester, NY

Rochester Institute of Technology (RIT) Libraries is digitizing 61 videotapes held in the RIT/NTID DSA that document the ASL literature movement in Rochester from 1970-2011. These videotapes represent the largest collection of rare U.S. ASL Literature to be made publically accessible. Preservation digital copies will be made and stored, and access to digital copies provided for use by scholars and the general public. This collection will be universally accessible: it will be captioned, voiced, transcribed and/or signed. The once “hidden” work of this pioneering and under-represented group will be made public for the first time, broadening access to the cultural heritage of this diverse group little known outside of the Deaf community and enriching interdisciplinary studies in linguistics, poetry, performing arts, and cinema. This project can shape a new understanding of libraries’ important role in modeling best practices for accessible sharing of online videos through the Council of Library and Information Resources (CLIR) grant

Finding Hidden Treasures: Research Help in the Library and Archives

At the 2009 Deaf History International Conference, Ulf Hedberg spoke on the preservation of Deaf materials. The objective was to promote the preservation of Deaf materials by individuals, institutions, and organizations and to encourage the donation of Deaf materials to libraries, archives, museums, or organizations. In this chapter our objective is to identify the numerous resources at the Gallaudet University Library Deaf Collections and Archives and the Rochester Institute of Technolo-gy’s (RIT) Wallace Library, which are now on the Internet. The resources discussed here contain biographical materials that relate to this book’s theme of telling Deaf lives. Since the year 2012, when the Eighth Deaf History International conference was hosted, was the three-hundredth anniversary of the Abbé de l’Épée’s birth, several de l’Épée resources are identified. Many of the materials mentioned from the Gallaudet Univer-sity Library Deaf Collections and Archives were made accessible online thanks to a generous grant from the Mellon Foundation

Seeing the World Through Deaf Eyes: Chile Study-Abroad Experiences of Deaf Students

Research has indicated that a global education, including study-abroad programs, is increasingly crucial in today’s world and offers intercultural, personal, academic, and career-related benefits to participants. However, there has been a paucity of academic research on best-class and study-abroad program designs for the deaf and hard-of-hearing students. The research to date has not included the experiences and perceptions of deaf students who participated in study-abroad programs. The purpose of this study was to examine the perceived supports and barriers to study-abroad experiences of deaf students. Information gathered from the unique perspective of deaf study participants was used to assist in designing optimal classes and study-abroad programs that consider the cultural, visual, and linguistic needs of these students. This study incorporates Yosso’s community cultural wealth theory and investigates how deaf study participants develop social, familial, aspirational, linguistic, navigational, intercultural, and/or resistant capital, which are components of community cultural wealth (Listman, Rogers, & Hauser, 2011; Yosso, 2005, 2006). The researcher employed a qualitative methodology, specifically, phenomenology. Interviews were conducted with participants who are deaf students and have experienced study-abroad programs using the direct signing model. The phenomenon of interest is the sign-accessible Chile abroad experience of deaf students. Interview questions exploring the development of various capital were also asked (Listman et al., 2011; Yosso, 2005, 2006). At the conclusion of the study, the researcher viii recommends best practices in class- and study-abroad program designs from the deaf students’ perspectives

Under one roof : hybrid architecture for Auckland

This project is an attempt to answer the question: How can the design of a mixed-use high-rise building provide a solution to urban sprawl and increase sustainability? The exponential growth of the human population globally has directly resulted in urban sprawl in many cities around the world. Trying to accommodate this ever-increasing growth gives rise to an unsustainable living solution. A shortage of obtainable land for expansion and an escalation in real estate prices has steered planners to mixed-use buildings to solve multiple issues currently faced by the 21st-century city. In architecture, the mixed-use building is a typology that existed since the formation of the city-states. With the utilization of zoning plans in the 19th century, due to the beginning of the industrial era and the introduction of modern town planning, the mixed-use building was used to supplement the limitations of an indisputably limited land base. The thought behind it was that the vertical expansion would help in saving energy resources, support the ever-increasing population and prevent the further eradication of farmlands, nature, and recreation thereby ensuring sustainability. The development of mixed-use buildings gave rise to an exploration of the potential and the opportunities that these types of structures can provide in relation to their placed context. This research, therefore, investigates the process of hybrid typology analysis in the context of the city as a first principle aid to produce mixed-use architecture. Through the research of related literature and precedents, a defined methodology with a focus on analysis and synthesis will assist in the development of a series of mixed-use interventions that go beyond the current understanding of mixed-use building development and how it can be sustainable. Hence this proposition of a productive and powerful mixed-use development is a beneficial point of research. However, this unification of variety as far as "form and function" should be situated in a comprehension of history, hypotheses, and points of reference of pertinent typologies. The aims and objectives, the philosophy and eventually the exploration question, which will be outlined in this explanatory document. The project can technically be located in any definitive urban area in the world facing this issue, but an area of downtown in Auckland. New Zealand was chosen as the site for this research. Ultimately this research provides insights into how a productive and powerful mixed-use development with a focus on sustainability can contribute to the urban fabric of contemporary 21st-century cities

Approches radicalaires pour la fonctionnalisation directe de quinones à visée anticancereuse

Dans le cadre d un programme de recherche dédié à la découverte de petites molécules à visée anticancéreuse, nous avons envisagé de concevoir des composés originaux dérivés de quinones. Notre premier objectif a été d élaborer des mimes non-peptidiques de la protéine Smac, susceptibles de participer à relancer le phénomène d apoptose, dont la structure est rigidifiée par des contraintes conformationnelles. Par ailleurs, les kinases et les phosphatases, jouant des rôles complémentaires de phosphorylation / déphosphorylation dans le cadre du contrôle du cycle cellulaire notamment, apparaissent aussi comme des cibles intéressantes. Une étude attentive de leurs inhibiteurs connus nous a permis de mettre en avant des analogies structurales qui nous ont conduit à vouloir synthétiser des motifs fonctionnalisés de dérivés de naphtoquinones.L introduction directe de chaînes latérales aliphatiques sur nos substrats, par création de liaisons de type C(sp2) C(sp3), a été rendue possible grâce au développement d une méthodologie de décarboxylation radicalaire. Dans les conditions réactionnelles mises au point, le couple Ag(I)/S2O82- est utilisé comme initiateur radicalaire et autorise la génération de radicaux alkyles par décarboxylation d acides aminés. L introduction directe de cycles aromatiques fonctionnalisés, via la création de liaisons de type C(sp2) C(sp2), a été réalisée par l intermédiaire de la génération de radicaux aryles issus de sels de diazonium stables ou d anilines. Les procédés décrits dans ce manuscrit nous ont permis d apporter certains éclaircissements sur la réactivité des substrats et sur les mécanismes réactionnels impliqués.In our ongoing course dedicated to the discovery of small anticancer molecules, we designed novel quinone derivatives. Our first objective was to fashion non-peptidic Smac mimics, able to trigger apoptosis in tumor cells, displaying a structure rigidified by conformational restrictions. Otherwise, the kinases and the phosphatases, acting as phosphorylating / dephosphorylating agents mostly in the control of the cell cycle, were thought to be other relevant biological targets. An intent study of their known inhibitors allowed us to underline trends in their chemical structure and made us plan the synthesis of functionalized naphthoquinones.A dedicated approach involving radical decarboxylation of amino acids allowed the introduction of aliphatic side chains on our substrates though C(sp2) C(sp3) bond formation. Ag(I)/S2O82- was used as alkyl radical initiator and the direct C-H alkylation of the quinonic positions could take place. C(sp2) C(sp2) bonds were created through aryl radicals generation from stable diazonium salts or anilines which allowed the direct C-H arylation of quinones. The procedures described along this manuscript let us formulate several advances on the substrates reactivity and on the reaction mechanisms involved.BORDEAUX1-Bib.electronique (335229901) / SudocSudocFranceF

Health Websites: Accessibility and Usability for American Sign Language Users

To date, there have been efforts towards creating better health information access for Deaf American Sign Language (ASL) users. However, the usability of websites with access to health information in ASL has not been evaluated. Our paper focuses on the usability of four health websites that include ASL videos. We seek to obtain ASL users’ perspectives on the navigation of these ASL-accessible websites, finding the health information that they needed, and perceived ease of understanding ASL video content. ASL users (N=32) were instructed to find specific information on four ASL-accessible websites, and answered questions related to: 1) navigation to find the task, 2) website usability, and 3) ease of understanding ASL video content for each of the four websites. Participants also gave feedback on what they would like to see in an ASL health library website, including the benefit of added captioning and/or signer model to medical illustration of health videos. Participants who had lower health literacy had greater difficulty in finding information on ASL-accessible health websites. This paper also describes the participants’ preferences for an ideal ASL-accessible health website, and concludes with a discussion on the role of accessible websites in promoting health literacy in ASL users

Separable mechanisms drive local and global polarity establishment in the Caenorhabditis elegans intestinal epithelium

Apico-basolateral polarization is essential for epithelial cells to function as selective barriers and transporters, and to provide mechanical resilience to organs. Epithelial polarity is established locally, within individual cells to establish distinct apical, junctional and basolateral domains, and globally, within a tissue where cells coordinately orient their apico-basolateral axes. Using live imaging of endogenously tagged proteins and tissue-specific protein depletion in the Caenorhabditis elegans embryonic intestine, we found that local and global polarity establishment are temporally and genetically separable. Local polarity is initiated prior to global polarity and is robust to perturbation. PAR-3 is required for global polarization across the intestine but local polarity can arise in its absence, as small groups of cells eventually established polarized domains in PAR-3-depleted intestines in a HMR-1 (E-cadherin)dependent manner. Despite the role of PAR-3 in localizing PKC-3 to the apical surface, we additionally found that PAR-3 and PKC-3/ aPKC have distinct roles in the establishment and maintenance of local and global polarity. Taken together, our results indicate that different mechanisms are required for local and global polarity establishment in vivo

New Trends in Migraine Pharmacology: Targeting Calcitonin Gene–Related Peptide (CGRP) With Monoclonal Antibodies

Migraine is a common neurologic disorder characterized by attacks consisting of unilateral, throbbing headache accompanied by photophobia, phonophobia, and nausea which remarkably reduces the patients’ quality of life. Not migraine-specific non-steroidal anti-inflammatory drugs (NSAIDs) are effective in patients affected by mild episodic migraine whilst in moderate or severe episodic migraine and in chronic migraineurs triptans and preventative therapies are needed. Since these treatments are endowed with serious side effects and have limited effectiveness new pharmacological approaches have been investigated. The demonstrated pivotal role of calcitonin gene-related peptide (CGRP) has fostered the development of CGRP antagonists, unfortunately endowed with liver toxicity, and monoclonal antibodies (mAbs) toward circulating CGRP released during migraine attack or targeting its receptor. Currently, four mAbs, eptinezumab, fremanezumab, galcanezumab for CGRP and erenumab for CGRP canonical receptor, have been studied in clinical trials for episodic and chronic migraine. Apart from the proven effectiveness, these antibodies have resulted well tolerated and could improve the compliance of the patients due to their long half-lives allowing less frequent administrations. This study aims at investigating the still poorly clear pathogenesis of migraine and the potential role of anti-CGRP mAbs in the scenario of prophylaxis of migraine