601 research outputs found
Biodiversity Conservation Planning in Rural Landscapes in Japan: Integration of Ecological and Visual Perspectives
Step Bunching with Alternation of Structural Parameters
By taking account of the alternation of structural parameters, we study
bunching of impermeable steps induced by drift of adatoms on a vicinal face of
Si(001). With the alternation of diffusion coefficient, the step bunching
occurs irrespective of the direction of the drift if the step distance is
large. Like the bunching of permeable steps, the type of large terraces is
determined by the drift direction. With step-down drift, step bunches grows
faster than those with step-up drift. The ratio of the growth rates is larger
than the ratio of the diffusion coefficients. Evaporation of adatoms, which
does not cause the step bunching, decreases the difference. If only the
alternation of kinetic coefficient is taken into account, the step bunching
occurs with step-down drift. In an early stage, the initial fluctuation of the
step distance determines the type of large terraces, but in a late stage, the
type of large terraces is opposite to the case of alternating diffusion
coefficient.Comment: 8pages, 16 figure
Molecules participating in insect immunity of Sarcophaga peregrina
Pricking the body wall of Sarcophaga
peregrina (flesh fly) larvae with a needle activated the immune system of this insect and induced various immune molecules, including antibacterial proteins, in the hemolymph. In this review, I summarize and discuss the functions of these immune molecules, with particular emphasis on the dual roles of some of these molecules in defense and development
Activation of latent ribonuclease in the fat-body of fleshfly (Sarcophaga peregrina) larvae on pupation
Unequal effects of renin-angiotensin system inhibitors in acute cardiac dysfunction induced by isoproterenol
Ohta, T; Hasebe, N; Tsuji, S; Izawa, K; Jin, YT; Kido, S; Natori, S; Sato, M; Kikuchi, K, AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 287(6), H2914-H2921, 2004. "Copyright 2004 by the American Physical Society."
publisherSeveral clinical trials have demonstrated that angiotensin-converting enzyme inhibitor (ACEI) and angiotensin II type 1 receptor blocker (ARB) are equally effective in the treatment of chronic heart failure. However, this has not been confirmed for acute cardiac dysfunction. We examined whether ACEI or ARB prevents isoproterenol-induced acute left ventricular (LV) dysfunction in dogs. LV dysfunction induced by a large dose of isoproterenol (1 µg·kg^–1·min^–1, 3-h infusion) was compared in dogs treated with ACEI (temocaprilat) or ARB (olmesartan). Atrial pacing induced a constant heart rate and use of adjustable aortic banding provided a nearly constant afterload. LV systolic function (LV dP/dt, fractional shortening, and ejection fraction) and diastolic function (γ and LV end-diastolic pressure) were significantly deteriorated after isoproterenol infusion. The LV dysfunction was almost totally prevented by ARB but was only partially prevented by ACEI. The partial effect of ACEI was complemented by cotreatment with HOE-140, a bradykinin B_2 receptor antagonist. At baseline, the response to low doses of isoproterenol was significantly attenuated by ACEI but not by ARB, and the ACEI-induced attenuation was totally abolished by cotreatment with HOE-140. The response to isoproterenol was significantly attenuated after 3 h of excess isoproterenol loading, and it was almost completely preserved by ARB but not by ACEI. In conclusion, acute LV dysfunction and β-adrenergic desensitization induced by excess isoproterenol administration were almost totally prevented by ARB but only partially prevented by ACEI. These differences were attributable at least in part to bradykinin pathways activated by ACEI administration in acute LV dysfunction
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