Probiotics [LGG-BB12 or RC14-GR1] versus placebo as prophylaxis for urinary tract infection in persons with spinal cord injury [ProSCIUTTU]: a randomised controlled trial

© 2019, The Author(s). Study design: Randomised double-blind factorial-design placebo-controlled trial. Objective: Urinary tract infections (UTIs) are common in people with spinal cord injury (SCI). UTIs are increasingly difficult to treat due to emergence of multi-resistant organisms. Probiotics are efficacious in preventing UTIs in post-menopausal women. We aimed to determine whether probiotic therapy with Lactobacillus reuteri RC-14+Lactobacillus GR-1 (RC14-GR1) and/or Lactobacillus rhamnosus GG+Bifidobacterium BB-12 (LGG-BB12) are effective in preventing UTI in people with SCI. Setting: Spinal units in New South Wales, Australia with their rural affiliations. Methods: We recruited 207 eligible participants with SCI and stable neurogenic bladder management. They were randomised to one of four arms: RC14-GR1+LGG-BB12, RC14-GR1+placebo, LGG-BB12+ placebo or double placebos for 6 months. Randomisation was stratified by bladder management type and inpatient or outpatient status. The primary outcome was time to occurrence of symptomatic UTI. Results: Analysis was based on intention to treat. Participants randomised to RC14-GR1 had a similar risk of UTI as those not on RC14-GR1 (HR 0.67; 95% CI: 0.39–1.18; P = 0.17) after allowing for pre-specified covariates. Participants randomised to LGG-BB12 also had a similar risk of UTI as those not on LGG-BB12 (HR 1.29; 95% CI: 0.74–2.25; P = 0.37). Multivariable post hoc survival analysis for RC14-GR1 only vs. the other three groups showed a potential protective effect (HR 0.46; 95% CI: 0.21–0.99; P = 0.03), but this result would need to be confirmed before clinical application. Conclusion: In this RCT, there was no effect of RC14-GR1 or LGG-BB12 in preventing UTI in people with SCI

Conference Proceedings, The International Conference on Aging, Disability and Independence acknowledges the financial support of NIDRR, (February 20-23, 2008) St. Petersburg, FL USA

iii, 220 hal.: 25 cm

Conference Proceedings, The International Conference on Aging, Disability and Independence acknowledges the financial support of NIDRR, (February 20-23, 2008) St. Petersburg, FL USA

iii, 220 hal.: 25 cm

Digest of data on persons with disabilities /

"January 1992.""U.S. Department of Education contract number MR890210-03."Includes bibliographical references (p. 47-52).Mode of access: Internet

Disability in the United States : prevalence and causes, 1992 /

"August 1996"--Cover."July 1996.""Prepared with funding from the National Institute on Disability and Rehabilitation Research under Award number H133B30002."Includes bibliographical references (p. 52).Mode of access: Internet

Compendium of products by NIDRR grantees & contractors.

"ED/OSERS."Title from cover.Mode of access: Internet.Produced by the National Rehabilitation Information Center (NARIC)

Families with disabilities in the United States /

"September 1996.""Prepared with funding from the National Institute on Disability and Rehabilitation Research under award number H133B3000Z."Includes bibliographical references (p. 15).Mode of access: Internet