Novel non-operative treatment of uterovaginal prolapse in a preterm neonate

Uterovaginal prolapse (UVP) is a rare condition that occurs in neonates. The case report presented here details an extremely rare, and potentially unique, occurrence of UVP in a premature infant whose prolapse was found to be secondary to an anatomical cause. The preterm newborn developed UVP three weeks after birth. Further investigation identified a bicornuate uterus and an ovarian mucus cyst that was likely secondary to the effect of maternal hormones upon the infant. A conservative and novel management method, using a feeding nipple/sterilized gauze soaked with petroleum jelly, and continuous monitoring, helped resolve the UVP. As a result of this case and our experience in diagnosing and treating UVP, we created a flowchart (included herein) for the diagnosis of UVP in newborns, including those who are premature

Maternal diabetes mellitus as an independent risk factor for clinically significant retinopathy of prematurity severity in neonates less than 1500g.

BackgroundRetinopathy of prematurity (ROP) is a significant morbidity in preterm babies. Multiple risk factors for severe ROP have been extensively studied, however, only a few studies have included maternal diabetes mellitus (MDM) in their assessment. ROP and diabetic retinopathy are both retinal vascular diseases in which there is leakage and/or neovascularization from damaged retinal vessels. Diabetes may affect ROP development; however, there are conflicting results on the association between MDM and ROP.ObjectiveTo determine if MDM is an independent risk factor for clinically significant ROP (ROP > Stage II) in neonates weighing less than 1500g.Design/methodWe conducted a retrospective cohort study of neonates weighing ResultsWe extracted 883 paired maternal-neonatal data. The mean (standard deviation) gestational age and birthweight were 28.5 (2.9) weeks and 1052.7 (300.9) grams, respectively. Of the 883 mothers, 72 (8.2%) had DM. The incidence of ROP and severe ROP was 42.4% (374/883) and 6.5% (57/883) respectively. The odds ratio comparing MDM and severe ROP was 3.47 [95% CI: 1.51-7.96]; pConclusionMaternal diabetes is associated with ROP and the strength of association increased with increasing severity of ROP