Signalling hostility: The relationship between witnessing weight-based discrimination in medical school and medical student wellbeing

Environments that are hostile to one or more marginalised groups are known to have a negative effect on the mental health and wellbeing of both targets and observers. Anti-fat attitudes have been well documented in medical education, including the use of derogatory humour and discriminatory treatment towards higher-weight patients. However, to date, it is not known what effect observing weight stigma and discrimination during medical school has on medical students’ psychological health and wellbeing, sense of belonging, and medical school burnout. The present study surveyed a total of 3,994 students enrolled across 49 US medical schools at the start of their first year and at the end of their fourth year. Participants reported the frequency with which they had observed stigmatising and discriminatory behaviours targeted at both higher-weight patients and higher-weight students during their four years of medical school. Observed weight stigma was prevalent, and was associated with worse psychological and general health, reduced medical school belonging and increased medical school burnout. The indirect effects of observed weight stigma on medical school burnout, via belonging, psychological health, and general health, were statistically significant in the sample as a whole, but were more pronounced in higher-weight students. This effect may be explained, in part, by the relationship between observed stigma and medical school belonging. Higher levels of observed stigma were associated with reduced feelings of belonging in higher-weight but not normative-weight students. Top-down institutional culture change is needed to rectify this situation, which is detrimental to both students and patients

On-target, dual aminopeptidase inhibition provides cross-species antimalarial activity

To combat the global burden of malaria, development of new drugs to replace or complement current therapies is urgently required. Here, we show that the compound MMV1557817 is a selective, nanomolar inhibitor of both Plasmodium falciparum and Plasmodium vivax aminopeptidases M1 and M17, leading to inhibition of end-stage hemoglobin digestion in asexual parasites. MMV1557817 can kill sexual-stage P. falciparum, is active against murine malaria, and does not show any shift in activity against a panel of parasites resistant to other antimalarials. MMV1557817-resistant P. falciparum exhibited a slow growth rate that was quickly outcompeted by wild-type parasites and were sensitized to the current clinical drug, artemisinin. Overall, these results confirm MMV1557817 as a lead compound for further drug development and highlights the potential of dual inhibition of M1 and M17 as an effective multi-species drug-targeting strategy

Perceptions of Caring and Mental Health in LGBTQ+ Youth in Foster Care

We compared the relationship between foster care and psychopathology in LGBTQ+ and cisgender, heterosexual youth. We also compared perceptions of caring, and the relationship between these perceptions and psychopathology, in LGBTQ+ and cisgender, heterosexual youth in foster care. Foster care was more consistently linked to psychopathology among cisgender, heterosexual youth than LGBTQ+ youth, who had more psychopathology overall. Perceptions of caring, which were lower in LGBTQ+ than cisgender heterosexual foster youth, were associated with reduced psychopathology. Even when controlling for perceptions of caring, however, LGBTQ+ identity had a negative effect on psychopathology among youth in foster care