Returns to Education and Education-Occupation Mismatch within a Transition Economy. Empirical Analysis for the Russian Federation

This paper makes a thorough analysis of the returns to tertiary education and education-occupation matches within a transition economy and compares these returns to similar returns in a developed economy. This study shows through the example of the Russian Federation that the increase in the returns to education which happened in previous years does not indicate that the labor market is becoming closer to that of developed countries. The standard estimation of the returns to education is deconstructed in three parts characterizing the labor market : education-occupation match, payment for occupations and payment for productivity within occupations. First, I compare the non-parametric estimation of wage distributions by educational and occupational groups within the Russian labor market and a developed country's labor market (I take France as an example). Second, I estimate a joint reduced-form model of the educational choice, labor market participation, placement of employees among occupational categories and wage formation. This joint model allows us to take into account correlations between unobservable factors that simultaneously influence the educational choice, occupational choice and final wage. A wide range of explanatory variables is used, characterizing not only individuals, but also their households, job, industries of work and regions. This allows us to analyze the influence of the family's network on the placements among occupational categories and wage formation. I take into account the observed heterogeneity of returns to education among the analyzed population. The results show the advantages of the proposed approach for the analysis of transition labor markets when compared with the standard approaches to transition economies.Returns to education, occupational choice, transition economy.

Returns to Education and Education-Occupation Mismatch within a Transition Economy. Empirical Analysis for the Russian Federation

URL des Documents de travail : http://ces.univ-paris1.fr/cesdp/CESFramDP2010.htmDocuments de travail du Centre d'Economie de la Sorbonne 2010.31 - ISSN : 1955-611XThis paper makes a thorough analysis of the returns to tertiary education and education-occupation matches within a transition economy and compares these returns to similar returns in a developed economy. This study shows through the example of the Russian Federation that the increase in the returns to education which happened in previous years does not indicate that the labor market is becoming closer to that of developed countries. The standard estimation of the returns to education is deconstructed in three parts characterizing the labor market : education-occupation match, payment for occupations and payment for productivity within occupations. First, I compare the non-parametric estimation of wage distributions by educational and occupational groups within the Russian labor market and a developed country's labor market (I take France as an example). Second, I estimate a joint reduced-form model of the educational choice, labor market participation, placement of employees among occupational categories and wage formation. This joint model allows us to take into account correlations between unobservable factors that simultaneously influence the educational choice, occupational choice and final wage. A wide range of explanatory variables is used, characterizing not only individuals, but also their households, job, industries of work and regions. This allows us to analyze the influence of the family's network on the placements among occupational categories and wage formation. I take into account the observed heterogeneity of returns to education among the analyzed population. The results show the advantages of the proposed approach for the analysis of transition labor markets when compared with the standard approaches to transition economies.Le papier analyse dans un premier temps le rendement de l'éducation et l'appariement éducation-occupation dans une économie en transition. Puis, dans un second temps, l'article compare les caractéristiques du marché du travail russe, que l'augmentation du rendement de l'éducation ne garantit pas que le fonctionnement des marchés du travail des pays en transition se rapproche de celui des pays développés. L'estimation standard du rendement de l'éducation est réalisée en considérant trois aspects du marché du travail : l'appariement éducation-occupation, le rendement des catégories socioprofessionnelles et la rémunération des différents niveaux de productivité au sein même des catégories socioprofessionnelles. Dans un premier temps, les estimations non-paramétriques des distributions des salaires en Russie et en France sont comparées. Puis, un modèle joint sous forme réduite est utilisé pour estimer les choix éducatifs, la participation au marché du travail, le choix des catégories socioprofessionnelles et des salaires. Ce modèle joint nous permet de prendre en compte les facteurs non observables qui influencent simultanément le choix d'éducation, le choix d'occupation et les salaires. Une grande variété de variables explicatives est utilisée, notamment celles qui caractérisent non seulement les individus, mais aussi leur famille, leur travail, les industries et les régions. Cela nous permet aussi d'analyser l'infuence des réseaux familiaux sur le choix des catégories socioprofessionnelles et des salaires. L'hétérogénéité observable des rendements de l'éducation dans la population analysée est alors prise en compte. Les résultats montrent l'avantage de l'utilisation de la méthode proposée pour analyser les marchés du travail en transition

Natalia Kyui

Kyui Natalia. Natalia Kyui. In: Diplômées, n°238, 2011. Femmes diplômées de l’enseignement supérieur et temps partiel. pp. 164-167

Radiation-Mediated Tumor Growth Inhibition Is Significantly Enhanced with Redox-Active Compounds That Cycle with Ascorbate

Aims: We aim here to demonstrate that radiation (RT) enhances tumor sensitization by only those Mn complexes that are redox active and cycle with ascorbate (Asc), thereby producing H2O2 and utilizing it subsequently in protein S-glutathionylation in a glutathione peroxidase (GPx)-like manner. In turn, such compounds affect cellular redox environment, described by glutathione disulfide (GSSG)/glutathione (GSH) ratio, and tumor growth. To achieve our goal, we tested several Mn complexes of different chemical and physical properties in cellular and animal flank models of 4T1 breast cancer cell. Four other cancer cell lines were used to substantiate key findings. Results: Joint administration of cationic Mn porphyrin (MnP)-based redox active compounds, MnTE-2-PyP5+ or MnTnBuOE-2-PyP5+ with RT and Asc contributes to high H2O2 production in cancer cells and tumor, which along with high MnP accumulation in cancer cells and tumor induces the largest suppression of cell viability and tumor growth, while increasing GSSG/GSH ratio and levels of total S-glutathionylated proteins. Redox-inert MnP, MnTBAP3- and two other different types of redox-active Mn complexes (EUK-8 and M40403) were neither efficacious in the cellular nor in the animal model. Such outcome is in accordance with their inability to catalyze Asc oxidation and mimic GPx. Innovation: We provided here the first evidence how structure-activity relationship between the catalytic potency and the redox properties of Mn complexes controls their ability to impact cellular redox environment and thus enhance the radiation and ascorbate-mediated tumor suppression. Conclusions: The interplay between the accumulation of cationic MnPs and their potency as catalysts for oxidation of Asc, protein cysteines, and GSH controls the magnitude of their anticancer therapeutic effects

Anticancer therapeutic potential of Mn porphyrin/ascorbate system

Ascorbate (Asc) as a single agent suppressed growth of several tumor cell lines in a mouse model. It has been tested in a Phase I Clinical Trial on pancreatic cancer patients where it exhibited no toxicity to normal tissue yet was of only marginal efficacy. The mechanism of its anticancer effect was attributed to the production of tumoricidal hydrogen peroxide (H2O2) during ascorbate oxidation catalyzed by endogenous metalloproteins. The amount of H2O2 could be maximized with exogenous catalyst that has optimized properties for such function and is localized within tumor. Herein we studied 14 Mn porphyrins (MnPs) which differ vastly with regards to their redox properties, charge, size/bulkiness and lipophilicity. Such properties affect the in vitro and in vivo ability of MnPs (i) to catalyze ascorbate oxidation resulting in the production of H2O2; (ii) to subsequently employ H2O2 in the catalysis of signaling proteins oxidations affecting cellular survival pathways; and (iii) to accumulate at site(s) of interest. The metal-centered reduction potential of MnPs studied, E1/2 of MnIIIP/MnIIP redox couple, ranged from -200 to +350 mV vs NHE. Anionic and cationic, hydrophilic and lipophilic as well as short- and long-chained and bulky compounds were explored. Their ability to catalyze ascorbate oxidation, and in turn cytotoxic H2O2 production, was explored via spectrophotometric and electrochemical means. Bell-shape structure-activity relationship (SAR) was found between the initial rate for the catalysis of ascorbate oxidation, vo(Asc)ox and E1/2, identifying cationic Mn(III) N-substituted pyridylporphyrins with E1/2\u3e0 mV vs NHE as efficient catalysts for ascorbate oxidation. The anticancer potential of MnPs/Asc system was subsequently tested in cellular (human MCF-7, MDA-MB-231 and mouse 4T1) and animal models of breast cancer. At the concentrations where ascorbate (1 mM) and MnPs (1 or 5 μM) alone did not trigger any alteration in cell viability, combined treatment suppressed cell viability up to 95%. No toxicity was observed with normal human breast epithelial HBL-100 cells. Bell-shape relationship, essentially identical to vo(Asc)ox vs E1/2, was also demonstrated between MnP/Asc-controlled cytotoxicity and E1/2-controlled vo(Asc)ox. Magnetic resonance imaging studies were conducted to explore the impact of ascorbate on T1-relaxivity. The impact of MnP/Asc on intracellular thiols and on GSH/GSSG and Cys/CySS ratios in 4T1 cells was assessed and cellular reduction potentials were calculated. The data indicate a significant increase in cellular oxidative stress induced by MnP/Asc. Based on vo(Asc)ox vs E1/2 relationships and cellular toxicity, MnTE-2-PyP5+ was identified as the best catalyst among MnPs studied. Asc and MnTE-2-PyP5+ were thus tested in a 4T1 mammary mouse flank tumor model. The combination of ascorbate (4 g/kg) and MnTE-2-PyP5+ (0.2 mg/kg) showed significant suppression of tumor growth relative to either MnTE-2-PyP5+ or ascorbate alone. About 7-fold higher accumulation of MnTE-2-PyP5+ in tumor vs normal tissue was found to contribute largely to the anticancer effect