Comparison of drug release from liquid crystalline monoolein dispersions and solid lipid nanoparticles using a flow cytometric technique

AbstractColloidal lipid particles such as solid lipid nanoparticles and liquid crystalline nanoparticles have great opportunities as drug carriers especially for lipophilic drugs intended for intravenous administration. In order to evaluate drug release from these nanoparticles and determine their behavior after administration, emulsion droplets were used as a lipophilic compartment to which the transfer of a model drug was measured. The detection of the model drug transferred from monoolein cubic particles and trimyristin solid lipid nanoparticles into emulsion droplets was performed using a flow cytometric technique. A higher rate and amount of porphyrin transfer from the solid lipid nanoparticles compared to the monoolein cubic particles was observed. This difference might be attributed to the formation of a highly ordered particle which leads to the expulsion of drug to the surface of the crystalline particle. Furthermore, the sponge-like structure of the monoolein cubic particles decreases the rate and amount of drug transferred. In conclusion, the flow cytometric technique is a suitable technique to study drug transfer from these carriers to large lipophilic acceptors. Monoolein cubic particles with their unique structure can be used successfully as a drug carrier with slow drug release compared with trimyristin nanoparticles

A Cyclic Universe With Varying Cosmological Constant in f(R,T)f(R,T) gravity

A new kind of evolution for cyclic models in which the Hubble parameter oscillates and keeps positive has been explored in a specific $f(R,T)$ gravity reconstruction. A singularity-free cyclic universe with negative varying cosmological constant has been obtained which supports the role suggested for negative $\Lambda$ in stopping the eternal acceleration. The cosmological solutions have been obtained for the case of a flat universe, supported by observations. The cosmic pressure grows without singular values, it is positive during the early-time decelerated expansion and negative during the late-time accelerating epoch. The time varying EoS parameter $\omega(t)$ shows a quintom behavior and is restricted to the range $-2.25 \leq \omega(t) \lesssim \frac{1}{3}$. The validity of the classical linear energy conditions and the sound speed causality condition has been studied. The non-conventional mechanism of negative cosmological constant that are expected to address the late-time acceleration has been discussed.Comment: 15 pages, 10 figure

THE TWO SCOPES OF FUZZY PROBABILITY THEORY

The aim of this work is to compare between what seems to be entirely different two highly developing “fuzzy probability” theories. The first theory had been developed firstly by statisticians and the other separately by physicists. We start by indicating the needs to develop such theories and what helped to develop each, then we will establish the basis of the two theories and illustrate that each indeed extends classical probability theory. Moreover, we will try to see whether or not any of the two theory can be embedded into the other

Bleeding diathesis due to vitamin K deficiency in an infant with cystic fibrosis

AbstractWith the wide implementation of newborn screening for Cystic Fibrosis, infants are being diagnosed in the presymptomatic phase of the disease. Nutritional deficiencies (hypoalbuminemia) and fat soluble vitamins A, D and E deficiencies, due to pancreatic insufficiency and malabsorption, have been reported in the past at the time of diagnosis.1,2 Rarely, infants with CF present with severe bleeding disorder, secondary to vitamin K deficiency, in the first months of life.3 To our knowledge, this is the first case report illustrating bleeding diathesis in a one month old infant with CF. He was diagnosed by newborn screening and presented with a gastrointestinal bleeding due to vitamin K deficient coagulopathy

Overcoming barriers to a successful transition from pediatric to adult care

As life expectancy for people with cystic fibrosis (CF) has increased dramatically, so has the need for a guided, structured transition from pediatric to adult-focused care. A formalized transition program allows for seamless transfer of patients between providers, helping to ensure continuity of care, and avoid potential declines associated with inconsistent medical care. New CF Center guidelines issued by the CFF strongly recommend that each center establish a transition program for age-appropriate transition to an adult CF clinic. In this article, we explore the remaining barriers to establishing a transition program in a CF Center and offer examples of several successful models. We describe CFF-sponsored and other initiatives that exist to support centers in establishing a transition program and discuss the need for ongoing research in this area

Cathodoluminescence investigations of GaAs thin layers

AbstractIn this work, we report the theoretical results of cathodoluminescence (CL) for GaAs layer. The simulation of the CL excitation and intensity is developed using 2-D model based on the electron beam energy dissipation and taking into account the effects of carrier diffusion, internal absorption and the recombination process in the semiconductors.We have investigated the influence of the electron beam conditions (energy, current and beam diameter) and some physical parameters (absorption coefficient, gap energy) on the CL intensity. Results allow us particularly to predict the intensity evolution and shift of CL peak emitted near the fundamental energy gap as a function of the electron beam current and energy. A comparative study between simulated and experimental CL spectra at low temperature is realized

The impact of conventional and nonconventional inhalants on children and adolescents

AimInhalant abuse in the adolescent population is a growing concern for care givers, communities, physicians, and medical providers. The aim of this article is to provide a review of the literature about this new challenge. In addition, it raises awareness about recent health policy rulings.MethodsReview of the literature was done.ResultsIn this review article, the prevalence of different modes of inhalant use and abuse in children and young adults and their potential health implications will be examined: Cigarettes, ENDS (E Cigarettes), Hookah, Marijuana, and Huffing. Additionally, marketing and advertising tactics will be reviewed to understand how they target this population. A review of current health policy recommendations from the FDA, American Thoracic Society, and the American Academy of Pediatrics will also be discussed.ConclusionThe rapid rise in e‐cigarette and hookah use in school aged children should trigger a call to action in the medical and public health communities. Health policy recommendations need to be made to reduce the level of adolescent substance abuse.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/142898/1/ppul23836_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/142898/2/ppul23836.pd