Comparison of Clinical and Radiographic Results of Single Tooth Implants against Endodontic Treatment with Post and Crown Repair

The choice between the two modes of treatment, endodontic treatment and single tooth implants are very different depending on the dentist, design, definition of successful outcomes, evaluation methods, and sample size. The aim of this study was to compare the clinical and radiographic results of single tooth implants versus endodontic treatment with post and crown restoration in patients referred to the School of Dentistry of Islamic Azad University of Isfahan.Materials & Methods:In this cross-sectional analytical study in the academicyear 2021, 90 (46 females and 44 males) patients after recording demographic information and medical status, during three different time intervals post treatment (under 3 years, 3 to 5 years and Over 5 years) were examined clinically and radiographically (periapical). Outcome of treatment was classified based on clinical and radiographic findings into three categories: successful, surviving and unsuccessful. Data were analyzed using Chi-squared test (α = 0.05).Results:In this study, 60% of women and 40%of men had endodontic treatment and 42.2% of women and 57.8% of men had single tooth implants. There was no significant difference between the treatment outcomes in the studied groups (p value > 0.521). There was no statistically significant relationship between gender and type of treatment as well as gender and treatment satisfaction (p value > 0.05).Conclusion:Considering the preservation of natural teeth, if possible, root canal treatment is the main treatment of choice, otherwise a single-tooth implant can be a good alternative to missing or extracted teeth in terms of successful outcome

Modeling of extracellular polymeric substances production at different Carbon/Nitrogen ratio and solid retention time by artificial neural network

Aims: The ability of extracellular polymeric substances (EPS) production was observed in many species of heterotrophic microorganisms through the biological wastewater treatment systems. Materials and Methods: The batch experiments at different carbon/nitrogen and solid retention time (SRT) were carried out to investigate the effects of initial nitrogen concentration and SRT on EPS production and chemical oxygen demand (COD) removal efficiency. The artificial neural network (ANN) was developed to modeling of obtained data. Results: The results showed that: (i) with increasing SRT, the COD removal improves; (ii) initially, the amount of carbohydrate increases as SRT increases; however, with further increase of SRT, it declines; (iii) the protein/carbohydrate ratio improves as SRT decreases; (iv) the carbohydrate and protein concentration of soluble EPS increased with increasing initial nitrogen concentration from 0 to 10 mg/L; and (v) further increase of initial nitrogen concentration lead to depletion of carbohydrate production. Conclusion: The highest yield (Y) value was calculated at low sludge age and deficient initial nitrogen concentration, which may be due to the application of EPS production mechanism. The ANN model moderately predicted effluent COD concentration, carbohydrate, and protein production

The Perspective of Therapeutic Antibody Marketing in Iran: Trend and Estimation by 2025

Background. Monoclonal antibodies with high efficiency and specificity are one of the best strategies to diagnose and treat a variety of diseases such as cancer, autoimmunity, and inflammatory diseases. The market for monoclonal therapeutic antibodies (MTAs) has grown dramatically in the past decade. Objective. Given the importance of these issues, developing countries spend a high cost on importing or producing MTAs annually. This study intends to examine the market of monoclonal therapeutic antibodies in Iran and predict the future growth rate of this market using the obtained data. Methods. Data on the status of MTAs in the country (from 2008 to 2018) were obtained from the Food and Drug Deputy of Mazandaran University of Medical Sciences. The market status of MTAs was studied based on the dosage forms, application, and price. Then, the market outlook was predicted up to year 2025. Results. The results showed that 58.8% of all MTAs were humanized, and 86% of all antibody-based drugs were used to treat cancer. Sales of MTA-based medications will reach $454 million by 2025 and are projected to grow significantly in the future. Conclusion. Given the increasing technology of the production of MTAs and their use in targeted therapies worldwide, their consumption market in Iran is expected to grow significantly

Relationship of Urinary Phthalate Metabolites with Cardiometabolic Risk Factors and Oxidative Stress Markers in Children and Adolescents

Introduction. Studies have proved that exposure of adults to phthalates might be related to cardiometabolic risk factors and changes in markers of oxidative stress. Such studies conducted on school-age children and adolescents are limited and fail to assess the simultaneous effect of phthalates on these risk factors and oxidative stress markers. Therefore, it was attempted to identify the relationship of urinary phthalate metabolites with cardiometabolic risk factors and oxidative stress markers in children and adolescents. Methods. In this cross-sectional study, 108 children and adolescents, living in Isfahan industrial city of Iran, were examined. Urine samples taken from the participants were analyzed for mono-butyl phthalate (MBP), mono-benzyl phthalate (MBzP), mono-(2-ethylhexyl) phthalate (MEHP), mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), mono-(2-ethyl-5-exohexyl) phthalate (MEOHP), and mono-methyl phthalate (MMP). Results. Results showed that, among phthalate metabolites, MBP had the highest concentration, followed by MBzP, MEOHP, MEHHP, MEHP, and MMP. Concentrations of these metabolites had a significant relationship with some of the cardiometabolic risk factors including systolic blood pressure (SBP), fasting blood sugar (FBS), and triglycerides (TG) (p < 0.05). Furthermore, the crude and adjusted linear regression models indicated the significant association of phthalate metabolites with superoxide dismutase (SOD), malondialdehyde (MDA), and homeostasis model assessment of insulin resistance (HOMA-IR) (p < 0.05). Conclusion. Although urinary phthalate concentrations could not exactly reflect the long-term exposure level in the studied age groups, the consumption of phthalate-free products during childhood and adolescent development shall be assumed helpful in maintaining a healthy lifestyle. To confirm these findings and develop effective intervention strategies, it would be necessary to perform longitudinal studies on diverse population

Investigation of prevalence of Shigella sonnei in children with diarrhea admitted to two hospital Emam Khomeini and Milad in Tehran in 1391 with Antimicrobial susceptibility of isolates

Background and Aim: Shigella infection is one of the prevalent causes of diarrhea disease in most developing countries in children under 10 years old. Conventional microbiological examination to identify Shigella species are time-consuming and requires a lot of work and cost. The object of the present research was to isolate and identify of serotypes of Shigella, Shigella sonnei from patients with bacillary dysentery and to detect their one major virulence genes ipaH by using PCR. Materials and Methods: 3000 stool sample from children with diarrhea admitted in two famous hospitals in1391 in summer & autumn in Tehran were used in this study. The identification of isolated was done by serogrouping and biochemical test & the prevalence of ipaH gene determined by PCR method using specific pairs of primers. Antimicrobial susceptibility of isolates was performed according to the CLSI guidelines. Results: All Shigella spp isolates in this study harbored the ipaH gene. Out of 160 shigella isolates, 50 isolates determined as S. sonnei with serogrouping and biochemical test. 90% of isolates were resistant to Tetracycline, Cotrimoxazole, Streptomycin and Minocycline. Conclusions: We conclude that ipaH PCR procedure is more reliable, sensitive, easier, reproducible and specific which is significantly faster than current conventional detection assays such as serologic test. Althuogh in this study we report that among Shigella .spp cause diarrhea infection most of them are S .sonnei resistant antibiotic

Removal of BPA from Aqueous Solutions by Electrocoagulation Using iron Electrodes and Optimization

&nbsp; Background and Objectives: Bisphenol A (BPA) is one of the toxic environmental pollutants that can be entered into aquatic ecosystems by raw wastewaters. In the current study, electrocoagulation used in the treatment of water and wastewater in a wide range was investigated for the removal of BPA. Materials and Methods: All the experiments were conducted in a batch system. The effect of operating parameters such as pH, BPA concentration, electrolyte concentration, distance between electrodes, current intensity, and reaction time were evaluated. Experiments were carried out at laboratory temperature (25 &deg;C), potential difference 30 V. Results: According to the results, the optimal condition were follows: BPA concentration 10 mg/L, current intensity 1500 mA, pH=7, and distance between electrodes 0.5 cm. The removal efficiency was ranged 60 to 90 percent. Conclusion: It can be concluded that the electrocoagulation process using iron electrodes in the optimal condition can acceptably remove BPA from aqueous solutions. &nbsp

The relationship between perchlorate in drinking water and cord blood thyroid hormones: First experience from Iran

Background: Considering the controversial information regarding the effects of perchlorate on thyroid function of high risk population as neonates, and given the high prevalence rate of thyroid disorders specially congenital hypothyroidism in our region, this study aims to investigate for the first time in Iran, the relationship between drinking groundwater perchlorate and cord blood thyroid hormones level in an industrial region. Methods: In this cross-sectional study, drinking groundwater perchlorate level of rural areas of Zarinshahr, Isfahan was measured. Simultaneously, cord blood level of thyroid hormones of neonates born in the studied region was measured. Thyroid function test of neonates in regions with low and high perchlorate level were compared. Results: In this study, 25 tap water samples were obtained for perchlorate measurement. Level of cord blood thyroid stimulating hormone (TSH), T4 and T3 of 25 neonates were measured. Mean (standard deviation) of perchlorate, TSH, T4 and T3 was 3.59 (5.10) μg/l, 7.81 (4.14) mIU/m, 6.06 (0.85) mg/dl, and 63.46 (17.53) mg/dl, respectively. Mean levels of thyroid function tests were not different in low ( 0.05). Conclusions: Perchlorate did not appear to be related to thyroid function of neonates in the studied industrial region. It seems that iodine status of the regions, as well as other environmental contaminants and genetic background, could impact on its relation with thyroid function of neonates