The Role of Public Health in the Fight Against Cancer: Awareness, Prevention, and Early Detection

Cancer, as a complex and devastating sickness, poses a great public health challenge on a global scale. Its far-attaining impact necessitates a devoted branch of medicine referred to as oncology, which makes a specialty in the prevention, diagnosis, and treatment of cancer. In this paper, we aim to offer a complete evaluation of the oncology sector, delving into its rich history, numerous forms of most cancers, diagnostic methods, and treatment alternatives. By exploring recent advances in oncology, which include precision remedy, immunotherapy, and the integration of era, we shed mild on the promising traits of the subject. However, it is miles essential to know the continual challenges that we face, such as the high costs related to remedy and the emergence of drug resistance. Despite these challenges, the final goal of oncology remains unwavering - to provide exceptional feasible outcomes for sufferers of most cancers, using both healing and palliative remedy strategies. As our knowledge of this complicated ailment continues to adapt, we must prioritize prevention and early detection and deal with disparities in access to care. By fostering collaboration and operating collectively, we can seriously improve the lives of tens of millions of individuals affected by cancer around the arena

Managing Biotechnology and Healthcare Innovation Challenges and Opportunities for Startups and Small Companies

The biotechnology industry poses challenges and possibilities for startups and small businesses. It is characterized by high charges and complex policies, making it difficult for such agencies to set up themselves. However, it additionally offers avenues for innovation and increase. This paper delves into powerful techniques that can be a resource in managing biotechnology innovation, which includes partnerships, highbrow assets improvement, virtual technologies, customer engagement, and government investment. These strategies are important for fulfillment in an industry that is constantly evolving. By embracing agility and area of interest focus, startups and small companies can successfully compete in this dynamic discipline

Left Ventricular Hypertrophy in Fabry's Disease in an Old Male Patient

Fabry disease is an X-linked disorder due to deficiency of the lysosomal hydrolasea-galactosidase A and the resultant accumulation of glycosphingolipids throughout the body, such as in the heart. Cardiac manifestations in Fabry disease are due to glycosphingolipid deposition in the myocardium, valves, and conduction system. Fabry cardiomyopathy, characterized by progressive severe concentric left ventricular hypertrophy. We, as a result of this, have reported a case of Fabry disease with left ventricular hypertrophy. He was admitted with dyspnea and also dizziness, general weakness, and acroparesthesias. Physical examination showed Angiokeratoma on the skin. The electrocardiography revealed ST-segment depression in leads V3–V6, and changes related to left ventricular hypertrophy. Echocardiography showed concentric left ventricular hypertrophy

Evaluation of economic value added as an effective tool to run the value-oriented management system

Shareholders always seek criteria based on which they could evaluate company's performance in order to value creation. A suitable criterion to evaluate performance should be related to shareholders on one hand and their ability to determine the value created for them on the other hand. Achieving such a criterion together with growth in management system is introduced based on value. There are several tools to run value added management system among which economic value added and market value added can be mentioned. Economic value added is a suggested value to evaluate performance of the commercial unit and an indicator for creating value derived from performance. Value added more than any other criteria is related to the real financial benefit and is considered as the best criteria to create shareholders' value

Advances in the modeling and dynamic simulation of reeving systems using the arbitrary Lagrangian–Eulerian modal method

This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.This paper presents new advances in the arbitrary Lagrangian–Eulerian modal method (ALEM) recently developed for the systematic simulation of the dynamics of general reeving systems. These advances are related to a more convenient model of the sheaves dynamics and the use of axial deformation modes to account for non-constant axial forces within the finite elements. Regarding the sheaves dynamics, the original formulation uses kinematic constraints to account for the torque transmission at the sheaves by neglecting the rotary inertia. One of the advances described in this paper is the use of the rotation angles of the sheaves as generalized coordinates together with the rope-to-sheave no-slip assumption as linear constraint equations. This modeling option guarantees the exact torque balance at the sheave without including any nonlinear kinematic constraint. Numerical results show the influence in the system dynamics of the sheave rotary inertia. Regarding the axial forces within the finite elements, the original formulation uses a combination of absolute position coordinates and transverse local modal coordinates to account for the rope absolute position and deformation shape. The axial force, which only depends on the absolute position coordinates, is constant along the element because linear shape functions are assumed to describe the axial displacements. For reeving systems with very long rope spans, as the elevators of high buildings, the constant axial force is inaccurate because the weight of the ropes becomes important and the axial force varies approximately linearly within the rope free span. To account for space-varying axial forces, this paper also introduces modal coordinates in the axial direction. Numerical results show that a set of three modal coordinates in the axial direction is enough to simulate linearly varying axial forces.Unión Europea - Horizon 2020 Marie Skłodowska-Curie No 860124, THREAD

The relationship between earning accrual component and earning cash component with return and dividend

Accounting and financial reporting as an information system is responsible for satisfying informational needs for users of financial reports, especially shareholders and credit holders. Thus, the most important goal of accounting in the view of users is to provide and to offer useful information for user decision making. Power of offering useful information to facilitate their decision making procedure in the light of future situation is known as accounting information predictability. Since accounting takes into account needs of information users, it is important to offer accounting earnings for measuring and estimating firm performance and fare casting profitability and operational cash flows. Therefore, understanding the role and features of the accounting earnings and its components to fare cast firm future profitability is one of the major subjects in the accounting theory and accounting research literature. Different queries from financial investors and analysts have shown that , even though to analyst cash flows Indicating information content of earning accruals and earning cash flows to forecast return and dividend. Profitability information has preference over cash flows. In this research, the relation between an earning accrual component and earning cash component with return and dividend was studied. To test the hypothesis, 96 firms as sample were chosen. To test hypothesis 1, first we calculated variations in the accruals independent variable (ACC) and operational cash flows (CFO). Next, we have calculated return dependent variable (RET). Also, to test hypothesis 2, using accruals independent variable (ACC) and operational cash flows (CFO), we investigated the relation between operational cash flows (CFO) and accruals and we calculated dividends dependent variable (DIV) .The research results show that there is a direct and meaningful relation between earning accruals and earning cash flows and return. Also, there is a direct and meaningful relation between earning accruals and earning cash flows and dividend. These finding have concluded that even though we cannot rely on accruals and cash flows to forecast next period earning, we can forecast return and dividend of next period with accruals and cash flows

Dynamic simulation of reeving systems with the extension of the modal approach in the axial direction

Proceedings of the ASME 2021 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. Volume 9: 17th International Conference on Multibody Systems, Nonlinear Dynamics, and Control (MSNDC). Virtual, Online. August 17–19, 2021. V009T09A015. ASME.In this work, the simulation of reeving systems has been studied by including axial modes using the Arbitrary Lagrangian-Eulerian (ALE) description. The reeving system is considered as a deformable multibody system in which the rigid bodies are connected by the elastic wire ropes through sheaves and reels. A set of absolute nodal coordinates and modal coordinates is employed to describe the motion and deformation in the axial direction. This new method allows the analysis of elements with non-constant axial strain along its length. In addition, modal coordinates are employed to describe the dynamic motion in the transverse direction. The non-constant axial displacement within the wire rope is computed in terms of the absolute position coordinates, longitudinal material coordinates, and modal deformation coordinates. To derive the governing equations of motion, Lagrange's equation is employed. The formulation is validated for a simple pendulum-like motion actuated by an initial velocity. The simulation results are provided to trace the movements of the payload. It can be seen that by adding modal coordinates, the axial force within the element changes. Moreover, the effects of modal coordinates in the axial direction are presented for a different number of nodes, and the resulting axial forces are compared with reference solution.Unión Europea - Horizon 2020 Marie Skłodowska-Curie project No. 860124 (THREAD