Cardamonin Attenuates Experimental Colitis and Associated Colorectal Cancer

Cardamonin is a naturally occurring chalcone, majorly from the Zingiberaceae family, which includes a wide range of spices from India. Herein, we investigated the anti-inflammatory property of cardamonin using different in vitro and in vivo systems. In RAW 264.7 cells, treatment with cardamonin showed a reduced nitrous oxide production without affecting the cell viability and decreased the expression of iNOS, TNF-α, and IL-6, and inhibited NF-kB signaling which emphasizes the role of cardamonin as an anti-inflammatory molecule. In a mouse model of dextran sodium sulfate (DSS)-induced colitis, cardamonin treatment protected the mice from colitis. Subsequently, we evaluated the therapeutic potential of this chalcone in a colitis-associated colon cancer model. We performed microRNA profiling in the different groups and observed that cardamonin modulates miRNA expression, thereby inhibiting tumor formation. Together, our findings indicate that cardamonin has the potential to be considered for future therapy against colorectal cancer

Proceedings of International Web Conference in Civil Engineering for a Sustainable Planet

This proceeding contains articles of the various research ideas of the academic community and practitioners accepted at the "International Web Conference in Civil Engineering for a Sustainable Planet (ICCESP 2021)". ICCESP 2021 is being Organized by the Habilete Learning Solutions, Kollam in Collaboration with American Society of Civil Engineers (ASCE), TKM College of Engineering, Kollam, and Baselios Mathews II College of Engineering, Kollam, Kerala, India. Conference Title: International Web Conference in Civil Engineering for a Sustainable PlanetConference Acronym: ICCESP 2021Conference Date: 05–06 March 2021Conference Location: Online (Virtual Mode)Conference Organizer: Habilete Learning Solutions, Kollam, Kerala, IndiaCollaborators: American Society of Civil Engineers (ASCE), TKM College of Engineering, Kollam, and Baselios Mathews II College of Engineering, Kollam, Kerala, India

Proceedings of the 2nd International Conference on Modern Trends in Engineering Technology and Management

This proceeding contains articles on the various ideas of the academic community presented at The 2nd International Conference on Modern Trends in Engineering Technology and Management (ICMEM 2023) organized by the Sree Narayana Institute of Technology Adoor-691554, Kerala, India on 4th-6th May 2023.  ICMEM 2023 aimed to provide a forum for the exchange of ideas, issues, challenges, discoveries, opportunities, and applications of Modern Trends in Engineering Technology and Management. The ever-changing scope and rapid development of science and technology generate new problems, questions, and curiosity, necessitating the exchange of brilliant ideas and raising awareness of this vital research field in a variety of directions.  Conference Title: 2nd International Conference on Modern Trends in Engineering Technology and ManagementConference Acronyms: ICMEM 2023Conference Date: 4th-6th May 2023Conference Location: Hybrid ModeConference Organizer: SNIT Adoor, Kerala, Indi