Treatment Outcome and Mortality at One and Half Year Follow-Up of HIV Infected TB Patients Under TB Control Programme in a District of South India

There is paucity of data from India on the impact of HIV related immunosuppression in response to TB treatment and mortality among HIV infected TB patients. We assessed the TB treatment outcome and mortality in a cohort of HIV infected TB patients treated with intermittent short course chemotherapy under TB control programme in a high HIV prevalent district of south India. [aOR-4.90, CI (1.85–12.96)]. Factors associated with ‘Death’ were non initiation of ART [aOR-2.80, CI (1.15–6.81)] and CPT [aOR-3.46, CI (1.47–8.14)].Despite the treatment success of 75% the high mortality (30%) in the study group is a matter of concern and needs immediate intervention. Non initiation of ART has emerged as a high risk factor for unfavourable treatment outcome and mortality. These findings underscore the importance of expanding and improving delivery of ART services as a priority and reconsideration of the programme guidelines for ART initiation in HIV infected TB patients

Interview coverage of the study group.

<p>Interview coverage of the study group.</p

Treatment outcomes of HIV infected TB patients according to Disease classification N = 281.

<p>( ) Percentage.</p

Association of treatment related risk factors with TB treatment outcome and with survival status.

<p>aOR- Adjusted Odds Ratio, CI – Confidence Interval.</p

Univariate analysis of the treatment related factors associated with survival status (N = 281).

<p>OR - Odds Ratio, CI- Confidence interval.</p>*<p>Smear status is given only for those with pulmonary TB. Smear status not available for one patient,</p>**<p>Excludes 16 patients for whom treatment cards were not available (6 in dead and 10 in survived).</p>#<p>For 47 and 26 CD4 counts were not available in dead and survived patients respectively.</p

Socio-demographic profile of HIV infected TB patients interviewed N = 176.

*<p>includes separated (10), widowed (27).</p>**<p>For those employed (105).</p

Disease Classification and CD4 counts in HIV infected TB patients N = 281.

<p>IQR – Inter Quartile Range.</p>*<p>Six smear negative patients had milliary tuberculosis and their median CD4 count was 120. (95–124).</p>**<p>One smear status not available.</p