Hamiltonisation, measure preservation and first integrals of the multi-dimensional rubber Routh sphere

We consider the multi-dimensional generalisation of the problem of a sphere, with axi-symmetric mass distribution, that rolls without slipping or spinning over a plane. Using recent results from Garc\'ia-Naranjo (arXiv: 1805:06393) and Garc\'ia-Naranjo and Marrero (arXiv: 1812.01422), we show that the reduced equations of motion possess an invariant measure and may be represented in Hamiltonian form by Chaplygin's reducing multiplier method. We also prove a general result on the existence of first integrals for certain Hamiltonisable Chaplygin systems with internal symmetries that is used to determine conserved quantities of the problem.Comment: 23 pages, 1 figure. Submitted to the special issue of Theor. Appl. Mech. in honour of Chaplygin's 150th anniversar

Inter-rater and intra-rater agreement in causality assessment of adverse drug reactions: a comparative study of WHO-UMC versus Naranjo scale

Background: The causality assessment system proposed by the WHO collaborating centre for international drug monitoring, the Uppsala monitoring centre (WHO-UMC) and the Naranjo probability scale are the generally accepted and most widely used methods for causality assessment. Both these scales are structured, transparent, consistent, and easy to apply with distinct advantages. The PvPI recommends use of WHO-UMC scale while many clinicians prefer Naranjo scale for its simplicity. As both these scales are used very widely in practise, it is important to study the level of agreement among them, to ensure proper interpretation of the causality assessment of the drugs. Objective was to study the inter-rater and intra-rater agreement in causality assessment of adverse drug reactions between WHO-UMC and Naranjo scale.Methods: A total of 200 cases were analyzed by three raters. Each ADR reporting form was analyzed by the raters independently using both the Naranjo scale and the WHO-UMC scale. The inter-rater and Intra-rater agreement of all the three raters was analyzed using kappa statistics.Results: The most common category of causality assessment was ‘possible’ which was around 73%, while the probable, definite and unlikely accounted for 23%, 3% and 1% respectively. The inter-rater agreement for the various categories of causality assessment when using Naranjo scale ranged from “very good to excellent” (Kappa value 0.95) while the same ranged from “good to very good” when the WHO-UMC scale was used (Kappa value 0.89) while the Intra-rater agreement for the three raters ranged from good to very good. The mean time (in minutes) taken for assessing the suspected adverse drug an ADR was 8. 26±2.53 for WHO-UMC scale while it was 14.18±3.44 when Naranjo scale was used.Conclusions: Both the WHO-UMC scale and Naranjo scale are reliable and valid tools for causality assessment but the Inter-rater agreement was slightly better with Naranjo as compared to WHO-UMC scale

Helen Naranjo v. Jose L. Naranjo : Brief of Respondent

APPEAL FROM BENCH TRIAL IN SALT LAKE COUNTY DISTRICT COURT, JUDGE J. DENNIS FREDRIC

USA v. Naranjo

USDC for the Eastern District of Pennsylvani

USA v. Naranjo

USDC for the Eastern District of Pennsylvani

Top physics in ATLAS

These proceedings summarize the latest measurements on top production, top properties and searches using the ATLAS detector at the LHC. The measurements are performed on $pp$ collision data with a center of mass energy $\sqrt{s} = 7, 8$ and $13$ TeV.Comment: 17th Lomonosov Conference. 4 pages,3 figure