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Interferon alfa for chronic hepatitis B infection: Increased efficacy of prolonged treatment
Interferon alfa (IFN-a) is the primary treatment for
chronic hepatitis B. The standard duration of IFN-a therapy
is considered 16 weeks; however, the optimal treatment
length is still poorly defined. We evaluated the efficacy and
acceptability of prolonged IFN-a treatment in patients with
chronic hepatitis B. To investigate whether treatment prolongation
could enhance the rate of hepatitis B e antigen
(HBeAg) seroconversion, we conducted a prospective, controlled,
multicenter trial in wh