Clinical features and subdural lesions in childhood onset Haemophilus influenzae meningitis

It becomes difficult to treat the onset of childhood Haemophilus influenza type b( Hib) meningitis due tothe appearance of b-lactamase negative ampicilin resistance( BLNAR). We investigated the clinical featuresof Hib meningitis with subdural lesions. From January 2000 to December 2006, we experienced 8 patientswith Hib meningitis. All patients were not inoculated with Hib vaccine. Five of them were onset under 1year old. Rapid latex diagnoses were made in 5 patients, among whom 4 patients showed Hib positive. Thegenotypes were determined in 4 patients with BLNAR. Combined with cefotaxime sodium (CTX) and ampicillin(ABPC) were used in 3 patients for the initial antibiotics, panipenem/betamipron( PAPM/BP) in 2,meropenem hydrate( MEPM) in 1, MEPM + ceftriaxone sodium( CTRX) in 1, and concomitant use of dexamethasonein 7 paitents. MRI showed subdural hygroma in 4 patients and subdural abscess in 4 patients.Subdural lesions appeared on Day 1 to Day 18 from the onset. Three patients with subdural abscess haveperformed subdural taps, and 2of them with difficulties after subdural taps were necessary to do oral administrationof chloramphenicol( CP).In our report, all of the patients developed subdural lesions. The development of subdural lesions cannotbe avoided with only the conventional antibiotics and dexamethasone therapy. Our cases suggested earliersubdural taps with oral administration of CP might be to improve both the general condition and control thesubdural lesions with Hib meningitis. Moreover, we should pay attention to the preventive vaccination ofHib

MRA Diagnosis of Down Syndrome Associated with Moyamoya Syndrome Presenting Multiple Cerebral Infarctions in a 1-year-old Girl

It is known that various complications are observed in patients with Down syndrome. We report a 1-year-old girl with Down syndrome who developed moyamoya syndrome presenting multiple cerebral infarction. Her chief complaints were recurrent convulsion and weakness on the left side of the body. Brain CT and MRI demonstrated multiple abnormal signals, and the lesion was diagnosed as multiple cerebral infarction. Since obstruction of the right anterior and middle cerebral arteries was observed by MRA, the patient was diagnosed with moyamoya syndrome. Moyamoya syndrome accompanied by Down syndrome advances in the early stage, and since it often occurs with cerebral infarction, the timing of its early diagnosis by MRA and caution of cerebral infarction are important. However, no guidelines for the control of moyamoya syndrome have been established in Down syndrome. Therefore, MRA should be performed in patients in whom moyamoya disease is suspected, because no useful method for the prevention of this complication disease has established

乳幼児期の体重増加と学童期のインスリン抵抗性との関係に関する系統的・探索的解析

第3回日本DOHaD研究会学術集会　抄録集　【ポスター発表

Avaliação de técnicas de sistemas de recomendação sensíveis ao tempo em modelos de vizinhança para recomendação em sessão

Traditional works in Recommender Systems focus on making personalized recommendations of new items of interest to users of a database. However, with the growth of streamming platforms and services offered online, generating recommendations for the current user session, considering his/her context, became a big area of interest in the area. Session-Based Recommender Systems focus on recommending items to a user session. When the user has a history of interactions with the platform, previous sessions can be used to infer the users preference. Nevertheless, these platforms can also attract and regularize users by recommending items of interest to anonymous users, usually passerbies, who have only the information available of the current session to make recommendations. This work investigated the use of temporal contexts in Session-Based Recommender Systems, focusing in anonymous sessions recommendations, using neighborhoodbased models, which are among the state-of-the-art models in this task. For this to happen, we performed a deep analysis of the existing neighborhood-based models and analyzed how the application of various contexts in these algorithms influences their performance, as well as providing insights about the interactions made in a given dataset.Trabalhos tradicionais em Sistemas de Recomendação focam em trazer recomendações personalizadas de novos itens de interesse para os usuários de uma base de dados. Porém, com o crescimento de plataformas de stream e de serviços oferecidos online, produzir recomendações focadas na sessão atual do usuário, levando em conta o seu contexto, se tornou uma grande área de interesse para este setor de pesquisa. A área de Sistemas de Recomendação Baseada em Sessão foca em recomendar items para uma sessão de usuário. Quando o usuário possui um histórico na plataforma, é possível utilizar sessões anteriores para inferir suas preferências. Porém, plataformas também podem atrair e fidelizar usuários recomendando itens de interesse para usuários anônimos, muitas vezes transeuntes, sendo que o sistema possui apenas os dados adquiridos da sessão atual para fazer recomendações. Este trabalho investiga o uso de contextos temporais em Sistemas de Recomendação Baseada em Sessão, com o foco em recomendações para usuários anônimos, utilizando modelos de vizinhança, que estão entre os modelos do estado-da-arte nesta tarefa. Para isso, foi realizado um estudo aprofundado dos modelos de vizinhança existentes e como a aplicação de diversos contextos a esses algoritmos influencia o desempenho deles. Além disso, este trabalho provê também instrospecções sobre as interações realizadas em uma bases de dados

Allexiviruses may have acquired inserted sequences between the CPand CRP genes to change the translation reinitiation strategy of CRP

AbstractAllexiviruses are economically important garlic viruses that are involved in garlic mosaic diseases. In this study, we characterizedthe allexivirus cysteine-rich protein (CRP) gene located just downstream of the coat protein (CP) gene in the viralgenome. We determined the nucleotide sequences of the CP and CRP genes from numerous allexivirus isolates and performeda phylogenetic analysis. According to the resulting phylogenetic tree, we found that allexiviruses were clearly divided intotwo major groups (group I and group II) based on the sequences of the CP and CRP genes. In addition, the allexiviruses ingroup II had distinct sequences just before the CRP gene, while group I isolates did not. The inserted sequence between theCP and CRP genes was partially complementary to garlic 18S rRNA. Using a potato virus X vector, we showed that theCRPs affected viral accumulation and symptom induction in Nicotiana benthamiana, suggesting that the allexivirus CRP isa pathogenicity determinant. We assume that the inserted sequences before the CRP gene may have been generated duringviral evolution to alter the termination-reinitiation mechanism for coupled translation of CP and CRP

Controllability of luminescence wavelength from GeSn wires fabricated by laser-induced local liquid phase crystallization on quartz substrates

We examined the effects of the laser scan speed and power on the Sn fraction and crystallinity of GeSn wires of 1 μm width and 1 mm length fabricated by laser-induced local liquid phase crystallization on quartz substrates. The Sn fraction increased from 1% to 3.5% with an increasing scan speed from 5 to 100 μm s⁻¹, corresponding to a luminescence wavelength of 1770–2070 nm. This result can be interpreted as the scan speed dependence of the non-equilibrium degree during crystal growth. The increase in the laser power reduced the Sn fraction and caused a blue shift in the luminescence wavelength. We discuss these phenomena based on the growth kinetics of zone melting.This is the Accepted Manuscript version of an article accepted for publication in Japanese Journal of Applied Physics. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The Version of Record is available online at https://doi.org/10.35848/1347-4065/acb9a2