Inter-individual Variations in Circadian Misalignment-induced Nafld Pathophysiology in Mice

Pathological consequences of circadian misalignment, such as shift work, show considerable individual differences, but the lack of mechanistic understanding hinders precision prevention to prevent and mitigate disease symptoms. Here, we employed an integrative approach involving physiological, transcriptional, and histological phenotypes to examine inter-individual differences in pre-symptomatic pathological progression, preceding irreversible disease onset, in wild-type mice exposed to chronic jet-lag (CJL). We observed that CJL markedly increased the prevalence of hepatic steatosis with pronounced inter-individual differences. Stratification of individual mice based on CJL-induced hepatic transcriptomic signature, validated by histopathological analysis, pinpoints dysregulation of lipid metabolism. Moreover, the period and power of intrinsic behavioral rhythms were found to significantly correlate with CJL-induced gene signatures. Together, our results suggest circadian rhythm robustness of the animals contributes to inter-individual variations in pathogenesis of circadian misalignment-induced diseases and raise the possibility that these physiological indicators may be available for predictive hallmarks of circadian rhythm disorders

Recent Progress at KEKB

We summarize the machine operation of KEKB during past one year. Progress for this period, causes of present performance limitations and future prospects are described

The SuperKEKB Has Broken the World Record of the Luminosity

The SuperKEKB broke the world record of the luminosity in June 2020 in the Phase 3 operation. The luminosity has been increasing since then and the present highest luminosity is 4.65 x 10³⁴ cm⁻²s⁻¹ with β_{y}^{*} of 1 mm. The increase of the luminosity was brought with an application of crab waist, by increasing beam currents and by other improvements in the specific luminosity. In this paper, we describe what we have achieved and what we are struggling with. Finally, we mention a future plan briefly

Beam Commissioning of SuperKEKB

International audienceIn this report, we describe the machine operation in the first 3 months of the Phase 1 commissioning of SuperKEKB. The beam commissioning is smoothly going on. Vacuum scrubbing, the optics corrections and others are described

Achievements of KEKB

The machine commissioning of KEKB started in December 1998 and its operation was terminated at the end of June 2010 to upgrade KEKB to SuperKEKB. In this paper, we summarize the history of KEKB and show the achievements made there