VLBI Monitoring of 3C 84 (NGC 1275) in Early Phase of the 2005 Outburst

Multi-epoch Very Long Baseline Interferometry (VLBI) study of the sub-pc scale jet of 3C 84 is presented. We carried out 14-epoch VLBI observations during 2006-2009 with the Japanese VLBI Network (JVN) and the VLBI Exploration of Radio Astrometry (VERA), immediately following the radio outburst that began in 2005. We confirmed that the outburst was associated with the central ~1 pc core, accompanying the emergence of a new component. This is striking evidence of the recurrence of jet activity. The new component became brighter during 2008, in contrast to the constant gamma-ray emission that was observed with the Fermi Gamma-ray Space Telescope during the same time. We found that the projected speed of the new component is 0.23c from 2007/297 (2007 October 24) to 2009/114 (2009 April 24). The direction of movement of this component differs from that of the pre-existing component by ~40 degree. This is the first measurement of kinematics of a sub-pc jet in a gamma-ray active phase. Possible detection of jet deceleration and the jet kinematics in connection with the gamma-ray emission is discussed.Comment: 5 pages, 3 figures. Accepted for publication in PAS

Association between Serum Soluble Klotho Levels and Mortality in Chronic Hemodialysis Patients

Klotho is a single-pass transmembrane protein predominantly expressed in the kidney. The extracellular domain of Klotho is subject to ectodomain shedding and is released into the circulation as a soluble form. Soluble Klotho is also generated from alternative splicing of the Klotho gene. In mice, defects in Klotho expression lead to complex phenotypes resembling those observed in dialysis patients. However, the relationship between the level of serum soluble Klotho and overall survival in hemodialysis patients, who exhibit a state of Klotho deficiency, remains to be delineated. Here we prospectively followed a cohort of 63 patients with a mean duration of chronic hemodialysis of 6.7±5.4 years for a median of 65 months. Serum soluble Klotho was detectable in all patients (median 371 pg/mL, interquartile range 309–449). Patients with serum soluble Klotho levels below the lower quartile (<309 pg/mL) had significantly higher cardiovascular and all-cause mortality rates. Furthermore, the higher all-cause mortality persisted even after adjustment for confounders (hazard ratio 4.14, confidence interval 1.29–13.48). We conclude that there may be a threshold for the serum soluble Klotho level associated with a higher risk of mortality

A Role of Aromatase in Sjögren Syndrome

Several autoimmune diseases are known to develop in postmenopausal women. However, the mechanism by which estrogen deficiency influences autoimmunity is unknown. Aromatase is a converting enzyme from androgens to estrogens. In the present study, we used female aromatase gene knockout (ArKO) mice as a model of estrogen deficiency to investigate the molecular mechanism that underlies the onset and development of autoimmunity. Histological analyses showed that inflammatory lesions in the lacrimal and salivary glands of ArKO mice increased with age. Adoptive transfer of spleen cells or bone marrow cells from ArKO mice into recombination activating gene 2 knockout mice failed to induce the autoimmune lesions. Expression of mRNA encoding proinflammatory cytokines and monocyte chemotactic protein-1 (MCP-1) increased in white adipose tissue (WAT) of ArKO mice and was significantly higher than that in wild-type mice. Moreover, an increased number of inflammatory M-1 macrophage was observed in WAT of ArKO mice. A significantly increased MCP-1 mRNA expression of the salivary gland tissue in ArKO was found together with adiposity. Furthermore, the autoimmune lesions in a murine model of Sjögren’s syndrome (SS) were exacerbated by administration of an aromatase inhibitor. These results suggest that aromatase may play in a key role in the pathogenesis of SS-like lesions by controlling the target organ and adipose tissue-associated macrophage