1 research outputs found
Circadian clock regulates hepatic polyploidy by modulating Mkp1-Erk1/2 signaling pathway.
Circadian clock regulates hepatic gene expression and functions. Here Chao et al. show that alteration of circadian clock genes by Period deletion induces polyploidy in hepatocytes due to impaired regulation of Erk signaling by mitogen-activated protein kinase phosphatase 1