Effects of a novel elastase inhibitor, ONO-5046, on nephrotoxic serum nephritis in rats

Effects of a novel elastase inhibitor, ONO-5046, on nephrotoxic serum nephritis in rats. ONO-5046 is a potent, specific and intravenously active inhibitor of neutrophil elastase. To examine the role of elastase in glomerulonephritis, we tested the effects of ONO-5046 on nephrotoxic serum (NTS) nephritis in a rat model of the disease in humans. Rats were administered ONO-5046 or phosphate-buffered saline (PBS) intraperitoneally 24hours prior to injection of NTS, and they were then given equal doses of ONO-5046 or PBS three hours and 1, 2, 3, 4, 5 and 6days later. Compared with the control groups, ONO-5046 significantly reduced proteinuria and hematuria, and suppressed the formation of crescentic glomeruli in a dose-dependent manner. Our results suggest that neutrophil elastase participates in NTS nephritis by degrading glomerular basement membrane proteins, and that the elastase inhibitor, ONO-5046, suppresses crescentic formation and glomerular injury caused by elastase

J- and Ks-band Galaxy Counts and Color Distributions in the AKARI North Ecliptic Pole Field

We present the J- and Ks-band galaxy counts and galaxy colors covering 750 square arcminutes in the deep AKARI North Ecliptic Pole (NEP) field, using the FLoridA Multi-object Imaging Near-ir Grism Observational Spectrometer (FLAMINGOS) on the Kitt Peak National Observatory (KPNO) 2.1m telescope. The limiting magnitudes with a signal-to-noise ratio of three in the deepest regions are 21.85 and 20.15 in the J- and Ks-bands respectively in the Vega magnitude system. The J- and Ks-band galaxy counts in the AKARI NEP field are broadly in good agreement with those of other results in the literature, however we find some indication of a change in the galaxy number count slope at J~19.5 and over the magnitude range 18.0 < Ks < 19.5. We interpret this feature as a change in the dominant population at these magnitudes because we also find an associated change in the B - Ks color distribution at these magnitudes where the number of blue samples in the magnitude range 18.5 < Ks < 19.5 is significantly larger than that of Ks < 17.5

Number Density Evolution of Ks -band Selected High Redshift Galaxy Populations in the AKARI North Ecliptic Pole Field

We present the number counts of Ks-band selected high redshift galaxy populations such as extremely red objects (EROs), B, z & K -band selected galaxies (BzKs) and distant red galaxies (DRGs) in the AKARI NEP field. The final catalogue contains 308 EROs (Ks<19.0 ; 54 percent are dusty star-forming EROs and the rest are passive old EROs), 137 star-forming BzKs and 38 passive old BzKs (Ks<19.0) and 64 DRGs (Ks<18.6). We also produce individual component source counts for both the dusty star-forming and passive populations. We compare the observed number counts of the high redshift passively evolving galaxy population with a backward pure luminosity evolution (PLE) model allowing different degrees of number density evolution. We find that the PLE model without density evolution fails to explain the observed counts at faint magnitudes, while the model incorporating negative density evolution is consistent with the observed counts of the passively evolving population. We also compare our observed counts of dusty star-forming EROs with a phenomenological evolutionary model postulating that the near-infrared EROs can be explained by the source densities of the far-infrared - submillimetre populations. Our model predicts that the dusty ERO source counts can be explained assuming a 25 percent contribution of submillimetre star-forming galaxies with the majority of brighter Ks -band detected dusty EROs having luminous (rather than HR10 type ultra-luminous) submillimetre counterparts. We propose that the fainter Ks>19.5 population is dominated by the sub-millijansky submillimetre population. We also predict a turnover in in dusty ERO counts around 19<Ks<20.Comment: (37 pages, 14 figures accepted for publication in The Astrophysical Journal

The Ganymede Laser Altimeter (GALA) for the Jupiter Icy Moons Explorer (JUICE): Mission, science, and instrumentation of its receiver modules

The Jupiter Icy Moons Explorer (JUICE) is a science mission led by the European Space Agency, being developed for launch in 2023. The Ganymede Laser Altimeter (GALA) is an instrument onboard JUICE, whose main scientific goals are to understand ice tectonics based on topographic data, the subsurface structure by measuring tidal response, and small-scale roughness and albedo of the surface. In addition, from the perspective of astrobiology, it is imperative to study the subsurface ocean scientifically. The development of GALA has proceeded through an international collaboration between Germany (the lead), Japan, Switzerland, and Spain. Within this framework, the Japanese team (GALA-J) is responsible for developing three receiver modules: the Backend Optics (BEO), the Focal Plane Assembly (FPA), and the Analog Electronics Module (AEM). Like the German team, GALA-J also developed software to simulate the performance of the entire GALA system (performance model). In July 2020, the Proto-Flight Models of BEO, FPA, and AEM were delivered from Japan to Germany. This paper presents an overview of JUICE/GALA and its scientific objectives and describes the instrumentation, mainly focusing on Japan’s contribution

A study on the macroscopic self-organized structure of high-power millimeter-wave breakdown plasma

Air breakdown plasma induced by a strong electromagnetic (EM) wave field with a millimeter wavelength has a self-formed filamentary structure. The scale of the breakdown plasma is much larger than the wavelength scale, and the power density is lower than the self-ignition threshold of atmospheric breakdown. We observed a breakdown plasma that consisted of small plasma spots, and their trajectory was identical to that of the filamentary structure observed macroscopically. The numerical analysis showed that the interaction of the ionization front, EM field, and neutral-gas heating determines the self-organized structure of the branching plasma. The plasma trajectory identified in the analysis was identical to that of the experimental results. This novel physical process was entirely different from the discrete filament formation observed in the breakdown plasma formed under a focused beam, and the physical process of the breakdown strongly depended on the scale and power density

Monkeys, Apes, and HumansPrimatology in Japan /

X, 52 p. 19 illus., 10 illus. in color.online res

Pathogenic variants of Alport syndrome and monogenic diabetes identified by exome sequencing in a family

Abstract We present a family of two female Alport syndrome patients with a family history of impaired glucose tolerance. Whole exome sequencing identified a novel heterozygous variant of COL4A5 NM_033380.3: c.2636 C > A (p.S879*) and a rare variant of GCK NM_001354800.1: c.1135 G > A (p.A379T) as the causes of Alport syndrome and monogenic diabetes, respectively. Two independent pathogenic variants affected the clinical phenotypes. Clinical next-generation sequencing is helpful for identifying the causes of patients’ manifestations