Early adolescence: Crossing through the Great Divide

The exodus of young people from traditional churches is well established and this project is a handbook to guide more meaningful engagement with young adolescents. Based in ministry experience and research, the handbook addresses parents, religious educators, youth ministers, and pastors who seek to enhance young adolescents’ faith formation. By affirming and encouraging them through this time of changing bodies, minds, and emotions, early adolescent faith formation can introduce Catholic Christian beliefs and values in a context that matters to the youth: their own struggle to become the persons God created them to be. The handbook makes practical suggestions for effective ways to build inter generational relationships

What Is a Schizophrenic Mouse?

In this issue of Neuron, Clapcote et al. examine mice containing missense mutations of the DISC1 gene, a locus associated with major mental illness in at least one large Scottish family. Genetic manipulation of mouse homologs of genes implicated in the etiology of psychiatric disorders is a promising avenue of research, but also one that is fraught with interpretative difficulties

Planning Library Promotions: An Idea Workshop

Planning library promotions: An idea workshop Anyone who works with social media or marketing events and programs for their library knows that it can be hard to keep the creative juices flowing. During the course of this workshop we will: Engage in creativity boosting exercises and activities Brainstorm ideas, activities, and resources Discuss the importance of planning cross-channel promotions Learn how to spot opportunities to promote the work of other organizations and promotions from other organizations that can be shared Learn from each other’s experiences of the difficulties and triumphs of working with social media Whether you are running the one-person social media show or working with a team, this workshop will give you the tools you need to design unique and eye-catching promotions without breaking the bank or spending hours on one post

TP63-mutation as a cause of prenatal lethal multicystic dysplastic kidneys

BACKGROUND: Ectrodactyly-ectodermal dysplasia-clefting syndrome 3 (EEC) is one of the six overlapping syndromes caused by mutations in the tumor protein p63 gene (TP63). EEC is suspected when patients have cleft hands or feet, polydactyly, and syndactyly, abnormal development of the ectodermally derived structures, and orofacial clefting. Genitourinary (GU) anomalies have been identified in patients with EEC, yet these are often under-recognized and under-reported. The available literature on sonographic prenatal findings is sparse, especially when considering GU anomalies. METHODS: We present the case of a male stillborn fetus, who was found antenatally to have multicystic dysplastic kidneys and anhydramnios. Following the termination of pregnancy, examination and autopsy further revealed unilateral polydactyly and bilateral syndactyly which had not been previously identified on antenatal ultrasound. RESULTS: Whole-exome sequencing (WES) revealed a de novo heterozygous pathogenic variant in exon 5 of the TP63 gene: p.His247Arg: c.740A\u3eG (NM_003722.4) which has been reported in the literature. The His247Arg variant has been published as a pathogenic variant in association with EEC, both with and without orofacial clefting. CONCLUSION: Our prenatal case expands the phenotypic spectrum of TP63-related disorders in general. In addition, it adds to the phenotype associated with the His247Arg pathogenic variant responsible for EEC. Further, we highlight the importance of WES as a postnatal tool to help clarify unexpected findings, and as a way to add to the spectrum of existing phenotypes of known single-gene disorders

Psychiatric Disorder Criteria and their Application to Research in Different Racial Groups

BACKGROUND: The advent of standardized classification and assessment of psychiatric disorders, and considerable joint efforts among many countries has led to the reporting of international rates of psychiatric disorders, and inevitably, their comparison between different racial groups. RESULTS: In neurologic diseases with defined genetic etiologies, the same genetic cause has different phenotypes in different racial groups. CONCLUSION: We suggest that genetic differences between races mean that diagnostic criteria refined in one racial group, may not be directly and simply applicable to other racial groups and thus more effort needs to be expended on defining diseases in other groups. Cross-racial confounds (in addition to cultural confounds) make the interpretation of rates in different groups even more hazardous than seems to have been appreciated

Structural Social Work Lens: A View of Youth Engagement in the Social Policy Life of their Communities

Presented through a structural social work lens, this paper is a description and analysis of an action research project designed to explore factors that encourage or impede the engagement of youth in the social policy life of their communities. The project was conceptualized in a geographic region characterized by the erosion of community sustainability due to social economic disadvantage and out migration. The project aimed to strengthen communities by enhancing participation of youth in social policy development. It utilized a workshop designed and delivered by youth for youth and the development a Social Policy Action Plan (SPAP) to address a policy issue of concern in youth’s local community. Principles of structural social work, with particular attention to power sharing, unmasking the structures, collective consciousness, transformation of power/political and personal change, social action and community capacity building are applied as a lens to explore this project

Systemic RAGE ligands are upregulated in tuberculosis individuals with diabetes co-morbidity and modulated by anti-tuberculosis treatment and metformin therapy

BACKGROUND: Ligands of the receptor for advanced glycation end products (RAGE) are key signalling molecules in the innate immune system but their role in tuberculosis-diabetes comorbidity (TB-DM) has not been investigated. METHODS: We examined the systemic levels of soluble RAGE (sRAGE), advanced glycation end products (AGE), S100A12 and high mobility group box 1 (HMGB1) in participants with either TB-DM, TB, DM or healthy controls (HC). RESULTS: Systemic levels of AGE, sRAGE and S100A12 were significantly elevated in TB-DM and DM in comparison to TB and HC. During follow up, AGE, sRAGE and S100A12 remained significantly elevated in TB-DM compared to TB at 2nd month and 6th month of anti-TB treatment (ATT). RAGE ligands were increased in TB-DM individuals with bilateral and cavitary disease. sRAGE and S100A12 correlated with glycated hemoglobin levels. Within the TB-DM group, those with known diabetes (KDM) revealed significantly increased levels of AGE and sRAGE compared to newly diagnosed DM (NDM). KDM participants on metformin treatment exhibited significantly diminished levels of AGE and sRAGE in comparison to those on non-metformin regimens. CONCLUSIONS: Our data demonstrate that RAGE ligand levels reflect disease severity and extent in TB-DM, distinguish KDM from NDM and are modulated by metformin therapy

THE EFFECT OF COVID-19 TEST CANCELLATION ON HEALTH CARE WORKERS ' REMUNERATION

The signs of a drastic decline in Covid-19 cases will have an impact on various related businesses where healthcare workers are involved. With the end of the Covid-19 pandemic, it will automatically result in the abolition of the PCR or Antigen Test which will have an impact on the reducing of their remuneration. The purpose of this study is to analyze the impact of canceling the Covid-19 test on several types of remuneration for health workers. This study used PRISMA analysis supported by the PICOT model. The research was conducted through document search, keyword identification and article review from Google Scholar (n=41), SagePub (n=16), Pubmed (n=6), Semantic Scholar (n=4), and others (n= 31). Other documents were discarded because they were irrelevant, duplication, and other reasons that were not on topic (n=29). The results of the PRISMA analysis showedfour problems faced by health workers as a result of the reduction in Covid-19 tests for health workers, namely: a decrease in job vacancies, a reduction in functional benefits and a decrease in personal business for health workers. We recommended to the empowerment of COVID-19 health workers and increasing business potential for health workers as an effort to restore the welfare of health workers