(E)-2-[2-(4-Chloro­benzyl­idene)hydrazin­yl]-4-[3-(morpholin-4-ium-4-yl)propyl­amino]­quinazolin-1-ium bis­(perchlorate)

In the title compound, C22H27ClN6O2 2+·2ClO4 −, the mol­ecule adopts an E conformation about the C=N double bond. The quinazoline ring is approximately planar, with an r.m.s. deviation of 0.0432 Å, and forms a dihedral angle of 5.77 (4)° with the chloro­phenyl ring. The crystal packing features N—H⋯O hydrogen bonds

Anxiety, Loneliness, Drug Craving, and Depression Among Substance Abusers in Sichuan Province, China

Studies have reported that anxiety had a positive effect on depression among substance abusers in males. However, little is known about the mechanism underlying this relationship in substance abusers in males. The purpose of this study was to investigate the mediating effect of loneliness and drug craving between anxiety and depression in substance abusers in males. State-Trait Anxiety Inventory, The UCLA Loneliness Scale, Drug Craving Scale, and The Center for Epidemiologic Studies Depression Scale were employed into this study to investigate 585 substance abusers in males (age range of 20-58 years: M = 33.21, SD = 6.97). Structural equation modeling and the bootstrap approach were used to analyze the mediating effect of loneliness and drug craving on the relationship between anxiety and depression. The results indicated that: Loneliness had a significant positive correlation with anxiety (r = 0.37, p < 0.001) and depression (r = 0.49, p < 0.001);Drug craving had a significant positive correlation with anxiety (r = 0.28, p < 0.001) and depression (r = 0.39, p < 0.001). Loneliness and drug craving mediated the link between anxiety and depression. There was a significant positive correlation between substance abusers in male's anxiety, loneliness, drug craving, and depression. Loneliness and drug craving had a significant mediating effect on the relationship between anxiety and depression. Therefore, it was suggested that substance abusers in male's anxiety and depression might be improved and driven by decreasing loneliness and drug craving. Targeted interventions to decrease substance abusers in male's loneliness and drug craving should be developed, implemented, and help them to recover

Self-Efficacy and Depression in Boxers: A Mediation Model

Background: Depression has become one of the most common problems faced by athletes. In many mental health problems, its production and development mechanisms and influencing factors have received full attention from researchers, whereas boxers’ depression has received limited attention. This study explored the relationship between boxers’ self-efficacy and depression, as well as the effect of self-control as a mediating factor. Methods: This study used the athlete self-efficacy scale (ASES), the self-control scale (SCS), and the Center for Epidemiologic Studies depression scale (CES-D). Using a large number of randomly selected samples, a total of N=231 boxers (age: M =20.28, SD = 2.60, ages around 18 to 32; the total number of years of exercise: M = 6.07 years, SD = 2.90, years around 1 to 15; 144 male) of Chinese national athletes participated the study. Results: Self-efficacy and self-control were negatively correlated with depression; self-efficacy was positively correlated with self-control. In addition, self-control played a partial mediation role between self-efficacy and depression among boxers. Conclusion: Above all, an important way to improve and prevent the depression of Chinese boxers maybe enhance their level of self-efficacy and self-control