152 research outputs found
CCDC 1934607: Experimental Crystal Structure Determination
No full textRelated Article: Vitaly Kovalenko, Nikolay Tumanov, Kiryl Vasiutovich, Tom Leyssens|2020|Chem. Data Collect.|25|100339|doi:10.1016/j.cdc.2020.10033
CCDC 1854188: Experimental Crystal Structure Determination
No full textRelated Article: Stéphane Le Gac, Victoria Ndoyom, Luca Fusaro, Vincent Dorcet, Bernard Boitrel|2019|Chem.-Eur.J.|25|845|doi:10.1002/chem.20180471
INSPIRE UNamur WP10 dataset
No full textWP10 simulation dataset, prompt gamma signal from nanoparticle
CCDC 1572446: Experimental Crystal Structure Determination
No full textRelated Article: Antoine Nitelet, Johan Wouters, Damien F. Dewez, Gwilherm Evano|2017|Org.Lett.|19|6276|doi:10.1021/acs.orglett.7b02859,An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
Radiation-induced synthetic lethality: combination of poly(ADP-ribose) polymerase and RAD51 inhibitors to sensitize cells to proton irradiation
No full textAlthough improvements in radiation therapy were made over the years, radioresistance is still a major challenge. Cancer cells are often deficient for DNA repair response, a feature that is currently exploited as a new anti-cancer strategy. In this context, combination of inhibitors targeting complementary pathways is of interest to sensitize cells to radiation. In this work, we used PARP (Olaparib) and RAD51 (B02) inhibitors to radiosensitize cancer cells to proton and X-ray radiation. More particularly, Olaparib and B02 were used at concentration leading to limited cytotoxic (alone or in combination) but increasing cell death when the cells were irradiated. We showed that, although at limited concentration, Olaparib and B02 were able to radiosensitize different cancer cell lines, i.e. lung and pancreatic cancer cells. Antagonistic, additive or synergistic effects were observed and correlated to cell proliferation rate. The inhibitors enhanced persistent DNA damage, delayed apoptosis, prolonged cell cycle arrest and senescence upon irradiation. These results demonstrated that radiation-induced synthetic lethality might widen the therapeutic window, hence extending the use of PARP inhibitors to patients without BRCAness
CCDC 1903921: Experimental Crystal Structure Determination
No full textRelated Article: Gabriel M. Mercier, Koen Robeyns, Nikolay Tumanov, Benoit Champagne, Johan Wouters, Tom Leyssens|2019|Cryst.Growth Des.|19|5544|doi:10.1021/acs.cgd.9b0036
CCDC 1903908: Experimental Crystal Structure Determination
No full textRelated Article: Gabriel M. Mercier, Koen Robeyns, Nikolay Tumanov, Benoit Champagne, Johan Wouters, Tom Leyssens|2019|Cryst.Growth Des.|19|5544|doi:10.1021/acs.cgd.9b0036
CCDC 1903917: Experimental Crystal Structure Determination
No full textRelated Article: Gabriel M. Mercier, Koen Robeyns, Nikolay Tumanov, Benoit Champagne, Johan Wouters, Tom Leyssens|2019|Cryst.Growth Des.|19|5544|doi:10.1021/acs.cgd.9b0036
CCDC 1903909: Experimental Crystal Structure Determination
No full textRelated Article: Gabriel M. Mercier, Koen Robeyns, Nikolay Tumanov, Benoit Champagne, Johan Wouters, Tom Leyssens|2019|Cryst.Growth Des.|19|5544|doi:10.1021/acs.cgd.9b0036
CCDC 1917501: Experimental Crystal Structure Determination
No full textRelated Article: Vanessa K. Seiler, Nikolay Tumanov, Koen Robeyns, Benoit Champagne, Johan Wouters, Tom Leyssens|2019|Cryst.Growth Des.|20|608|doi:10.1021/acs.cgd.9b0090
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