Towards real-time metabolic profiling of a biopsy specimen during a surgical operation by 1H high resolution magic angle spinning nuclear magnetic resonance: a case report

<p>Abstract</p> <p>Introduction</p> <p>Providing information on cancerous tissue samples during a surgical operation can help surgeons delineate the limits of a tumoral invasion more reliably. Here, we describe the use of metabolic profiling of a colon biopsy specimen by high resolution magic angle spinning nuclear magnetic resonance spectroscopy to evaluate tumoral invasion during a simulated surgical operation.</p> <p>Case presentation</p> <p>Biopsy specimens (n = 9) originating from the excised right colon of a 66-year-old Caucasian women with an adenocarcinoma were automatically analyzed using a previously built statistical model.</p> <p>Conclusions</p> <p>Metabolic profiling results were in full agreement with those of a histopathological analysis. The time-response of the technique is sufficiently fast for it to be used effectively during a real operation (17 min/sample). Metabolic profiling has the potential to become a method to rapidly characterize cancerous biopsies in the operation theater.</p

Troubles neuropsychiatriques dans les accidents ischémiques constitués du territoire de l'artère choroïdienne antérieure (corrélation anatomiques et fonctionnelles.)

STRASBOURG-Medecine (674822101) / SudocSudocFranceF