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Multi-Nozzle Biopolymer Deposition for Freeform Fabrication of Tissue Constructs
Advanced freeform fabrication techniques have been recently used for the construction of tissue
scaffolds because of the process repeatability and capability of high accuracy in fabrication
resolution at the macro and micro scales. Among many applicable tissue scaffolding materials,
polymeric materials have unique properties in terms of the biocompatibility and degradation, and
have thus been widely utilized in tissue engineering applications. Hydrogels, such as alginate,
has been one of the most important polymer scaffolding materials because of its biocompatibility
and internal structure similarity to that of the extracellular matrix of many tissues, and its
relatively moderate processing. Three-dimensional deposition has been an entreating freeform
fabrication method of biopolymer and particularly hydrogel scaffolds because of its readiness to
deposit fluids at ambient temperatures. This paper presents a recent development of biopolymer
deposition based freeform fabrication for 3-diemnsinal tissue scaffolds. The system
configuration of multi-nozzles used in the deposition of sodium alginate solutions and Poly-?-
Caprolactone (PCL) are described. Studies on polymer deposition feasibility and structural
formability are conducted, and the preliminary results are presented.Mechanical Engineerin
Helices at Interfaces
Helically coiled filaments are a frequent motif in nature. In situations
commonly encountered in experiments coiled helices are squeezed flat onto two
dimensional surfaces. Under such 2-D confinement helices form "squeelices" -
peculiar squeezed conformations often resembling looped waves, spirals or
circles. Using theory and Monte-Carlo simulations we illuminate here the
mechanics and the unusual statistical mechanics of confined helices and show
that their fluctuations can be understood in terms of moving and interacting
discrete particle-like entities - the "twist-kinks". We show that confined
filaments can thermally switch between discrete topological twist quantized
states, with some of the states exhibiting dramatically enhanced
circularization probability while others displaying surprising
hyperflexibility
Free Energy Approach to the Formation of an Icosahedral Structure during the Freezing of Gold Nanoclusters
The freezing of metal nanoclusters such as gold, silver, and copper exhibits
a novel structural evolution. The formation of the icosahedral (Ih) structure
is dominant despite its energetic metastability. This important phenomenon,
hitherto not understood, is studied by calculating free energies of gold
nanoclusters. The structural transition barriers have been determined by using
the umbrella sampling technique combined with molecular dynamics simulations.
Our calculations show that the formation of Ih gold nanoclusters is attributed
to the lower free energy barrier from the liquid to the Ih phases compared to
the barrier from the liquid to the face-centered-cubic crystal phases
Propagation of Exchange Bias in CoFe/FeMn/CoFe Trilayers
CoFe/FeMn, FeMn/CoFe bilayers and CoFe/FeMn/CoFe trilayers were grown in
magnetic field and at room temperature. The exchange bias field
depends strongly on the order of depositions and is much higher at CoFe/FeMn
than at FeMn/CoFe interfaces. By combining the two bilayer structures into
symmetric CoFe/FeMn()/CoFe trilayers, and
of the top and bottom CoFe layers, respectively, are both enhanced.
Reducing of the trilayers also results in enhancements of
both and . These results evidence the propagation of
exchange bias between the two CoFe/FeMn and FeMn/CoFe interfaces mediated by
the FeMn antiferromagnetic order
Kinesthetic Language Learning: How an Accident Led to a Revelation
This essay analyzes a critical incident that took place in a hybrid distancelearning Hebrew language class that was adapting interactive, immersion-style, kinesthetic pedagogy during the week-long face-to-face intensive portion of the class – including Total Physical Response techniques in which students respond to the language with whole-body actions, entering into the world created by the language and the particular biblical text. Memorization, performance, interactive games, songs, and skits also contribute to the immersion-style learning environment. A snafu on the final day of the week led to a serendipitous solution that demonstrated Parker Palmer’s idea of subject centered pedagogy. A brief description and analysis of the critical incident is followed by two short responses
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