Correlation of Creatinine Clearance Calculated by Cockcroft & Gault Equation and 24-hour Urine Collection in Gynecologic Cancer Patients

Objective To study the correlation between creatinine clearances, calculated by Cockcroft & Gault equation, and 24-hour urine collection in gynecological cancer patients treated with carboplatin. Materials &Methods Thirty-eight gynecological cancer patients who were treated with carboplatin at King Chulalongkorn Memorial Hospital from March 2008 to May 2009 were recruited. Creatinine clearances calculated by Cockcroft & Gault equation and 24-hour urine collection were compared. Data regarding age, height, lean body weight, and serum creatinine were also recorded. Result The mean age of the patients was 51.1 (SD = 8.4) years. The mean serum creatinine was 0.58 (SD = 0. 12) mg/dl. The mean creatinine clearance that was calculated by Cockcroft & Gault equation was 90.2 (SD=19.0) ml/min compared to 99.5 (SD = 21.8) ml/min estimated by 24-hour urine collection. Pearson correlation coefficient (r) between creatinine clearance calculated by Cockcroft & Gault equation and 24-hour urine collection was 0.61 (p < 0.01). Conclusion Moderate correlation between creatinine clearances calculated by Cockcroft & Gault equation and 24-hour urine collection in gynecological cancer patients was demonstrated

Knowledge regarding human papillomavirus and cervical cancer prevention among medical students from Chulalongkorn University in Thailand

Abstract Background Cervical cancer is one of the leading causes of death among women in Thailand. General practitioners, within their primary healthcare role, play a vital role in the cervical cancer screening program, as they are the healthcare professionals most easily accessible to the general population. This study aims to determine the level of knowledge of cervical cancer and human papillomavirus (HPV) infection, HPV vaccination, and cervical cancer screening among last-year medical students. Methods A cross-sectional study was conducted among sixth-year medical students using an electronic self-administered questionnaire. The two-part questionnaire comprised demographic data and 12 true/false questions that assessed knowledge regarding HPV infection, HPV vaccination, and cervical cancer screening recommendations. Pilot testing revealed a high Cronbach’s alpha and test–retest reliability coefficient. Results A 67% response rate was achieved. Among the 198 respondents, only one (0.5%) student correctly answered over 80% of the questions while most respondents (172, 71.7%) correctly answered less than 60% of the questions. Less than half of the respondents correctly identified crucial aspects such as the primary cause of cervical cancer, recommended vaccination age, cytology sensitivity compared to HPV testing, and the recommended screening frequency for average-risk women. Conclusions This study highlights a significant lack of comprehension among Thai medical students concerning HPV infection, vaccination, and cervical cancer screening guidelines. Encouraging educational enhancement, effective communication, and heightened awareness of these crucial topics within the medical school curriculum are imperative