13 research outputs found
Progressive damage on high resolution computed tomography despite stable lung function in cystic fibrosis
For effective clinical management of cystic fibrosis (CF) lung disease it
is important to closely monitor the start and progression of lung damage.
The aim of this study was to investigate the ability of high-resolution
computed tomography (HRCT) scoring systems and pulmonary function tests
(PFT) to detect changes in lung disease. CF children (n=48) had two H
Estimation of lung growth using computed tomography
Anatomical studies suggest that normal lungs grow by rapid alveolar
addition until about 2 yrs of age followed by a gradual increase in
alveolar dimensions. The aim of this study was to examine the hypothesis
that normal lung growth can be monitored by computed tomography (CT).
Therefore, the gas volume per gram of lung tissue was estimated from
measurements of lung density obtained from CT scans performed on children
throughout the growth period. CT scans were performed on 17 males and 18
females, ranging in age from 15 days-17.6 yrs. CT-measured lung weight was
correlated with predicted post mortem values and CT measured gas volume
with predicted values of functional residual capacity. The median value
for lung expansion was 1.86 mL x g(-1) at 15 days, decreased to 0.79 mL x
g(-1) by 2 yrs and then increased steadily to 5.07 mL x g(-1) at 17 yrs.
Computed tomography scans can be used to estimate lung weight, gas volume
and expansion of normal lungs during the growth period. The increase in
the lung expansion after the age of 2 yrs suggests progressive alveolar
expansion with increasing lung volume
Estimation of cancer mortality associated with repetitive computed tomography scanning
Rationale: Low-dose radiation from computed tomography (CT)
may increase the risk of certain cancers, especially in children.
Objective: We sought to estimate the excess all-cause and cancerspecific mort