21 research outputs found
Plasma pharmacokinetics after combined therapy of gemcitabine and oral S-1 for unresectable pancreatic cancer
<p>Abstract</p> <p>Background</p> <p>The combination of gemcitabine (GEM) and S-1, an oral 5-fluorouracil (5-FU) derivative, has been shown to be a promising regimen for patients with unresectable pancreatic cancer.</p> <p>Methods</p> <p>Six patients with advanced pancreatic cancer were enrolled in this pharmacokinetics (PK) study. These patients were treated by oral administration of S-1 30 mg/m<sup>2 </sup>twice daily for 28 consecutive days, followed by a 14-day rest period and intravenous administration of GEM 800 mg/m<sup>2 </sup>on days 1, 15 and 29 of each course. The PK parameters of GEM and/or 5-FU after GEM single-administration, S-1 single-administration, and co-administration of GEM with pre-administration of S-1 at 2-h intervals were analyzed.</p> <p>Results</p> <p>The maximum concentration (Cmax), the area under the curve from the drug administration to the infinite time (AUCinf), and the elimination half-life (T1/2) of GEM were not significantly different between GEM administration with and without S-1. The Cmax, AUCinf, T1/2, and the time required to reach Cmax (Tmax) were not significantly different between S-1 administration with and without GEM.</p> <p>Conclusion</p> <p>There were no interactions between GEM and S-1 regarding plasma PK of GEM and 5-FU.</p
Formation of two-dimensional weak localization in conducting Langmuir-Blodgett films
We report the magnetotransport properties up to 7 T in the organic highly
conducting Langmuir-Blodgett(LB) films formed by a molecular association of the
electroactive donor molecule bis(ethylendioxy)tetrathiafulvalene (BEDO-TTF) and
stearic acid CH(CH)COOH. We show the logarithmic decrease of dc
conductivity and the negative transverse magnetoresistance at low temperature.
They are interpreted in the weak localization of two-dimensional (2D)
electronic system based on the homogeneous conducting layer with the molecular
size thickness of BEDO-TTF. The electronic length with phase memory is given at
the mesoscopic scale, which provides for the first time evidence of the 2D
coherent charge transport in the conducting LB films.Comment: 5 pages, 1 Table and 5 figure
Probabilistic Interpretation of Resonant States
We provide probabilistic interpretation of resonant states. This we do by
showing that the integral of the modulus square of resonance wave functions
(i.e., the conventional norm) over a properly expanding spatial domain is
independent of time, and therefore leads to probability conservation. This is
in contrast with the conventional employment of a bi-orthogonal basis that
precludes probabilistic interpretation, since wave functions of resonant states
diverge exponentially in space. On the other hand, resonant states decay
exponentially in time, because momentum leaks out of the central scattering
area. This momentum leakage is also the reason for the spatial exponential
divergence of resonant state. It is by combining the opposite temporal and
spatial behaviors of resonant states that we arrive at our probabilistic
interpretation of these states. The physical need to normalize resonant wave
functions over an expanding spatial domain arises because particles leak out of
the region which contains the potential range and escape to infinity, and one
has to include them in the total count of particle number.Comment: 11 pages, 5 figures, to appear in Pramana Journal of Physics as an
article in the proceedings of Homi Bhabha Centenary Conference on
Non-Hermitian Hamiltonians in Quantum Physics PHHQP VIII; this version are
with added references as well as some rewording after reviewer's suggestion