Magnetohydrodynamic shocks in and above post-flare loops: two-dimensional simulation and a simplified model

Solar flares are an explosive phenomenon, where super-sonic flows and shocks are expected in and above the post-flare loops. To understand the dynamics of post-flare loops, a two-dimensional magnetohydrodynamic (2D MHD) simulation of a solar flare has been carried out. We found new shock structures in and above the post-flare loops, which were not resolved in the previous work by Yokoyama and Shibata 2001. To study the dynamics of flows along the reconnected magnetic field, kinematics and energetics of the plasma are investigated along selected field lines. It is found that shocks are crucial to determine the thermal and flow structures in the post-flare loops. On the basis of the 2D MHD simulation, we have developed a new post-flare loop model which we call the pseudo-2D MHD model. The model is based on the 1D MHD equations, where all the variables depend on one space dimension and all the three components of the magnetic and velocity fields are considered. Our pseudo-2D model includes many features of the multi-dimensional MHD processes related to magnetic reconnection (particularly MHD shocks), which the previous 1D hydrodynamic models are not able to include. We compare the shock formation and energetics of a specific field line in the 2D calculation with those in our pseudo-2D MHD model, and we found that they give similar results. This model will allow us to study the evolution of the post-flare loops in a wide parameter space without expensive computational cost and without neglecting important physics associated with magnetic reconnection.Comment: 51 pages, 22 figures. Accepted by Ap

Multiple-hypothesis vision-based landing autonomy

Unmanned aerial vehicles (UAVs) need humans in the mission loop for many tasks, and landing is one of the tasks that typically involves a human pilot. This is because of the complexity of a maneuver itself and flight-critical factors such as recognition of a landing zone, collision avoidance, assessment of landing sites, and decision to abort the maneuver. Another critical aspect to be considered is the reliance of UAVs on GPS (global positioning system). A GPS system is not a reliable solution for landing in some scenarios (e.g. delivering a package in an urban city, and a surveillance UAV repatriating a home ship with the jammed signals), and a landing solely based on a GPS extremely decreases the UAV operation envelope. Vision is promising to achieve fully autonomous landing because it is a rich-sensing, light, affordable device that functions without any external resource. Although vision is a powerful tool for autonomous landing, the use of vision for state estimation requires extensive consideration. Firstly, vision-based landing faces a problem of occlusion. The target detected at a high altitude would be lost at certain altitudes while a vehicle descends; however, a small visual target can not be recognized at high altitude. Second, standard filtering methods such as extended Kalman filter (EKF) face difficulty due to the complex dynamics of the measurement error created due to the discrete pixel space, conversion from the pixel to physical units, the complex camera model, and complexity of detection algorithms. The vision sensor produces an unfixed number of measurements with each image, and the measurements may include false positives. Plus, the estimation system is excessively tasked in realistic conditions. The landing site would be moving, tilted, or close to an obstacle. The available landing location may not be limited to one. In addition to assessing these statuses, understanding the confidence of the estimations is also the tasks of the vision, and the decisions to initiate, continue, and abort the mission are made based on the estimated states and confidence. The system that handles those issues and consistently produces the navigation solution while a vehicle lands eliminates one of the limitations of the autonomous UAV operation. This thesis presents a novel state estimation system for UAV landing. In this system, vision data is used to both estimate the state of the vehicle and map the state of the landing target (position, velocity, and attitude) within the framework of simultaneous localization and mapping (SLAM). Using the SLAM framework, the system becomes resilient to a loss of GPS and other sensor failures. A novel vision algorithm that detects a portion of the marker is developed, and the stochastic properties of the algorithm are studied. This algorithm extends the detectable range of the vision system for any known marker. However, this vision algorithm produces highly nonlinear, non-Gaussian, and multi-modal error distribution, and a naive implementation of filters would not accurately estimate the states. A vision-aided navigation algorithm is derived within extended Kalman particle filter (PF-EKF) and Rao-Blackwellized particle filter (RBPF) frameworks in addition to a standard EKF framework. These multi-hypothesis approaches not only deal well with a highly nonlinear and non-Gaussian distribution of the measurement errors of vision but also result in numerically stable filters. The computational costs are reduced compared to a naive implementation of particle filter, and these algorithms run in real time. This system is validated through numerical simulation, image-in-the-loop simulation, and flight tests.Ph.D

Fingering behavior of flame spread over solid combustibles

In this study, the fingering pattern formation and the following flamelet spreading over three different kinds of thick combustibles, i.e., Poly methacrylate (PMMA), Poly ethylene (PE) and Poly carbonate (PC) were observed and the effective Lewis number correlation was validated. Experiments were performed with a narrow channel apparatus. In addition to the kinds of solid fuel materials, the channel height and the oxidizer velocity were varied as experimental parameters. An image analysis method was developed to quantify the number, diameter and spread rate of the flamelets. Replacing the fuel thickness into the thermal thickness, the effective Lewis number which is proposed for the smoldering combustion of thin fuel is remedied to include heat transfer perpendicular to the fuel surface. The result validates that the appearance condition of the fingering instability for thick combustibles is determined by the effective Lewis number. Hence, it is concluded that the observed phenomenon is inherently similar to that of smoldering. Further, it is shown that the non-dimensional flame diameter becomes nearly constant when the fingering instability occurs. It is believed that the correlation is useful when one wants to reproduce this phenomenon in a larger scale experiment

Development of spontaneous neuropathy in NF-κBp50-deficient mice by calcineurin-signal involving impaired NF-κB activation

信州大学博士（医学）・学位論文・平成24年3月28日授与（乙第21144号）・中村朋子Purpose: The transcriptional regulator, nuclear factor-kappa B (NF-kappa B)/Rel family are involved in neuronal cell death and survival. Previously, we reported that NF-kappa Bp50-deficient (p50-deficient) mice exhibit many features resembling human normal tension glaucoma (NTG). The developmental mechanism of human NTG is not clearly understood, and a radical curative treatment has yet to be established. Our aim is to elucidate the signal cascade which mediates the spontaneous optic neuropathy in p50-deficient mice as a model of NTG. Methods: To demonstrate the expression and activation of pro-apoptotic factors, which mediate the death of retinal ganglion cells (RGCs) in p50-deficient mice, western blot (WB) and luciferase reporter assays with retinas from p50-deficient and wild type mice, and cultured RGC-5 cells were performed. Furthermore, we tested the neuroprotective effects of chemical reagents (memantine, lomerizine, and tacrolimus) against N-methyl-D-aspartate (NMDA)-susceptible RGC damage according to in vitro experiments with RGC-5 cells. To elucidate the NF-kappa B-mediated death signaling, the effects of chemical reagents on spontaneous optic neuropathy were examined by histopathological studies. Results: WB experiments and luciferase reporter assays showed that NF-kappa B-inducible BCL2-associated X protein (Bax) and a pro-apoptotic factor, activated caspase 3 were expressed in the retina of p50-deficient mice as well as NMDA-treated RGC-5 cells. Further, the constitutively active cleaved forms of calcineurin (CaN), which have been reported to lead to apoptosis, were detected in the retina of p50-deficient mice as well as NMDA-treated RGC-5 cells. Pre-treatment with tacrolimus markedly protected RGC-5 cells from NMDA-induced neurotoxicity, and then both spontaneous RGC death and degenerative changes to the optic nerve in p50-deficient mice were significantly reduced by the chronic administration of tacrolimus. The experiments with cultured RGC-5 cells supported the results of histological examinations with p50-deficient mice, suggesting that CaN activation leads to NF-kappa B-induced Bax activation and caspase 3 activation, and mediates spontaneous optic neuropathy in p50-deficient mice. Conclusions: Research findings show that the chronic administration of tacrolimus significantly reduces spontaneous optic neuropathy in p50-deficient mice. We demonstrated a potential CaN signal cascade, which spontaneously induces age-dependent RGC death and degenerative optic nerve changes in p50-deficient mice.ArticleMOLECULAR VISION. 17:2157-2170 (2011)journal articl

Development of spontaneous neuropathy in NF-kappa Bp50-deficient mice by calcineurin-signal involving impaired NF-kappa B activation

信州大学博士（医学）・学位論文・平成24年3月28日授与（乙第21144号）・中村朋子Purpose: The transcriptional regulator, nuclear factor-kappa B (NF-kappa B)/Rel family are involved in neuronal cell death and survival. Previously, we reported that NF-kappa Bp50-deficient (p50-deficient) mice exhibit many features resembling human normal tension glaucoma (NTG). The developmental mechanism of human NTG is not clearly understood, and a radical curative treatment has yet to be established. Our aim is to elucidate the signal cascade which mediates the spontaneous optic neuropathy in p50-deficient mice as a model of NTG. Methods: To demonstrate the expression and activation of pro-apoptotic factors, which mediate the death of retinal ganglion cells (RGCs) in p50-deficient mice, western blot (WB) and luciferase reporter assays with retinas from p50-deficient and wild type mice, and cultured RGC-5 cells were performed. Furthermore, we tested the neuroprotective effects of chemical reagents (memantine, lomerizine, and tacrolimus) against N-methyl-D-aspartate (NMDA)-susceptible RGC damage according to in vitro experiments with RGC-5 cells. To elucidate the NF-kappa B-mediated death signaling, the effects of chemical reagents on spontaneous optic neuropathy were examined by histopathological studies. Results: WB experiments and luciferase reporter assays showed that NF-kappa B-inducible BCL2-associated X protein (Bax) and a pro-apoptotic factor, activated caspase 3 were expressed in the retina of p50-deficient mice as well as NMDA-treated RGC-5 cells. Further, the constitutively active cleaved forms of calcineurin (CaN), which have been reported to lead to apoptosis, were detected in the retina of p50-deficient mice as well as NMDA-treated RGC-5 cells. Pre-treatment with tacrolimus markedly protected RGC-5 cells from NMDA-induced neurotoxicity, and then both spontaneous RGC death and degenerative changes to the optic nerve in p50-deficient mice were significantly reduced by the chronic administration of tacrolimus. The experiments with cultured RGC-5 cells supported the results of histological examinations with p50-deficient mice, suggesting that CaN activation leads to NF-kappa B-induced Bax activation and caspase 3 activation, and mediates spontaneous optic neuropathy in p50-deficient mice. Conclusions: Research findings show that the chronic administration of tacrolimus significantly reduces spontaneous optic neuropathy in p50-deficient mice. We demonstrated a potential CaN signal cascade, which spontaneously induces age-dependent RGC death and degenerative optic nerve changes in p50-deficient mice.ArticleMOLECULAR VISION. 17:2157-2170 (2011)journal articl

オフセットフリー光周波数コムの開発と固体精密分光への応用

学位の種別: 課程博士審査委員会委員 : （主査）東京大学准教授 小林 洋平, 東京大学特任教授 三尾 典克, 東京大学准教授 吉岡 孝高, 東京大学講師 井手口 拓朗, 横浜国立大学教授 洪 鋒雷University of Tokyo(東京大学