Optimization of two-stage production/inventory systems under order base stock policy with advance demand information

It is important to share demand information among the members in supply chains. In recent years, production and inventory systems with advance demand information (ADI) have been discussed, where advance demand information means the information of demand which the decision maker obtains before the corresponding actual demand arrives. Appropriate production and inventory control using demand information leads to the decrease of inventory and backlog costs. For a single stage system, the optimal base stock and release lead time have been discussed in the literature. In practical production systems the manufacturing system has multiple processes. The multiple stage production and inventory system with ADI, however, has been analyzed by simulation or assuming exponential processing time. That is, their theoretical analysis and optimization of release lead time and base stock level have little been obtained because of its difficulty. In this paper, theoretical analysis of a two-stage production inventory system with advance demand information is developed, where the processing time is assumed deterministic and identical; demand arrival process is Poisson, and an order base stock policy is adopted. Using the analytical results, optimal release lead time and optimal base stock levels for minimizing the average cost on the holding and backlog costs are explicitly derived

Distally based split vastus lateralis myocutaneous flap for reconstruction of post electrical injury defects around knee joint

Background: Large soft tissue defects around knee joint remains challenge to reconstructive surgeon due to limited size of local fasciocutaneous flap or muscles flaps and deeper recipient vessels for free flap. Presence of electrical injury further makes it difficult due to progressive necrosis of tissue and vessel damage. We present our experience with distally based split vastus lateralis myocutaneous flap for post electric burns large soft tissue defect over knee with open knee joint in three patients.Methods: Distally based split vastus lateralis myocutaneous flap was done in three patients for large soft tissue defects over knee secondary to electric contact burns. Two of the three patients had wound with open knee joint draining synovial fluid. All patients needed skin grafting for donor area of flap. Patients were followed up for functional outcome of knee and appearance of donor area.Results: Two out of three patients had uneventful recovery. One patient with skin paddle size 24 x 17 cm. developed necrosis of distal 2-3 cm. of skin and muscle which was managed by excision of necrosed flap with advancement. Donor area of flap was skin grafted in all three patients which healed without any complications. Postoperative knee function was normal in two patients.Conclusions: This new flap is a reliable option for extensive soft tissue defects around knee secondary to high voltage electric burns where free flap is challenging due to deeper location of recipient vessels and damage due to burn injury. Donor area in upper thigh remains hidden and is with no functional deficit

細胞におけるTALENやCRISPR/Cas9を用いたドナーDNAのマイクロホモロジー媒介末端結合依存的な挿入

内容の要約広島大学(Hiroshima University)博士(理学)Doctor of Sciencedoctora