A New Perspective on the Development of Cholesterol- Lowering Products

Cardiovascular disease (CVD) is the principal cause of death worldwide, representing nearly 30% of the annual global mortality and 10% of global health burden. The current status of CVD is now on international scale; which can be considered as the commonest chronic illness in both developed and developing countries, causing the most deaths and the greatest impact on morbidity. In 2006, CVD was the leading cause of death for Canadians, representing 30% of all deaths. A total number of 1.3 million Canadians are diagnosed having heart disease accounting for 5% among those above 12 years and 23% at 75 years and older. The increased rate of obesity and diabetes combined with further aging of the population will likely lead to an increase in the number of people with CVD in the future. This will compromise the health of Canadians, put a strain on the health care system, and have a significant economic impact on Canada. Similarly, over the past five decades the prevalence of CVD has steadily increased in economically developing countries. These countries will account for 76% of an estimated 25 million death due to CVD in 2020. On an international basis, by 2020 CVD will reach nearly epidemic proportions and become the cause of more deaths, disability and economic loss than any others group of diseases. The number of fatalities by CVD projected to increase to over 20 million a year by 2020 and over 24 million a year by 2030. Apparently, understanding the aetiology of CVD and accordingly develop preventive and therapeutic approaches to address this health threat continues to be critically important in the next decades although significant achievements have been made in the past decades.Peer reviewed: YesNRC publication: Ye

Dynamics of a Dirac Fermion in the presence of spin noncommutativity

Recently, it has been proposed a spacetime noncommutativity that involves spin degrees of freedom, here called "spin noncommutativity". One of the motivations for such a construction is that it preserves Lorentz invariance, which is deformed or simply broken in other approaches to spacetime noncommutativity. In this work, we gain further insight in the physical aspects of the spin noncommutativity. The noncommutative Dirac equation is derived from an action principle, and it is found to lead to the conservation of a modified current, which involves the background electromagnetic field. Finally, we study the Landau problem in the presence of spin noncommutativity. For this scenario of a constant magnetic field, we are able to derive a simple Hermitean non-commutative correction to the Hamiltonian operator, and show that the degeneracy of the excited states is lifted by the noncommutativity at the second order or perturbation theory.Comment: 18 pages, revtex

Path integral representations in noncommutative quantum mechanics and noncommutative version of Berezin-Marinov action

It is known that actions of field theories on a noncommutative space-time can be written as some modified (we call them $\theta$-modified) classical actions already on the commutative space-time (introducing a star product). Then the quantization of such modified actions reproduces both space-time noncommutativity and usual quantum mechanical features of the corresponding field theory. The $\theta$-modification for arbitrary finite-dimensional nonrelativistic system was proposed by Deriglazov (2003). In the present article, we discuss the problem of constructing $\theta$-modified actions for relativistic QM. We construct such actions for relativistic spinless and spinning particles. The key idea is to extract $\theta$-modified actions of the relativistic particles from path integral representations of the corresponding noncommtative field theory propagators. We consider Klein-Gordon and Dirac equations for the causal propagators in such theories. Then we construct for the propagators path-integral representations. Effective actions in such representations we treat as $\theta$-modified actions of the relativistic particles. To confirm the interpretation, we quantize canonically these actions. Thus, we obtain the Klein-Gordon and Dirac equations in the noncommutative field theories. The $\theta$-modified action of the relativistic spinning particle is just a generalization of the Berezin-Marinov pseudoclassical action for the noncommutative case

Topics in Noncommutative Geometry Inspired Physics

In this review article we discuss some of the applications of noncommutative geometry in physics that are of recent interest, such as noncommutative many-body systems, noncommutative extension of Special Theory of Relativity kinematics, twisted gauge theories and noncommutative gravity.Comment: New references added, Published online in Foundations of Physic

Global Retinoblastoma Presentation and Analysis by National Income Level

Importance: Early diagnosis of retinoblastoma, the most common intraocular cancer, can save both a child's life and vision. However, anecdotal evidence suggests that many children across the world are diagnosed late. To our knowledge, the clinical presentation of retinoblastoma has never been assessed on a global scale. Objectives: To report the retinoblastoma stage at diagnosis in patients across the world during a single year, to investigate associations between clinical variables and national income level, and to investigate risk factors for advanced disease at diagnosis. Design, Setting, and Participants: A total of 278 retinoblastoma treatment centers were recruited from June 2017 through December 2018 to participate in a cross-sectional analysis of treatment-naive patients with retinoblastoma who were diagnosed in 2017. Main Outcomes and Measures: Age at presentation, proportion of familial history of retinoblastoma, and tumor stage and metastasis. Results: The cohort included 4351 new patients from 153 countries; the median age at diagnosis was 30.5 (interquartile range, 18.3-45.9) months, and 1976 patients (45.4) were female. Most patients (n = 3685 84.7%) were from low-and middle-income countries (LMICs). Globally, the most common indication for referral was leukocoria (n = 2638 62.8%), followed by strabismus (n = 429 10.2%) and proptosis (n = 309 7.4%). Patients from high-income countries (HICs) were diagnosed at a median age of 14.1 months, with 656 of 666 (98.5%) patients having intraocular retinoblastoma and 2 (0.3%) having metastasis. Patients from low-income countries were diagnosed at a median age of 30.5 months, with 256 of 521 (49.1%) having extraocular retinoblastoma and 94 of 498 (18.9%) having metastasis. Lower national income level was associated with older presentation age, higher proportion of locally advanced disease and distant metastasis, and smaller proportion of familial history of retinoblastoma. Advanced disease at diagnosis was more common in LMICs even after adjusting for age (odds ratio for low-income countries vs upper-middle-income countries and HICs, 17.92 95% CI, 12.94-24.80, and for lower-middle-income countries vs upper-middle-income countries and HICs, 5.74 95% CI, 4.30-7.68). Conclusions and Relevance: This study is estimated to have included more than half of all new retinoblastoma cases worldwide in 2017. Children from LMICs, where the main global retinoblastoma burden lies, presented at an older age with more advanced disease and demonstrated a smaller proportion of familial history of retinoblastoma, likely because many do not reach a childbearing age. Given that retinoblastoma is curable, these data are concerning and mandate intervention at national and international levels. Further studies are needed to investigate factors, other than age at presentation, that may be associated with advanced disease in LMICs. © 2020 American Medical Association. All rights reserved

The training of technician engineers at Brico Engineering Limited

The training of technician engineers at Brico Engineering Limite

Initiatives and Learnings from World Healthcare Models

International audienceThe global healthcare industry is one of the largest and fastest-growing service industries in the world. The respective benefits of public and private healthcare systems are continually debated, but a third way-that of healthcare cooperatives-is emerging as an alternative method for managing the well-being of the population. There is a growing demand for bringing together successful cases and models of healthcare cooperatives across the world. This chapter focuses on the initiatives of successful healthcare cooperative models from different parts of the world. The chapter highlights the Health cooperative's capability to deliver positive outcomes through healthcare services that are sustained through the collaborative efforts of their members, with remarkable examples and models established in every corner of the world. Such cooperatives provide hospitals and infrastructure, medical facilities, biotechnology, information technology, and all other healthcare services. With this objective, the chapter will help to understand the initiatives in healthcare cooperatives in different parts of the world. © 2024 by Sneha Kumari, V. G. Venkatesh, Priyanka Sunil Kothmire, M. P. Sukumaran Nair and K. K. Tripathy