Abridgment Of Nano And Micro Length Scale Mechanical Properties Of Novel Mg-9Li-7Al-1Sn And Mg-9Li-5Al-3Sn-1Zn Alloys Using Object Oriented Finite Element Modeling

In the recent years, magnesium-lithium (Mg-Li) alloys have attracted considerable attention/interest due to their high strength-to-density ratio and damping characteristic; and have found potential use in structural and biomedical applications. Here the mechanical behavior of novel Mg-9 wt.% Li-7 wt.% Al-1 wt.% Sn (LAT971) and Mg-9 wt.% Li-5 wt.% Al-3 wt.% Sn-1 wt.% Zn (LATZ9531) alloys is reported. Both, as cast and thermomechanically processed alloys have been studied which possess dual phase microstructure. Nanoindentation data have been utilized to envisage the elastic modulus of alloy via various micromechanics models (such as rule of mixtures, Voigt-Reuss, Cox model, Halpin-Tsai and Guth model) in order to estimate the elastic modulus. Object oriented finite element modeling (FEM) has been performed to predict stress distribution under tensile and compressive strain state. Close match between Halpin-Tsai model and FEM results show the abridgment of nano length scale property to evolution of microscopic stress distribution in novel LAT971 and LATZ9531 Mg-Li-Al based alloys

A crosssectional observational research on assessment of patterns of discharge medications in patients with chronic kidney disease associated with diabetes mellitus and hypertension

Background: Chronic kidney disease (CKD), also known as chronic renal insufficiency, progressive kidney deterioration, or nephropathy, is an illness, in which the kidneys fail to function properly. When prescription and over-the-counter medications are combined, the risk of adverse drug reactions and interactions increases, which are the main causes of hospitalizations and mortality. The aims and strategies for reducing the incidence, morbidity, mortality, and health costs of CKD in India are outlined in this new chapter. Aim: A cross-sectional observational study to estimate the pattern of discharge prescription pattern in patients of CKD associated with hypertension and diabetes mellitus. Methodology: 100 patients with CKD and comorbidities of hypertension, diabetes, or both were included in observational cross-sectional research done at the Nephrology Department of Dhiraj Hospital. The laboratory findings, as well as their comorbidity, discharge prescription medicines, and comorbidity, were all documented and examined. Results: Calcium channel blockers (CCBs) were the most often recommended antihypertensive medication for hypertensive patients with CKD. Diuretics were the least often given class of antihypertensive medicine. In antidiabetic medication, class sulfonylurea and dipeptidyl peptidase-4 inhibitors had similar prescription rates which are the highest prescribing medication for diabetes mellitus with CKD. Biguanides were the least prescribed class of drugs. Conclusion: Angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers are widely used to treat hypertensive patients with CKD; but due to chances of arrhythmia, CCBs are prescribed. This research might aid in the identification of educational and quality-improvement opportunities to minimize medication-related errors and increase benefits in this population