2 research outputs found
Comparative study of human papilloma virus DNA detection and results of histopathological examination of cervical colposcopic biopsy
Background: There is mounting evidence for HPV involvement in cervical
cancer Human Papilloma Virus DNA is detected by hybridization
techniques in 75 - 100% of patients with condylomas, precancerous
cervical dysplasia, and invasive carcinoma. Objective: The aim of this
study was investigating factors that may contribute to false-negative
colposcopic biopsy results in positive high-risk HPV DNA results.
Material and Methods: Patients positive for high-risk human
papillomavirus (HPV) DNA with negative cervical histopathologic
findings were examined between January 2004 and August 2006. Results:
Patients with atypical squamous cells of undetermined significance
(ASC) in Papanicolaou smears, with positive HPV DNA results, but
negative cervical histopathologic findings accounted for 4.5% of all
ASC smears submitted for HPV DNA testing. We found 4% of the cases had
focal HPV infection or mild dysplasia. When serial sectioning of the
biopsy material were examined, we found that 29% had clinically
significant lesions: HPV infection or cervical intraepithelial
neoplasia CIN 1, 18%; CIN II/III, 8%; and dysplasia, not otherwise
specified (which we can not categorize into any group), 3%. Of the
remaining patients, follow-up revealed squamous abnormalities in 25%.
About 5% of patients with positive HPV DNA results had a negative
follow-up biopsy result. "False-negative" biopsies accounted for one
third of cases. Conclusion: In almost one third of cases, clinically
significant lesions were found when additional levels were examined
The effect of high oral loading dose of cholecalciferol in non-alcoholic fatty liver disease patients. A randomized placebo controlled trial
Background and Aim: Non-alcoholic fatty liver (NAFLD) is one of the most common progressive metabolic disorders worldwide. There are increasing scientific interests nowadays for the association between vitamin D status and Non-alcoholic fatty liver. Earlier studies have revealed that vitamin D deficiency is highly prevalent in Non-alcoholic fatty liver patients that contributes to poor outcomes. Hence, the present study aimed to assess the efficacy and safety of oral cholecalciferol on Non-alcoholic fatty liver patients.Subjects and Methods: This study was conducted on 140 patients that were randomized either to group 1 that received the standard conventional therapy in addition to placebo or group 2 that received the standard conventional therapy in addition to cholecalciferol during the 4 months study period.Results: At the end of the study group 2 revealed significant decrease (p < 0.05) in the mean serum level of TG, LDL-C, TC, hsCRP as compared to their baseline results and group 1 results. Additionally, a significant improvement in the serum levels of ALT (p = 0.001) was seen in group 2 at the end of the study when compared to group 1. Whereas group 1 did not show any change in these parameters when compared to group 2 and their baseline results.Conclusion: Cholecalciferol was shown to have beneficial effects on serum ALT levels, hsCRP levels and lipid profile of NAFLD patients.Clinical Trial Registration:https://prsinfo.clinicaltrials.gov/prs-users-guide.html, identifier NCT0561319