38 research outputs found
Hepatocellular Carcinoma and Sex Hormones
The liver is morphologically and functionally modulated by sex hormones. Long-term use of oral
contraceptives and androgenic steroids can induce benign and malignant hepatocellular tumors.
Hepatocellular carcinoma (HCC) is more prevalent in men than in women. The role of sex hormones
and their receptors in the development of HCC was reviewed. Some HCCs may be androgen dependent
but others may be estrogen or even both dependent. Further studies are mandatory in order to utilize
such characteristics of HCC for an effective prophylaxis and therapy of this tumor
Clinical and Enzymatic Investigation of Induction of Oxygen Free Radicals by Ischemia and Reperfusion in Human Hepatocellular Carcinoma and Adjacent Liver
Serum concentration of thiobarbituric acid (TBA) reactants in the hepatic vein were measured before
and after transient dearterialization of the liver in five human subjects bearing unresectable
hepatocellular carcinoma (HCC). During 1 hour of the occlusion of the hepatic artery, change inTBA
reactants level was slight. However, the mean value of TBA reactants in 1 hour after the reflow
increased to 1.50 ± 0.11 nmol/ml (mean ± S.E.) and was significantly higher (p < 0.05) than those
before hepatic dearterialization (1.28 ± 0.11 nmol/ml) and just before the release of occlusion (1.32 ±
0.09 nmol/ml)
Synergistic effect of ubiquitin on lipopolysaccharide-induced TNF-α production in murine macrophage cell line RAW 264.7 cells
AbstractUbiquitin synergistically augmented the production of tumor necrosis factor alpha (TNF-α) in the presence of lipopolysaccharide (LPS) in murine macrophage cell line RAW 264.7. To investigate the mechanism of this augmentation, we analyzed the effect of ubiquitin during TNF-α mRNA synthesis and degradation, and TNF-α degradation on RAW 264.7 cells stimulated by LPS. It is found that ubiquitin augmented TNF-α mRNA synthesis. Ubiquitin did not affect the degradation of TNF-α mRNA and TNF-α. In the presence of LPS, extracellular accumulation of TNF-α by ubiquitin was twice than those by LPS, but intracellular accumulation of TNF-α produced by ubiquitin with LPS or by LPS had no difference. These data indicate that ubiquitin might induce TNF-α accumulation mainly by up-regulation of the TNF-α gene transcription. Although extracellular functions of ubiquitin remain largely unknown, we postulate that ubiquitin might be involved in the modulatory mechanisms of immune response
Inferior Vena Caval Thrombosis After Traumatic Liver Injury
We report here the case of a 35-year-old man who
presented with inferior vena cava thrombosis
(IVCT) after blunt hepatic trauma. The IVCT was
incidentally detected by computed tomography (CT)
35 days after deep parenchymal suturing and suture
approximation for liver lacerations. The patient
denied any symptoms of thrombophlebitis. However,
he had presented with significantly elevated
values of FDP-D-dimer and a modest increase in
plasminogen concentration, which indicated that he
had been in a hypercoagulable and hypofibrinolytic
state after the operation. He had not undergone any
prophylactic anticoagulant therapy because of his
concomitant subarachnoid hemorrhage and huge
hepatic hematoma. The patient was treated with an
emercy thrombectomy. Posttraumatic IVCT is extremely
rare phenomenon. We should consider IVCT
in patients with a severe hepatic injury, particularly
if their coagulation system change into hypercoagulable
and hypofibrinolytic state. Additionally, this
case made us reflect on the treatment of traumatic
liver injury
Repeated Hepatic Dearterialization for Unresectable Liver Metastases From Gastric Cancer: Review of Five Cases
A novel method of repeated hepatic dearterialization was evaluated in five patients with multiple
metastases from gastric cancer in both hepatic lobes. After gastrectomy with extensive lymph node
dissection (R2/3), all patients underwent implantation of a vascular occluder around the hepatic
artery. Cannulation of the hepatic artery was added for later chemotherapy. The hepatic artery was
occluded repeatedly for 1 hour twice daily in combination with intrahepatic infusion of anticancer
drugs for as long as possible. Three of five patients demonstrated marked tumour regression with
unexpectedly long survival (16 months in two patients and one still alive at 15 months).
Carcinoembryonic antigen (CEA) levels decreased to almost normal in four patients who had initially
high levels. The present experiences seems to indicate that long survival can be hoped for in patients
with advanced gastric cancer with unresectable liver metastases