Association of Inflammatory and Oxidative Stress Markers with Metabolic Syndrome in Asian Indians in India

Metabolic syndrome (MetS) is a primary risk factor for cardiovascular disease and is associated with a proinflammatory state. Here, we assessed the contribution of inflammatory and oxidative stress markers towards prediction of MetS. A total of 2316 individuals were recruited in Phase I of the Indian Atherosclerosis Research Study (IARS). Modified ATPIII guidelines were used for classification of subjects with MetS. Among the inflammatory and oxidative stress markers studied, levels of hsCRP (P < .0001), Neopterin (P = .036), and oxLDL (P < .0001) were significantly higher among subjects with MetS. Among the markers we tested, oxLDL stood out as a robust predictor of MetS in the IARS population (OR 4.956 95% CI 2.504–9.810; P < .0001) followed by hsCRP (OR 1.324 95% CI 1.070–1.638; P = .010). In conclusion, oxLDL is a candidate predictor for MetS in the Asian Indian population

Correlation of Leptin Levels and Total Body Fat in Patients with Chronic Kidney Disease on Hemodialysis

ABSTRACT Anorexia is a known complication of uraemia which worsens with the progress of renal failure. Malnutrition and reduction in lean body mass is seen in patients undergoing dialysis. Serum leptin levels are elevated in patients with chronic kidney disease (CKD). Serum leptin level is suggested to control appetite and metabolism. The aim of the study is to establish a relationship between serum leptin levels and total body fat in normal subjects and patients undergoing hemodialysis for chronic kidney disease. Serum leptin levels were measured in 25 patients undergoing hemodialysis and 25 anthropometrically matched control subjects. Body mass index (BMI) and total body fat percentage were measured. The correlation between serum leptin levels, BMI and total body fat percentage was evaluated. Serum leptin levels in cases and controls were 16.38 ± 31.59 ng/ml and 3.91 ± 4.15 ng/ml respectively. Total body fat percentage in cases and controls were 25.76 ±7.22 and 19.42 ± 6.0 respectively. Serum leptin levels were higher in cases when compared to controls. Positive correlation was found between serum leptin levels and total body fat percentage