Genetic Background of Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy: Time to Start Asian Registry!

AbstractArrhythmogenic right venticular dysplasia/cardiomyopathy (ARVD/C) is an inherited cardiomyopathy with a very low penetrance affecting the right ventricle (RV) and presenting palpitation and syncope due to ventricular tachycardia (VT) originating from RV. The VT can degenerate into ventricular fibrillation and sudden cardiac death. The genetic background of ARVD/C has recently been found to be heterogeneous, mainly resulting from cell adhesion abnormalities due to mutations in five different genes encoding members of the desmosome complex. In Asian countries, however, the genetic aspect of the disease has not been fully studied, although the clinical features of Asian ARVD/C patients are different from those in Western countries in the penetrance of phenotypes, relation to Brugada syndrome and link to RV outflow tract ventricular tachycardia. It is of urgent need to have a registry of Asian ARVD/C patients and to conduct a more detailed genetic survey on the candidate genes, including desomosomal ones

XQsim: Modeling Cross-Technology Control Processors for 10+K Qbit Qantum Computers

© 2022 Copyright held by the owner/author(s). Publication rights licensed to ACM.10+K qubit quantum computer is essential to achieve a true sense of quantum supremacy. With the recent effort towards the large-scale quantum computer, architects have revealed various scalability issues including the constraints in a quantum control processor, which should be holistically analyzed to design a future scalable control processor. However, it has been impossible to identify and resolve the processor's scalability bottleneck due to the absence of a reliable tool to explore an extensive design space including microarchitecture, device technology, and operating temperature. In this paper, we present XQsim, an open-source cross-technology quantum control processor simulator. XQsim can accurately analyze the target control processors' scalability bottlenecks for various device technology and operating temperature candidates. To achieve the goal, we frst fully implement a convincing control processor microarchitecture for the Fault-tolerant Quantum Computer (FTQC) systems. Next, on top of the microarchitecture, we develop an architecture-level control processor simulator (XQsim) and thoroughly validate it with post-layout analysis, timing-accurate RTL simulation, and noisy quantum simulation. Lastly, driven by XQsim, we provide the future directions to design a 10+K qubit quantum control processor with several design guidelines and architecture optimizations. Our case study shows that the fnal control processor architecture can successfully support ~59K qubits with our operating temperature and technology choices.N