Gold mineralization in the Hutti Mining Area, Karnataka, India. A reply

A polemic in reply to A. Roy (ibid., 450)​. The paper was intended to be a broad-​based summary of Au ore mineralization at the Hutti Mine (Karnataka, India)​. The main structural-​tectonic framework was earlier described by K. K. Raju (1978)​

Minerographic study of some of the sulfide ore from Ingaldhal, Chitaldurg district, Mysore state

Mineragraphic study of the ore samples collected from Ingaldhal Cu mines shows that the ore are largely massive, banded, and disseminated in structure. The primary minerals are pyrite, arsenopyrite, cobaltite, sphalerite, pyrrhotite, galena, and chalcopyrite and the secondary pyrrhotite, chalcopyrite, stromeyerite, bornite, chalcocite, and tennantite as secondary minerals are present. The ore exhibit inclusion, panidiomorphism, mutual boundary, exsoln., and replacement textures. From the mineralogical assemblage and the textures it is inferred that the ore deposits were formed at 350-​500°. The entire sulfide ore mineralization in the Ingaldhal area was brought about by hydrothermal processes, the pyrite ore exhibiting the sedimentary features being diplogenic

Minerographic study of some of the sulphide ores from ingaldhal, chitaldurg district, mysore state

Minerographic study of the ore samples collected from Ingaldhal copper mines shows that the ores are largely massive, banded and disseminated in structure. Pyrite, arsenopyrite, cobaltite, sphalerite, pyrrhotite, galena and chalcopyrite as primary minerals and pyrrhotite, chalcopyrite, stromyerite, bornite, chalcocite and tennantite as secondary minerals are present. The ores exhibit inclusion, panidiomorphic, mutual boundary, exsolution and replacement textures. From the mineralogical assemblage and the textures it is inferred that the ore deposits were formed inthe temperature range of 350°–500° C

Study of the nickel silicates associated with the ultrabasic rocks of Nuggihalli schist belt, mysore state

The occurrence of some nickel silicate minerals as encrustations along joint planes and shear zones of the chromite bearing ultrabasic rocks of Nuggihalli schist belt is described. Chemical and X-ray study shows besides amorphous nickel silicate, the presence of granierite, nepouite or nickel antigorite. The nickel minerals are secondary developed by the action of circulating waters. The source of nickel is olivine, in the structure of which Ni is known to be present, either as camouflaged or captured ion

Occurrence of cubanite and pyrargyrite in the sulphide ores of Ingaldhal, Chitradurga district, Mysore state

Cubanite occurs as small veinlets in chalcopyrite and as anhedral aggregates of small grains. Individual grains or aggregates are not common. Pyrargyrite occurs as unoriented grains in chalcopyrite. Cubanite was reported from liq. magmatic, pegmatitic, pneumatolytic, and hydrothermal veins. The presence of Cubanite in the S ores shows that the complex ore deposition is formed by hydrothermal process at temps. >250°. Pyrargyrite is an earlier mineral formed through the hydrothermal process

Preliminary Phytochemical Analysis and Antioxidants Activities of Ethanolic Extract from Gomphrena serrata Whole Plant

The present study was designed to investigate the phytochemical analysis and antioxidant activities of the whole plant of Gomphrena serrata. Gomphrena serrata widely distributed in South America, North America, and India. These plant parts are used as traditional medicine for the treatment of several ailments. This study aims to assess the phytochemical and free radical scavenging of ethanolic extract of G. serrata present in the plant. The preliminary phytochemical study was performed by standard method. The whole plant of G. serrata proved the presence of bioactive constituents such as carbohydrates, alkaloids, steroids, glycosides, triterpenoids, protein and amino acids, saponins, as well as flavonoids. The in-vitro antioxidant study was performed on the ethanolic extract of shade-dried of the whole plant, which determined by hydrogen peroxide, hydroxyl radical, and 1,1-diphenyl-2-picrylhydrazyl (DPPH) 100 µg/ml assay and was compared to ascorbic acid. The ethanolic extract of the whole plant of G. serrata shows the strong free radical scavenging activity. The present study was the proof for ethanol extract of G. serrata which have medicinally significant and bioactive compounds since these plant species are used as traditional medicine for the treatment of various diseases

Amino Alkynylisoquinoline and Alkynylnaphthyridine Compounds Potently Inhibit Acute Myeloid Leukemia Proliferation in Mice

B ackground: Acute myeloid leukemia (AML) remains one of the most lethal, rarely cured cancers, despite decades of active development of AML therapeutics. Currently, the 5-year survival of AML patients is about 30% and for elderly patients, the rate drops to b10%. About 30% of AML patients harbor an activating mutation in the tyrosine kinase domain (TKD) of Fms-Like Tyrosine kinase 3 (FLT3) or a FLT3 internal tandem duplication (FLT3-ITD). In- hibitors of FLT3, such as Rydapt that was recently approved by the FDA, have shown good initial response but pa- tients often relapse due to secondary mutations in the FLT3 TKD, like D835Y and F691 L mutations. Methods: Alkynyl aminoisoquinoline and naphthyridine compounds were synthesized via Sonogashira coupling. The compounds were evaluated for their in vitro and in vivo effects on leukemia growth. Findings: The compounds inhibited FLT3 kinase activity at low nanomolar concentrations. The lead compound, HSN431, also inhibited Src kinase activity. The compounds potently inhibited the viability of MV4–11 and MOLM-14 AML cells with IC50 values b1 nM. Furthermore, the viability of drug-resistant AML cells harboring the D835Y and F691 L mutations were potently inhibited. In vivo efficacy studies in mice demonstrated that the compounds could drastically reduce AML proliferation in mice. Interpretation: Compounds that inhibit FLT3 and downstream targets like Src (for example HSN431) are good leads for development as anti-AML agents