Thin films of perfectly polar crystallites with uniaxial orientational ordering

The family of metal-organic complexes,(4-dialkylaminopyridyl)bis(acetylacetonato)zinc(II) which show perfectly polar assembly in the crystalline state are found to grow as orientationally ordered crystallites in vapor deposited thin films on glass substrates. A unique crystallographic axis of the crystallites, the longest unit cell axis in most cases, is oriented perpendicular to the substrate plane. The fact that the current observations cover a family of compounds is novel and of general significance for oriented thin film growth on amorphous substrates. Crystal structure, thin film morphology and second harmonic generation of a representative system are presented; the crystallites in the thin films do not show azimuthal orientational ordering

Formulation and optimization of oxaliplatin immuno-nanoparticles using Box-Behnken design and cytotoxicity assessment for synergistic and receptor-mediated targeting in the treatment of colorectal cancer

Conventional chemotherapy majorly lacks clinical application attributed to its inspecificity, adverse effects and inability to penetrate into tumor cells. Hence, the aim of the study was to prepare oxaliplatin solid lipid nanoparticles (OP-SLN) by microemulsion method optimizing it by Box-Behnken design and then covalently conjugated to TRAIL (CD-253) monoclonal antibody (TR-OP-SLN) for targeting colorectal cancer cells. The optimized OP-SLN3 has shown an appreciable particle size (121 ± 1.22 nm), entrapment efficiency (78 ± 0.09%) and drug loading (32 ± 1.01%). Fluorescence study and the Bradford assay further confirmed the binding of the protein. A 1.5-fold increase in cytotoxicity of immuno-nanoparticles (4.9 μM) was observed

Internal cancellation of electric field induced second harmonic generation in solvent mixtures and solutions: an efficient protocol for the determination of molecular hyperpolarizability

Electric field induced second harmonic generation (EFISHG) is a standard technique for the experimental determination of molecular hyperpolarizability. We have developed a novel cell design for EFISHG experiments that makes use of a conventional spectrometer glass cuvette. An efficient and convenient protocol is developed for the analysis of the EFISHG data making use of the internal cancellation of second harmonic generation in solvent mixtures and solutions to determine the first hyperpolarizability value. Calibration experiments and measurements on 4-nitroaniline in DMSO and NMP are presented. The first hyperpolarizability of the zwitterionic push-pull molecule, DCNQI, is measured in DMSO and NMP

Excited state dynamics in tetra tolyl porphyrins studied using degenerate four wave mixing with incoherent light and ps pulses

We present our experimental results on the excited state dynamics in several tetra tolyl porphyrins (with different central metal-ions) studied using degenerate four wave mixing with nanosecond incoherent light (DFWM-IL) and picosecond time-resolved four wave mixing (DFWM-PS). Incoherent light studies indicate three lifetimes, which have been attributed to different excited states. The shortest component with a decay constant of < 170 fs is due to the vibrational relaxation in the higher excited singlet states Sn(T2), 3-6 ps component is due to the vibrational relaxation of the Franck-Condon states in S1(tvib), and the long component of 20-100 ps is due to the population relaxation (T1) from S1 to S0. The population relaxation times obtained from time-resolved DFWM studies using a picosecond laser substantiates these results