A longitudinal study of hepatitis B surface antibody level after the accelerated vaccination protocol applied to health workers in a hospital of Thailand

Background: Hepatitis B infection persists in Thailand, especially among health personnel. The current immunization protocol (3 doses in 6 months) is too slow to protect against infection; thus, an accelerated protocol has been in place as the accelerated protocol at a supra-tertiary hospital since 2014. Aim: To measure the anti-HBs level 1, 2, and 5 years post-accelerated vaccination of health personnel who had received the hepatitis vaccine using. Methods: A descriptive study was conducted. Electrochemiluminescence Immunoassay; ECLIA (Roche Diagnostic Cobas 6000, Indianapolis, IN) was used to measure the anti-HB level 1, 2, and 5 years after the third dose in 73, 58, and 20 participants, respectively. Findings: The starting group number declined over time as workers resigned or transferred away, so the tested number in years 2 and 5 represents the remaining workers that started the study in year 1. The respective geometric mean titer after 1, 2, and 5 years was 1765.8, 164.7, and 107.9 mIU/mL. Fifty-four participants (93.1%) had lower antibody levels in the second year than in the first year. Nine participants (45.0%) had lower antibody levels in the fifth year than in the second year. Conclusion: The anti-HBs level declined from the first to the second and fifth years; however, the anti-HBs level persisted at a protective level. The accelerated protocol benefited health personnel, protecting them from hepatitis B infection

Enterprise-Based Participatory Action Research in the Development of a Basic Occupational Health Service Model in Thailand

Various basic occupational health services (BOHS) are provided, particularly in-plant BOHS; however, it might be necessary to start expanding BOHS. The current study focuses on BOHS model development using participatory action research (PAR) at a large-sized enterprise in northeastern Thailand. The PAR began with a situation analysis using ILO Convention C161, problem and cause analysis, the development of an action plan, observation and action, evaluation, and replanning. The research tools included interviews, focus group discussions (FGDs), and participant observations. The participants included managers, human resource staff, safety officers, and workers. Both inductive and deductive thematic analyses were undertaken. The results showed that (1) education and learning experience led to the workers detecting work-related diseases early by themselves and the implementation of medical surveillance programs; (2) the workers’ occupational health needs led to return-to-work assessments and first aid room system development; (3) the employer’s experience led to appropriate fit-for-work examinations and emergency preparedness; and (4) the feedback from BOHS providers led to a hospital-to-in-plant return-to-work conversion. The study concluded that the enterprise could develop fit-for-work and return-to-work assessments as per the ILO Convention C161 under the policy; however, medical surveillance and the first aid room system need to be developed through counseling at the hospital’s occupational medicine clinic

Validation of the Brief Thai Version of the Work-Related Quality of Life Scale (Brief THWRQLS)

The Work-Related Quality of Life Scale (WRQLS) was developed by Van Laar et al. The Thai version was developed and could be completed in 13.4 min on average with some items having a factor loading of less than 0.4. The aims of this study were (a) to develop a brief Thai version of the WRQLS (brief THWRQLS), and (b) to assess its validity and reliability. A descriptive correlation study was performed with the components of THWRQLS selected based on statistical and judgmental criteria. The statistical criteria were developed using secondary data from 320 physicians identifying discrimination, internal consistency and exploratory factor analysis (EFA). The judgmental criteria included content validity and agreement by five experts. The web-based brief THWRQLS was then used by 250 health personnel, and confirmatory factor analysis (CFA) was conducted and internal consistency assessed. The brief THWRQLS consisted of seven dimensions, encompassing 25 of the original 32 items. The CFA revealed that most of the standardized factor loadings were greater than 0.5. The χ2goodness of fit was 268.772 (p < 0.01), the comparative fit index was 0.971, the root mean square error of approximation was 0.039, and the standardized root mean square residual was 0.049. The Cronbach’s alpha coefficient of the scale was 0.94, and almost all dimensions were greater than 0.7 except for that of “stress at work,” which was 0.53. In conclusion, the brief THWRQLS appeared to be valid, and the reliability was acceptable, except in the dimension of “stress at work.&rdquo

The Proportion of Occupationally Related Cholangiocarcinoma: A Tertiary Hospital Study in Northeastern Thailand

Northeastern Thailand registers the highest worldwide incidence of cholangiocarcinoma (CCA). Most of the cases are associated with liver flukes, while unknown causes comprise approximately 10–30% of cases, and these could be due to occupational exposures. Our aim was to determine the magnitude of occupational causes of CCA in a tertiary hospital in northeastern Thailand. We conducted a cross-sectional study with a sample of 220 patients between March and November 2021. Descriptive statistics were used to analyze the findings. Clinical information and telephone interviews were used to explore significant occupational histories. An occupational consensus meeting was held with two occupational physicians, an industrial hygienist, and a hepatobiliary surgeon to decide on the final diagnosis. The response rate was 90.9% (200/220). Based on the medical records and telephone interviews, researchers found that 11 participants had significant exposure. After occupational consensus, it was agreed that the eleven had possible occupational causes, 5.5% (11/200)–54.5% (6/11) being due to asbestos fibers, 45.5% (5/11) due to dichloromethane, and 9.1% (1/11) due to 1,2-dichloropropane. Only 4% (8/200) had occupational histories collected by their treating physicians. Taken together, occupationally related CCA appears to have been underestimated, so improving occupational history taking is needed to properly identify and classify work-related CCA—both for patient treatment and occupational hazard prevention

Concentrations and size distribution of inhalable and respirable dust among sugar industry workers:a pilot study in Khon Kaen, Thailand

There has been very limited information regarding bagasse exposure among workers in sugar industries as well as on health outcomes. The authors determined the occupational exposure of sugar industry workers in Khon Kaen to airborne bagasse dust. The size of the bagasse dust ranged from 0.08 to 9 µm with the highest size concentration of 2.1 to 4.7 µm. The most common size had a geometric mean diameter of 5.2 µm, with a mass concentration of 6.89 mg/m3/log µm. The highest mean values of inhalable and respirable dust were found to be 9.29 mg/m3 from February to April in bagasse storage, 5.12 mg/m3 from May to September, and 4.12 mg/m3 from October to January. Inhalable dust concentrations were 0.33, 0.47, and 0.41 mg/m3, respectively. Workers are likely to be exposed to high concentrations of bagasse dust and are at risk of respiratory diseases. Preventive measures, both in the form of engineering designs and personal protective devices, should be implemented. </jats:p

Validation of the Thai Version of a Work-related Quality of Life Scale in the Nursing Profession

Background: Currently available questionnaires for evaluating the quality of worklife do not fully examine every factor related to worklife in all cultures. A tool in Thai is therefore needed for the direct evaluation of the quality of worklife. Our aim was to translate the Work-related Quality of Life Scale-2 (WRQLS-2) into Thai, to assess the validity and reliability of the Thai-translated version, and to examine the tool's accuracy vis-à-vis nursing in Thailand. Methods: This was a descriptive correlation study. Forward and backward translations were performed to develop a Thai version of the WRQLS. Six nursing experts participated in assessing content validity and 374 registered nurses (RNs) participated in its testing. After a 2-week interval, 67 RNs were retested. Structural validity was examined using principal components analysis. The Cronbach's alpha values were calculated. The respective independent sample t test and intraclass correlation coefficient were used to analyze known-group validity and test–retest reliability. Multistate sampling was used to select 374 RNs from the In- and Outpatient Department of Srinagarind Hospital of the Khon Kaen University (Khon Kaen, Thailand). Results: The content validity index of the scale was 0.97. Principal components analysis resulted in a seven-factor model, which explains 59% of the total variance. The overall Cronbach's alpha value was 0.925, whereas the subscales ranged between 0.67 and 0.82. In the assessment results, the known-group validity was established for the difference between civil servants and university employees [F (7.982, 0.005) and t (3.351; p < 0.05)]. Civil servants apparently had a better quality worklife, compared to university employees. Good test–retest reliability was observed (r = 0.892, p < 0.05). Conclusion: The Thai version of a WRQLS appears to be well validated and practicable for determining the quality of the work-life among nurses in Thailand

Effect of Latex Purification and Accelerator Types on Rubber Allergens Prevalent in Sulphur Prevulcanized Natural Rubber Latex: Potential Application for Allergy-Free Natural Rubber Gloves

Natural rubber (NR) gloves manufactured from NR latex are widely utilized in various applications as a personal protective device due to their exceptional barrier characteristics in infection control. However, the use of NR gloves was associated with concerns on NR protein allergy. With comprehensive leaching procedures now a common practice in NR latex glove factories to eliminate latent rubber proteins and chemical allergens, occurrences and complaints of protein allergy from medical glove users have decreased drastically over the past two decades. The present work aims to eliminate further the residual rubber allergens in NR latex through effective purification of the NR latex and compounding the thus purified latex with an established formulation for allergy-free NR for glove applications. NR latex was purified by deproteinization and saponification, respectively. Several analytical techniques were used to verify rubber allergens eliminated in the purified latexes. Saponified NR (SPNR) latex was the purified NR latex of choice since it is devoid of allergenic proteins and poses the lowest risk of Type I allergy. The purified NR latex was compounded with zinc diethyldithiocarbamate (ZDEC), zinc dibutyldithiocarbamate (ZDBC), and zinc 2-mercaptobenzothiazole (ZMBT), respectively, for glove dipping. Among the investigated accelerators, only ZDBC was not detected in the artificial sweat that came into contact with the dipped articles. Thus, it is deduced that ZDBC poses the lowest risk of Type IV allergy to consumers. Additionally, the morphological and physical properties of dipped articles were assessed. It was revealed that the dipped film from the SPNR latex compounded with ZDBC provided thinner and less yellow products with a more uniform internal structure and a tensile strength comparable to those of commercial NR gloves

Preliminary Psychometric Properties of the Chinese Version of the Work-Related Quality of Life Scale-2 in the Nursing Profession

Objectives: As quality of work-life (QWL) among nurses affects both patient care and institutional standards, assessment regarding QWL for the profession is important. Work-related Quality of Life Scale (WRQOLS) is a reliable QWL assessment tool for the nursing profession. To develop a Chinese version of the WRQOLS-2 and to examine its psychometric properties as an instrument to assess QWL for the nursing profession in China. Methods: Forward and back translating procedures were used to develop the Chinese version of WRQOLS-2. Six nursing experts participated in content validity evaluation and 352 registered nurses (RNs) participated in the tests. After a two-week interval, 70 of the RNs were retested. Structural validity was examined by principal components analysis and the Cronbach's alphas calculated. The respective independent sample t-test and intra-class correlation coefficient were used to analyze known-group validity and test-retest reliability. Results: One item was rephrased for adaptation to Chinese organizational cultures. The content validity index of the scale was 0.98. Principal components analysis resulted in a seven-factor model, accounting for 62% of total variance, with Cronbach's alphas for subscales ranging from 0.71 to 0.88. Known-group validity was established in the assessment results of the participants in permanent employment vs. contract employment (t = 2.895, p < 0.01). Good test-retest reliability was observed (r = 0.88, p < 0.01). Conclusion: The translated Chinese version of the WRQOLS-2 has sufficient validity and reliability so that it can be used to evaluate the QWL among nurses in mainland China

A Lung Granuloma Case Possibly Associated with a Working Environment: A Case Report

Lung granulomas are uncommon in Thailand. The disease typically develops from an occupational environment and is mostly caused by infection. Herein is a case report of a female patient, aged 48, working as a nurse in an Accident and Emergency Department at a hospital. Eighteen years prior to admission the patient was diagnosed with myasthenia gravis and pulmonary tuberculosis. The chest X-ray and CT scans showed a solitary pulmonary nodule in the lower left lung. The patient received an open thoracotomy with a left lobectomy. Granulomatous and nonseptate hyphae were found in the pathology diagnosis. The patient was thus diagnosed as having a lung granuloma. The galactomannan antigen test was positive. The solitary pulmonary nodule—found from the use of a Polymerase Chain Reaction (PCR) test—was an Aspergillus spp. The fungus culture was collected from air samples. The air samples were collected by the impaction technique using a microbial air sampler. Three types of Aspergillus spp. were found as well as Penicillium spp. and Monilia sitophila. The Aspergillus spp. was a match for the patient's disease. The patient was diagnosed as having a lung granuloma possibly Aspergillus nodule which was caused by airborne Aspergillus spp. from the occupational environment