Safety Integrity Level of Shut-Off Valve in a Burner Management System

The safety control and command system, such as the burner manage-ment system, requires that the system must be reliable, available and safe. The reliability is based on choosing equipment, with a high level of safety and which is suitable for the safety system. The availability and security are provided, among others, by redundancy. It is presented by M-Canal out of N-Canal (MooN) architecture, the (N-M) indicates how many dangerous faults are possible, with-out the performance of the systems being impeded. An essential quantitative analysis based on the evaluation of the PFDavg is part to give high trust in the BMS. This paper will discuss how a quantitative method can be used to select the appropriate SIL according to shutdown system for Burner Management System (BMS). This system is a part of a safety solution that manages a combustion sys-tem; it allows the safe start-up operation, and the shutdown of multiple burner furnace section of a boiler, and main flame detection

Development and evaluation of a 2oo3 safety controller in FPGA using fault tree analysis and Markov models

The Safety integrity level (SIL) is a measure of the reliability and availability of a safety instrumented system. SIL determination involves qualitative and quantitative analysis based on international standards such as IEC 61508 and IEC 61511. Several techniques can be used to analyze safety instrumented systems, including reliability block diagrams, fault tree analysis, and Markov models. The aim of this paper is to design and evaluate a pressure control system for a compressed nitrogen tank using a PID controller implemented in a field programmable gate array with 2 out of 3 architecture. This architecture ensures the safety of measurements and command of the system through a voting arrangement. The availability of the system is determined by the redundancy and the one hardware failure tolerance. The quantitative analysis is performed by calculating the probability of failure on demand per hour using Markov models or a relevant probabilistic approach based on fault tree analysis. The Markov model method gives the probability of failure of the system in different states during the system life cycle. The fault tree analysis method determines the probability of failure of the system using its equivalent failure rate. Furthermore, this paper compares the SIL result obtained by each model

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ABSTRACT. Objective. Microsomal prostaglandin E 2 synthase-1 (mPGES-1) catalyzes the terminal step in the biosynthesis of PGE 2 . Early growth response factor-1 (Egr-1) is a key transcription factor in the regulation of mPGES-1, and its activity is negatively regulated by the corepressor NGF1-A-binding protein-1 (NAB1). We examined the effects of valproic acid (VA), a histone deacetylase inhibitor, on interleukin 1ß (IL-1ß)-induced mPGES-1 expression in human chondrocytes, and evaluated the roles of Egr-1 and NAB1 in these effects. Methods. Chondrocytes were stimulated with IL-1 in the absence or presence of VA, and the level of mPGES-1 protein and mRNA expression were evaluated using Western blotting and real-time reverse-transcription polymerase chain reaction (PCR), respectively. mPGES-1 promoter activity was analyzed in transient transfection experiments. Egr-1 and NAB1 recruitment to the mPGES-1 promoter was evaluated using chromatin immunoprecipitation assays. Small interfering RNA (siRNA) approaches were used to silence NAB1 expression. Results. VA dose-dependently suppressed IL-1-induced mPGES-1 protein and mRNA expression as well as its promoter activation. Treatment with VA did not alter IL-1-induced Egr-1 expression, or its recruitment to the mPGES-1 promoter, but prevented its transcriptional activity. The suppressive effect of VA requires de novo protein synthesis. VA induced the expression of NAB1, and its recruitment to the mPGES-1 promoter, suggesting that NAB1 may mediate the suppressive effect of VA

:3; Personal non-commercial use only. The Journal of Rheumatology of NAB1. (First Release

ABSTRACT. Objective. Microsomal prostaglandin E 2 synthase-1 (mPGES-1) catalyzes the terminal step in the biosynthesis of PGE 2 . Early growth response factor-1 (Egr-1) is a key transcription factor in the regulation of mPGES-1, and its activity is negatively regulated by the corepressor NGF1-A-binding protein-1 (NAB1). We examined the effects of valproic acid (VA), a histone deacetylase inhibitor, on interleukin 1ß (IL-1ß)-induced mPGES-1 expression in human chondrocytes, and evaluated the roles of Egr-1 and NAB1 in these effects. Methods. Chondrocytes were stimulated with IL-1 in the absence or presence of VA, and the level of mPGES-1 protein and mRNA expression were evaluated using Western blotting and real-time reverse-transcription polymerase chain reaction (PCR), respectively. mPGES-1 promoter activity was analyzed in transient transfection experiments. Egr-1 and NAB1 recruitment to the mPGES-1 promoter was evaluated using chromatin immunoprecipitation assays. Small interfering RNA (siRNA) approaches were used to silence NAB1 expression. Results. VA dose-dependently suppressed IL-1-induced mPGES-1 protein and mRNA expression as well as its promoter activation. Treatment with VA did not alter IL-1-induced Egr-1 expression, or its recruitment to the mPGES-1 promoter, but prevented its transcriptional activity. The suppressive effect of VA requires de novo protein synthesis. VA induced the expression of NAB1, and its recruitment to the mPGES-1 promoter, suggesting that NAB1 may mediate the suppressive effect of VA. Indeed, NAB1 silencing with siRNA blocked VA-mediated suppression of IL-1-induced mPGES-1 expression. Conclusion. VA inhibited IL-1-induced mPGES-1 expression in chondrocytes. The suppressive effect of VA was not due to reduced expression or recruitment of Egr-1 to the mPGES-1 promoter and involved upregulatio