The link between the genetic polymorphisms of the innate immune signaling molecular factors with periodontitis

Periodontitis is a chronic inflammatory disease causing destruction of supporting tissues of teeth. Even though the gramnegative anaerobes are essential for the initiation of periodontal destruction, multiple risk factors are essential for the progression of the disease. The genetic risk factor plays a significant role in the etiopathogenesis of periodontal disease. The innate immune mechanism is the first line of defense in screening and combating the invading periodontal pathogens. The genetic polymorphisms in the 3’UTR region of the innate immune signaling molecular factors like toll-like receptors, nod-like receptors and the polymorphisms in the epigenetic regulators of these factors like microRNA146a, apolipoproteinE might play an important role in the etiopathogenesis of periodontal destruction

A Case of Oral Focal Mucinosis on Hard Palate: A Lesion Derived from the Periodontal Ligament

Oral Focal Mucinosis (OFM) manifests on the gingiva as a painless mass, asymptomatic except for the presence of a fibrous mass, and is of the same colour as the surrounding mucosa. It is commonly reported on the gingiva. Histologically, it is characterised by focal myxoid degeneration of connective tissue. Its diagnosis seldom can be made clinically and predominantly relies on histopathological analysis. This case report is about a 40-year-old female who had a gradually increasing swelling on the palate in relation to upper right posterior teeth, for 4-5 months. The lesion was excised and sent for histopathological and immuno-histochemical analysis. There was presence of foci of loose mucinous connective tissue stroma interspersed within dense connective tissue stroma. The mucinous stroma showed numerous stellate and spindle-shaped fibroblasts evident between thin collagen fibres with evidence of separation of collagen fibres