Intracellular cytokine profile of T lymphocytes in patients with chronic obstructive pulmonary disease

Chronic obstructive pulmonary disease (COPD) is characterized by an excessive inflammatory response to inhaled particles, mainly tobacco smoking. T lymphocytes are important regulatory cells that secrete several cytokines and participate actively in this inflammatory response. According to the pattern of cytokines secreted, the immune response is classified as cytotoxic or type 1 [interferon (IFN)-γ-, interleukin (IL)-2-dependent] and humoral or type 2 (IL-4-, IL-5-, IL-10- and IL-13-dependent). This paper sought to compare the intracellular profile of cytokine expression determined by flow cytometry in T lymphocytes harvested from bronchoalveolar lavage (BAL) and peripheral blood in patients with COPD, smokers with normal lung function and never smokers. We found that BAL T lymphocytes from COPD patients had a higher percentage of positive stained cells for most of the cytokines analysed when compared to never smokers or smokers with normal lung function. Differences reached statistical significance for IL-4, IL-10 and IL-13, particularly in CD8(+) T cells. Furthermore, the expression of most of these cytokines was related inversely to the degree of airflow obstruction present suggesting local activation and/or selective homing of T lymphocytes to the lungs in COPD patients. These observations were not reproduced in circulating T lymphocytes. These results suggest that BAL T lymphocytes in patients with COPD produce more cytokines than in controls and tend to show a type 2 pattern of intracellular cytokine expression, particularly a Tc-2 profile. This is related inversely to the degree of airflow obstruction present

The Trap of Intellectual Success. Robert N. Bellah, the American Civil Religion Debate, and the Sociology of Knowledge

Current sociology of knowledge tends to take for granted Robert K. Merton\u2019s theory of cumulative advantage: successful ideas bring recognition to their authors, successful authors have their ideas recognized more easily than unknown ones. The paper argues that this theory should be revised via the introduction of the differential between the status of an idea and that of its creator: when an idea is more important than its creator, the latter becomes identified with the former, and this will hinder recognition of the intellectual\u2019s new ideas as they differ from old ones in their content and/or style. Robert N. Bellah\u2019s performance during the \u201ccivil religion debate\u201d of the 1970s is reconstructed as an example of how this mechanism may work. Implications for further research are considered in the conclusive section