IDENTIFICATION OF FGFR INHIBITOR AS ST2 RECEPTOR/INTERLEUKIN-1 RECEPTOR-LIKE 1 INHIBITOR IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE DUE TO EXPOSURE TO E-CIGARETTES BY NETWORK PHARMACOLOGY AND MOLECULAR DOCKING PREDICTION

Objective: This study was designed to search for candidate drugs that act on IL-33 and ST2, which was carried out using a bioinformatics approach. Methods: We first analyzed Network Electronic Cigarette Smokes Predictions of therapeutic targets by Cytoscape. We collected from the Swiss TargetPrediction database [http://www. swisstargetprediction. ch/] by inputting each compound structure of the electronic cigarette smoke in SDF format. The target protein data is then supplemented with UniProt ID data to uniform protein identity. We then identified COPD Related Targets in Humans by Cytoscape. Subsequently, we identified key receptors in the pathogenesis of COPD. All target proteins that have a significant role in the pathogenesis of COPD exposed to cigarette smoke will be known from the combination of this network. Results: Based on the validation results of the protein receptor for ST2, a protein is used as a receptor with PDB ID: 1IRA. After analyzed by PyMol software, a protein with PDB ID 1IRA it has no missing residue in its sequenceDrug candidates analyzed by the structural similarity with the native ligand using PubChem and DRUGBANK analysis are follow: N-acetylmannosamine, Aceneuramic acid, Ceramide AP, Ceramide NP, Hg9a-9, Nonanoyl-N-hydroxyethylglucamide, N-Acetyl-2-deoxy-2-amino-galactose, N-Acetyllactosamine, MLi/2,6-dimethyl-4-[6-[5-[1-methylcyclopropyl] oxy-1H-indazol-3-yl] pyrimidin-4-yl] morpholine, Terazosin, BMS-911543, NAG Inhibitor, FGFR Inhibitor/sodium; 2-amino-5-[1-methoxy-2-methylindolizine-3-carbonyl] benzoate. After docking, the smallest or more negative binding affinity values are obtained. The stronger the FGFR Inhibitor ligand showed the interaction with the Receptor with a binding affinity value of-9.0 kcal/mol with mode/position 0, and RMSD 0.0. The second smallest binding affinity value is the NAG ligand with a-8.5 kcal/mol with mode/position 0 and RMSD 0.0. Conclusion: The findings revealed that FGFR Inhibitor was a suitable repurposing medication for anti-COPD development via the IL-33/ST-2 signaling pathway

Hubungan Sosial Ekonomi dengan Tingkat Pendidikan pada Masyarakat Pesisir di Desa Pematang Lalang, Kecamatan Percut Sei Tuan: Socio-Economic Relations with Education Levels in Coastal Communities in Pematang Lalang Village, Percut Sei Tuan District

Pendidikan merupakan suatu indikator yang bisa mempengaruhi adanya pertumbuhan ekonomi yang bisa meningkatkan pendapatan di dalam masyarakat, sehingga pendidikan dapat mendorong pertumbuhan ekonomi, begitupun sebaliknya pertumbuhan ekonomi dapat memperlancar pendidikan di dalam suatu daerah maupun perdesaan. Jenis penelitian ini adalah penelitian kuantitatif karena hasil penelitian ini di dapatkan dari narasumber dengan melakukan tanya jawab. Adapun desain penelitian yang ditemukan dengan mengumpulkan data yang ada kaitannya dengan variabel yang akan diteliti melalui wawancara,observasi dan dokumentasi. Populasi dalam penelitian ini adalah warga pesisir di Daerah Pematang Lalang. Sampel merupakan bagian dari populasi yang mempunyai kualitas yang dapat mewakili keseluruhan populasi. Proses pengambilan sampel dilakukan secara tidak acak (nonprobability sampling) dengan teknik purposive sampling, yaitu cara pengambilan sampel berdasarkan kriteria tertentu. Kriteria yang dimaksud dalam penelitian ini adalah warga setempat yang bekerja nelayan sebanyak 30 responden