22 research outputs found
Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases
- Author
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- The Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group
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- Publication venue
- Publication date
- 09/08/2008
- Field of study
The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular "reactive oxygen species" (ROSs)
can exhibit a number of biological effects, they are not of themselves
excessively reactive and thus they are not especially damaging at physiological
concentrations. However, their reactions with poorly liganded iron species can
lead to the catalytic production of the very reactive and dangerous hydroxyl
radical, which is exceptionally damaging, and a major cause of chronic
inflammation. We review the considerable and wide-ranging evidence for the
involvement of this combination of (su)peroxide and poorly liganded iron in a
large number of physiological and indeed pathological processes and
inflammatory disorders, especially those involving the progressive degradation
of cellular and organismal performance. These diseases share a great many
similarities and thus might be considered to have a common cause (i.e.
iron-catalysed free radical and especially hydroxyl radical generation). The
studies reviewed include those focused on a series of cardiovascular, metabolic
and neurological diseases, where iron can be found at the sites of plaques and
lesions, as well as studies showing the significance of iron to aging and
longevity. The effective chelation of iron by natural or synthetic ligands is
thus of major physiological (and potentially therapeutic) importance. As
systems properties, we need to recognise that physiological observables have
multiple molecular causes, and studying them in isolation leads to inconsistent
patterns of apparent causality when it is the simultaneous combination of
multiple factors that is responsible. This explains, for instance, the
decidedly mixed effects of antioxidants that have been observed, etc...Comment: 159 pages, including 9 Figs and 2184 reference
Elimination of Truncal Vein Reflux: Surgery, Thermal Ablation, and Chemical Ablation for Chronic Venous Disorders
- Author
- A Caggiati
- A Cavezzi
- A Hamahata
- A Hingorani
- A Oesch
- A Puggioni
- A Puggioni
- A Riij van
- A Rij van
- AC Shepard
- AI Mekako
- B Campbell
- B Disselhoff
- B Egan
- B Knipp
- BC Disselhoff
- C Franceschi
- C Hamel-Desnos
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- G Mozes
- GA Spitz
- I Ahmad
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- LS Kabnick
- M Cappelli
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- MP Goldman
- N Khilnai
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- NS Sadick
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- P Conrad
- P Gloviczki
- P Pittaluga
- P Pittaluga
- P Pittuluga
- P Timperman
- P Zamboni
- PE Timperman
- PFS Chong
- PH Rutgers
- R Bos Van den
- R Bos van den
- R Ceulen
- R Weiss
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- RA Neser
- RF Merchant
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- RJ Min
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- S Carandino
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- S Zimporin
- SD Goode
- T Lees
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- T Proebstle
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- TM Proebstle
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- V Bremer den
- V Scavee
- W Marston
- W Marston
- W Stuart
- X Kurz
- Y Tong
- Publication venue
- 'Springer Science and Business Media LLC'
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Polidocanol versus hypertonic glucose for sclerotherapy treatment of reticular veins of the lower limbs: study protocol for a randomized controlled trial
- Author
- Andrei Moroz
- B Eklof
- Carlos Eduardo Pinheiro LĂșcio Filho
- DM Duffy
- E Rabe
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- H Partsch
- Hamilton Almeida Rollo
- J Zhang
- Jamil Victor de Oliveira MariĂșba
- JD Peterson
- JJ Bergan
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- Matheus Bertanha
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- Rafael Elias Farres Pimenta
- Regina Moura
- Rodrigo Gibin Jaldin
- RP Ceulen
- S Kobayashi
- S McCoy
- T Willenberg
- Winston Bonetti Yoshida
- Publication venue
- 'Springer Science and Business Media LLC'
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- Field of study
P-V matrix and enumeration of Kekulïżœ structures
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- A Graovac
- AT Balaban
- AT Balaban
- AT Balaban
- BN Cyvin
- D Babi?
- D Cvetkovi?
- D Cvetkovi?
- DJ Klein
- DJ Klein
- H Sachs
- He Wenchen
- He Wenchen
- He Wenjie
- I Gutman
- I Gutman
- I Gutman
- I Gutman
- I Gutman
- JL Bergan
- M Gordon
- M Randi?
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- MJS Dewar
- N Ohkami
- NS Ham
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- P John
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- P K?ivka
- PC Hilberty
- S El-Basil
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- SJ Cyvin
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- SJ Cyvin
- SJ Cyvin
- SJ Cyvin
- SJ Cyvin
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- SJ Cyvin
- SJ Cyvin
- SJ Cyvin
- SJ Cyvin
- W GrĂŒndler
- WC Herndon
- WC Herndon
- Y-S. Jiang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1989
- Field of study
An infectious disease and pharmacokinetic perspective on oral antibiotic treatment of uncomplicated urinary tract infections due to multidrug-resistant Gram-negative uropathogens: the importance of urinary antibiotic concentrations and urinary pH
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- A Burian
- B. A. Cunha
- BA Cunha
- BA Cunha
- BA Cunha
- BA Cunha
- BA Cunha
- BA Cunha
- BA Cunha
- BA Cunha
- BA Cunha
- BA Cunha
- BA Cunha
- BA Cunha
- D Greenwood
- DM Musher
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- GV Doern
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- J Garau
- JA Washington 2nd
- JB Comer
- KB Klein Breteler
- L Yang
- MR Jacobs
- MW Woodruff
- N Frimodt-MĂžller
- NS Hamid
- P Komp Lindgren
- PA Ristuccia
- S Begic
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- SE Trevino
- SS Patel
- T Bergan
- TA Stamey
- TA Stamey
- TA Stamey
- V Lorian
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Oligodeoxynucleotides Enhance Lipopolysaccharide-Stimulated Synthesis of Tumor Necrosis Factor: Dependence on Phosphorothioate Modification and Reversal by Heparin
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- A BĂžyum
- AM Gewirtz
- AM Krieg
- Anne Krug
- B Jansen
- C Chavany
- CA Stein
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- D Pennica
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- G Schwab
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- GL Nichols
- Gunther Hartmann
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- S Endres
- S Haskill
- SG Obrien
- Stefan Endres
- T Gura
- T Skorski
- WB Offensperger
- WM Galbraith
- Publication venue
- 'Springer Science and Business Media LLC'
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- Field of study
TragfÀhigkeit von Platten und Schalen aus bewehrtem Beton mit geometrischen und physikalischen nichtlinearen Effekten
- Author
- A Arnesen
- ACI Standard
- ACT Chen
- ASCE Committee on concrete and masonry structures Task Committee on Finite Element Analysis of Reinforced Concrete Structures
- CS Lin
- CS Lin
- DRJ Owen
- DRJ Owen
- E Andenaes
- E Hinton
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- F Damjanic
- FR Hand
- FR Hand
- G Mueller
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- H Duddeck
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- H Kupfer
- HA Mang
- HB Kupfer
- HHA Rahman
- J Wastiels
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- JC Jofriet
- JH Argyris
- KH Gerstle
- KH Gerstle
- KH Gerstle
- KJ Bathe
- L Cedolin
- L Cedolin
- LL Mills
- MA Hogge
- MN Fardis
- NS Ottosen
- O Buyukozturk
- OC Zienkiewicz
- PG Bergan
- PG Hodge
- RC Fenwick
- RI Gilbert
- RJ Cope
- S Ahmad
- TCY Liu
- TJR Hughes
- WC Schnobrich
- WF Chen
- YD Hamadi
- ZP Bazant
- ZP Bazant
- ZP Bazant
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1990
- Field of study
Posterior amygdala regulates sexual and aggressive behaviors in male mice
- Author
- A Dobin
- A Mathis
- AL Falkner
- AS Lewis
- Byungkook Lim
- C Dulac
- CF Yang
- CW Malsbury
- D Knowland
- D Lin
- Dayu Lin
- DE Emery
- Dongyu Wei
- DW Bayless
- EK Unger
- F Wang
- G Cui
- GD Petrovich
- GM Alexander
- GW Arendash
- H Lee
- HW Dong
- J Brody
- JF Bergan
- JM Dominguez
- JS Klaric
- K Hashikawa
- KS Ervin
- L Cimmino
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- L Wang
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- LA Gunaydin
- LA Schwarz
- LM Coolen
- LM Coolen
- LW Swanson
- M Hatayama
- ME Ritchie
- MN Lehman
- Nicolas X. Tritsch
- NS Canteras
- NS Canteras
- NW Hoffman
- RB Simerly
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- S Kollack-Walker
- S Stagkourakis
- SM Miller
- Soomin C. Song
- SX Ge
- T Shimura
- T Yamaguchi
- Takashi Yamaguchi
- W Hong
- X Zha
- Y Kim
- Y Li
- Y Liao
- YC Liu
- YC Wei
- YY Fang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
A Review on Membrane Finite Elements with Drilling Degree of Freedom
- Author
- A Boujelben
- A Cazzani
- A de Klerk
- A Ibrahimbegovic
- A Ibrahimbegovic
- A Ibrahimbegovic
- A Ibrahimbegovic
- A Ibrahimbegovic
- A Ibrahimbegovic
- A Ibrahimbegovic
- A Kefal
- A Madeo
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- A-P Wang
- AA Cannarozzi
- AA Groenwold
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- AB Sabir
- BF de-Veubeke
- C Bucher
- C Chinosi
- C Choi
- C Rebiai
- C Rebiai
- C Rebiai
- C Xing
- CA Felippa
- CA Felippa
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- CK Choi
- CK Choi
- CK Choi
- CK Choi
- CM Shin
- CS Long
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- DJ Allman
- DJ Allman
- DJ Allman
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- E Reissner
- EL Wilson
- EL Wilson
- F Kikuchi
- F Rojasa
- G Pimpinelli
- G Prathap
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- GA Mohr
- H Kebari
- H Matsubara
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- H Nguyen-Van
- H Zhang
- IA MacLeod
- J Eom
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- J Robinson
- JC Simo
- JC Simo
- JC Simo
- JL Tocher
- JT Yeh
- K Alvin
- K Daszkiewicz
- K Meftah
- K Meftah
- K Wisniewski
- K Wisniewski
- KC Park
- KD Kim
- KH Guerraiche
- KJ Bathe
- KY Sze
- KY Sze
- KY Sze
- KY Sze
- KY Sze
- KY Sze
- L Leonetti
- LM Tang
- M Iura
- M Rezaiee-Pajand
- M Rezaiee-Pajand
- M Rezaiee-Pajand
- M Rezaiee-Pajand
- M Rezaiee-Pajand
- MA Aminpour
- MA Aminpour
- MJ Turner
- MT Belarbi
- MT Belarbi
- N Carpenter
- N Choi
- N Stander
- NA Nodargi
- NA Nodargi
- NS Lee
- OC Zienkiewicz
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- PG Bergan
- PG Bergan
- PG Bergan
- PG Bergan
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- R Courant
- R Dungar
- R Piltner
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- RAS Moreira
- RD Cook
- RD Cook
- RD Cook
- RD Cook
- RD Cook
- RD Cook
- RD Cook
- RH MacNeal
- RH MacNeal
- RH MacNeal
- RH MacNeal
- RL Taylor
- RW Clough
- S Cen
- S Geyer
- S Kugler
- SL Sun
- SM Yunus
- SM Yunus
- SM Yunus
- THH Pian
- TJR Hughes
- TJR Hughes
- TL Chang
- TP Pawlak
- TY Lee
- W Chen
- W Chen
- W Zouari
- W Zouari
- WX Zhong
- X Gao
- XM Chen
- Y Kanda
- Y Shang
- Y Shang
- Y Shang
- Y Zhu
- YQ Long
- YQ Long
- YQ Long
- YQ Long
- YS Choo
- ZF Long
- Publication venue
- 'Springer Science and Business Media LLC'
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- Field of study
Afferent projections to the different medial amygdala subdivisions: a retrograde tracing study in the mouse
- Author
- A Bader
- A Guillamon
- A Mohedano-Moriano
- A Petrulis
- A Pitkanen
- AJ McDonald
- AJ McDonald
- AL Falkner
- B Cadiz-Moretti
- BD Rood
- Bernardita CĂĄdiz-Moretti
- BH Turner
- C Pardo-Bellver
- C Rosa-Prieto de la
- C Shi
- CE Fulwiler
- CJ Shi
- CL Samuelsen
- CL Samuelsen
- D Lin
- D Sierra-Mercado
- DJ Calu
- DM Gomez
- E Lanuza
- E Lanuza
- EK Polston
- Enrique Lanuza
- F Bordi
- F MartĂnez-GarcĂa
- F Nodari
- F Papes
- F Scalia
- F Zufall
- FE Olucha-Bordonau
- Fernando MartĂnez-GarcĂa
- G Cousens
- G Gu
- G Oxley
- G Paxinos
- GA Cousens
- GB Choi
- GD Petrovich
- H Arakawa
- H Campenhausen von
- HA Halem
- HD Morgan
- HW Dong
- HW Dong
- I Salazar
- J Krieger
- J Moncho-Bogani
- J Swann
- JA Morris
- JA Thompson
- JB Rosen
- JE LeDoux
- JE LeDoux
- JE LeDoux
- JF Bergan
- JG Pfaus
- JG Pfaus
- JG Veening
- JG Veening
- JG Veening
- JL Goodson
- JM Koolhaas
- JS Olmos de
- K Majak
- K Sano
- KG Kjelstrup
- KG Usunoff
- KK Gulia
- KM Hurley
- KS Tachikawa
- L Bourgeais
- L Cahill
- L Fortes-Marco
- L Nitecka
- L Puelles
- LA Cenquizca
- LB Haberly
- LK Takahashi
- LK Takahashi
- LM Coolen
- LW Swanson
- LW Swanson
- M Bupesh
- M Halpern
- M Meredith
- M Meredith
- M Otero-Garcia
- M Yokosuka
- MA Pezzone
- Marcos Otero-GarcĂa
- MJ Tetel
- MK Christensen
- MN Lehman
- MS Erskine
- MS Krieger
- N Gutiérrez-Castellanos
- N Gutiérrez-Castellanos
- N Kang
- N Kang
- N Palomero-Gallagher
- NN Doron
- NS Canteras
- NS Canteras
- NS Canteras
- NS Canteras
- NS Canteras
- OP Ottersen
- OP Ottersen
- P Chamero
- P Pro-Sistiaga
- PM Maras
- PM Maras
- PM Maras
- PY Risold
- PY Risold
- R Linke
- R Tirindelli
- RA Dielenberg
- RB Simerly
- RB Simerly
- RH Thompson
- RP Vertes
- RP Vertes
- S Kollack-Walker
- S Li
- S Maren
- S Riviere
- S Tsukahara
- SA Hari Dass
- SC Motta
- SW Mitra
- SW Newman
- T Kishi
- T Leinders-Zufall
- V Bautze
- V Bautze
- WN Zhang
- Y Isogai
- Y Wang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study