7 research outputs found
The Methods to Improve Quality of Service by Accounting Secure Parameters
A solution to the problem of ensuring quality of service, providing a greater
number of services with higher efficiency taking into account network security
is proposed. In this paper, experiments were conducted to analyze the effect of
self-similarity and attacks on the quality of service parameters. Method of
buffering and control of channel capacity and calculating of routing cost
method in the network, which take into account the parameters of traffic
multifractality and the probability of detecting attacks in telecommunications
networks were proposed. The both proposed methods accounting the given
restrictions on the delay time and the number of lost packets for every type
quality of service traffic. During simulation the parameters of transmitted
traffic (self-similarity, intensity) and the parameters of network (current
channel load, node buffer size) were changed and the maximum allowable load of
network was determined. The results of analysis show that occurrence of
overload when transmitting traffic over a switched channel associated with
multifractal traffic characteristics and presence of attack. It was shown that
proposed methods can reduce the lost data and improve the efficiency of network
resources.Comment: 10 pages, 1 figure, 1 equation, 1 table. arXiv admin note: text
overlap with arXiv:1904.0520
Employment of gene expression profiling to identify transcriptional regulators of hepatic stellate cells
Activated hepatic stellate cells (HSC) play a central role in scar formation that leads to liver fibrosis. The molecular mechanisms underlying this process are not fully understood. Microarray and bioinformatics analyses have proven to be useful in identifying transcription factors that regulate cellular processes such as cell differentiation. Using oligonucleotide microarrays, we performed transcriptional analyses of activated human HSC cultured on Matrigel-coated tissue culture dishes. Examination of microarray data following Matrigel-induced deactivation of HSC revealed a significant down-regulation of myocardin, an important transcriptional regulator in smooth and cardiac muscle development. Thus, gene expression profiling as well as functional assays of activated HSC have provided the first evidence of the involvement of myocardin in HSC activation