8 research outputs found
Modulation of the Gaba- and Pentobarbital-Gated Cl Current by Intracellular Calcium in Frog Sensory Neurons
The level of DNA damage in mouse hematopoietic cells and in frog and human blood cells, as induced by the action of reactive oxygen species in vitro
MPP+ selectively affects calcium homeostasis in mesencephalic cell cultures from embryonal C57/B16 mice
Pancreatic and snake venom presynaptically active phospholipases A2 inhibit nicotinic acetylcholine receptors
Inhibition of Nicotinic Acetylcholine Receptors, a Novel Facet in the Pleiotropic Activities of Snake Venom Phospholipases A2
Na<sup>+</sup>/K<sup>+</sup>-pump and neurotransmitter membrane receptors
Na+/K+-pump is an electrogenic transmembrane ATPase located in the outer plasma membrane of cells. The Na+/K+-ATPase pumps 3 sodium ions out of cells while pumping 2 potassium ions into cells. Both cations move against their concentration gradients. This enzyme’s electrogenic nature means that it has a chronic role in stabilizing the resting membrane potential of the cell, in regulating the cell volume and in the signal transduction of the cell. This review will mainly consider the role of the Na+/K+-pump in neurons, with an emphasis on its role in modulating neurotransmitter receptor. Most of the literature on the modulation of neurotransmitter receptors refers to the situation in the mammalian nervous system, but the position is likely to be similar in most, if not all, invertebrate nervous systems.</p