4 research outputs found
Risk of hospitalization and death due to bone fractures after breast cancer: a registry-based cohort study
BACKGROUND: Bone fractures may have an impact on prognosis of breast cancer. The
long-term risks of bone fracture in breast cancer patients have not been
thoroughly studied. METHODS: Poisson regression was used to investigate the
incidence of hospitalisation due to bone fracture comparing women with and
without breast cancer based on Swedish National registers. Cox regression was
used to investigate the risk of being hospitalised with bone fracture, and
subsequent risk of death, in a regional cohort of breast cancer patients.
RESULTS: For breast cancer patients, the 5-year risk of bone fracture
hospitalisation was 4.8% and the 30-day risk of death following a bone fracture
hospitalisation was 2.0%. Compared with the general population, breast cancer
patients had incidence rate ratios of 1.25 (95% CI: 1.23-1.28) and 1.18 (95% CI:
1.14-1.22) for hospitalisation due to any bone fracture and hip fracture,
respectively. These ratios remained significantly increased for 10 years.
Comorbidities (Charlson Comorbidity Index 1) were associated with the risk of
being hospitalised with bone fracture. Women taking aromatase inhibitors were at
an increased risk as compared with women taking tamoxifen (HR=1.48; 95% CI:
0.98-2.22). Breast cancer patients hospitalised for a bone fracture showed a
higher risk of death (HR=1.83; 95% CI: 1.50-2.22) compared with those without
bone fracture. CONCLUSIONS: Women with a previous breast cancer diagnosis are at
an increased risk of hospitalisation due to a bone fracture, particularly if they
have other comorbidities.Swedish Research CouncilSwedish Cancer SocietyFORTEAccepte