Face recognition using wavelet transform and non-negative matrix factorization

This paper demonstrates a novel subspace projection technique via Non-Negative Matrix Factorization (NMF) to represent human facial image in low frequency subband, which is able to realize through the wavelet transform. Wavelet transform (WT), is used to reduce the noise and produce a representation in the low frequency domain, and hence making the facial images insensitive to facial expression and small occlusion. After wavelet decomposition, NMF is performed to produce region or part-based representations of the images. Non-negativity is a useful constraint to generate expressiveness in the reconstruction of faces. The simulation results on Essex and ORL database show that the hybrid of NMF and the best wavelet filter will yield better verification rate and shorter training time. The optimum results of 98.5% and 95.5% are obtained from Essex and ORL Database, respectively. These results are compared with our baseline method, Principal Component Analysis (PCA)

Bio-discretization: Biometrics authentication featuring face data and tokenised random number

With the wonders of the Internet and the promises of the worldwide information infrastructure, a highly secure authentication system is desirable. Biometric has been deployed in this purpose as it is a unique identifier. However, it also suffers from inherent limitations and specific security threats such as biometric fabrication. To alleviate the liabilities of the biometric, a combination of token and biometric for user authentication and verification is introduced. All user data is kept in the token and human can get rid of the task of remembering passwords. The proposed framework is named as Bio-Discretization. Bio-Discretization is performed on the face image features, which is generated from Non-Negative Matrix Factorization (NMF) in the wavelet domain to produce a set of unique compact bitstring by iterated inner product between a set of pseudo random numbers and face images. Bio-Discretization possesses high data capture offset tolerance, with highly correlated bitstring for intraclass data. This approach is highly desirable in a secure environment and it outperforms the classic authentication scheme

Application of Quantitative Pharmacology in Development of Therapeutic Monoclonal Antibodies

The advancement of therapeutic monoclonal antibodies during various stages of the drug development process can be effectively streamlined when appropriate translational strategies are applied. Design of successful translational strategies for development of monoclonal antibodies should allow for understanding of the dose– and concentration–response relationships with respect to both beneficial and toxic effects from early phases of drug development. Evaluation of relevant biomarkers during early stages of drug development should facilitate the successful design of safe and effective dosing strategies. Moreover, application of quantitative pharmacology is critical for translation of exposure–response relationships early on